1.The relation between polymorphisms of apliporprotein B gene and myocardial infarction.
ZANGBIN ; Haining LI ; Jinjin GUO ; Keguang WU ;
Chinese Journal of Practical Internal Medicine 2000;0(12):-
Objective To study the relationship between the apolipoprotein B(apo B) gene polymorphism and mycoardial infarction.Methods Two polymorphic sites of the apo B gene,Xba1 and Msp1 were examined by PCR in a sample of 65 patients with myocardial infarction(MI) and 60 healthy individuals selected from a population of the chinese Han nationality.Results The frequency of X+allele(presence of Xba1 cutting site)in MI cases was significantly higher than that in controls(P
2.New possible silver lining for pancreatic cancer therapy: Hydrogen sulfide and its donors.
Xu HU ; Yan XIAO ; Jianan SUN ; Bao JI ; Shanshan LUO ; Bo WU ; Chao ZHENG ; Peng WANG ; Fanxing XU ; Keguang CHENG ; Huiming HUA ; Dahong LI
Acta Pharmaceutica Sinica B 2021;11(5):1148-1157
As one of the most lethal diseases, pancreatic cancer shows a dismal overall prognosis and high resistance to most treatment modalities. Furthermore, pancreatic cancer escapes early detection during the curable period because early symptoms rarely emerge and specific markers for this disease have not been found. Although combinations of new drugs, multimodal therapies, and adjuvants prolong survival, most patients still relapse after surgery and eventually die. Consequently, the search for more effective treatments for pancreatic cancer is highly relevant and justified. As a newly re-discovered mediator of gasotransmission, hydrogen sulfide (H