To evaluate the relationship between the family atopic history(FAH) and clinical,labo- ratory parameters and diagnosis in patients with atopic dermatitis(AD).One hundred and fifty-eight AD patients were included in this study and the patients were divided into two groups,89 eases (56.3%) with FAH and 69 cases(43.7%) without FAH.The personal and family atopie history,the distribution and morphology of the lesions,five associated clinical manifestations and laboratory tests were per- formed in 158 cases with AD.In comparison of the patients with FAH with the cases without FAH,the age of onset in AD patients under two years was 92.1% and 84.1%,respectively;persistent course, 55.1% and 43.5%;the average time of intermittent course,5.7 years and 9.6 years;the age of onset of respiratory tract allergy(AR),4.1 years and 6.2 years in cases with asthma,8.8 years and 11.1 years in allergic rhinitis (R).The morbidity of asthma in patients with personal and family atopic history was higher and it was higher in Ⅰ and Ⅱ generation also.The levels of serum IgE in AD patients with per- sonal and family history of AR were higher than those in without AR history(P

Objective To assess the clinical features and associated factors of interstitial lung disease (ILD) in patients with dermatomyositis (DM).Methods Clinical data were retrospectively analyzed on 206 patients with DM collected at the Department of Dermatology,Huashan Hospital,Fudan University in the past 6 years.Chi-square test and t test were performed for statistical analysis.Results The prevalence of ILD was 49.03％ in the 206 patients with DM.Heliotrope rash on the upper eyelids,Gottron's sign (papules),arthralgia,and cough were correlated with the incidence of ILD in DM patients (all P ＜ 0.05),and of these factors,the prevalence of artharalgia and cough were positively correlated with the incidence of ILD,while the presence of Gottron's papules was negatively correlated.The patients with DM and ILD showed a higher prevalence of abnormal serum levels of lactate dehydrogenase (LDH),hydroxybutyrate dehydrogenase (HBDH) and anti-Jo-1 antibodies,as well as with a poorer pulmonary function,compared with those suffering from DM only (all P ＜0.05).Characteristic imaging findings on computed tomography (CT) scan in patients with DM and ILD included linear opacity (57.4％),high-density patchy opacity (31.7％),reticular opacity (16.8％) and even ground glass-like opacity (13.8％),usually at the bottom or apex of the lungs.Conclusions In patients with DM,the prevalence of artharalgia and cough is positively correlated,whereas the presence of Gottron's papules is negatively correlated,with the incidence of ILD.Characteristic imaging findings on CT scan in patients with DM and ILD are linear opacity,high-density patchy opacity,reticular opacity and ground glass-like opacity at the bottom and apex of lungs.