With the reform and development of higher education in China,cultural quality education in universities has obtained great achievement through practice of more than ten years.In 21st century,universities' cultural quality education is faced with new situation and tasks.Based on the existing experience,the universities should enhance understanding of cultural quality education,strengthen theoretic research and improve the whole quality of teachers,which can promote the popularization and sustainable development of cultural quality education.

China ; Humans ; Poisoning ; prevention & control ; Public Health ; Public Health Administration ; World Health Organization ; Wounds and Injuries ; prevention & control

The Sprouty protein can inhibit cel proliferation and induce apoptosis by specific interventions in the signaling pathways of tumor cells, such as receptor tyrosine kinase signaling pathway. The Sprouty protein, which is often associated with abnormal cell proliferation and transformation, is down-regulated in many tumors, stimulating the initiation and progression of tumors. The Sprouty protein exhibits potential for developing effective treatment against cancer. This paper reviews research progress on Sprouty protein in tumor.

ObjectiveTo compare the difference effects on the proximal stomach in rapid(intake rate 100 mL/min) and slow(intake rate 15 mL/min) LNLT.Methods Forty healthy subjects received both the rapid and slow LNLTs.The caloric density of the nutrient was 1 kcal/mL. The TVDRI and MVDRI were recorded,and the corresponding TVPS and MVPS were measured by B-ultrasound.Results(1) There were positive correlation was identified between TVDRI and TVPS,and between MVDRI and MVPS in both slow and rapid LNLTs.(2) TVDRI and MVPS in slow LNLT were significantly smaller than those in rapid LNLT,but MVDRI was significantly larger in slow LNLT than that in rapid LNLT.(3) TVDRI was much closer to TVPS in slow LNLT than those in rapid LNLT.But MVDRI was much closer to MVPS in rapid LNLT than those in slow LNLT.Conclusion Both slow and rapid LNLTs could be used to evaluate the accommodation to a meal and visceral sensitivity of the proximal stomach.The visceral sensitivity is related to the accommodation function.TVDRI of slow LNLT is more sensitive in estimating the visceral sensitivity of the proximal stomach;MVDRI of rapid LNLT is more accurate in estimating the accommodation of the proximal stomach.

Cancer stem cell hypothesis has become a new theory. According to this theory, cancer stem cells play a decisive role in car-cinogenesis, progression, and metastasis. This theory offered new ideas and strategies for cancer treatment. However, only a small fraction of cells in a tumor were cancer stem cells. Therefore, the identification and enrichment of these cells are significant challenges for numerous researchers conducting further study. Micro-sphere culture has been an effective tumor stem cell enrichment technolo-gy in recent years. The application of this technique makes the cancer stem cell research process easy. In addition, it makes the evalua-tion of tumor progression and prognosis of patients in clinical possible. This article will focus on the applications of this technology, and microsystem integration will be described in detail.

The concept of golden mean (Zhong Yong), i.e. moderation, is the highest principle of moral cultivation in Confucianism. It entails an exclusive methodology in addressing politics, philosophy and everything in the universe. This concept has permeated into all aspects of traditional Chinese culture. As an ancient therapy, tuina is an important part of Chinese medicine and has its characteristic theory and methods. Just like Chinese medicine, tuina has long been greatly influenced by the concept of golden mean. To better promote the development of tuina, it’s necessary to investigate the historical evolution of tuina and the concept of golden mean as well as the influence of ‘golden mean’ idea on tuina manipulation, mechanism and treatment.

Objective To investigate whether dobutamine could induce or worsen electromechanical activity synchronism in the patients with idiopathic dilated cardiomyopathy(DCM). Methods Eighteen patients with DCM[mean age ( 45.8 ? 13.9 ) years, NYHA class Ⅱ-Ⅲ, left ventricular ejection fraction(LVEF)

Sunitinib malate (SU11248 ,Sutent) is an orally available small-molecule multitargeted tyrosine kinase inhibitor that has potent anti-angiogenic and antitumour activities.In 2006 sunitinib was approved by FDA for imatinib intolerant gastrointestinal stromal tumors (GIST) patients or imatinib resistant GIST patients.This article review the molecular-based mechanism,the mechanism of resistance,the biomarker,the clinical trials and the adverse effects of sunitinib in the treatment of imatinib-resistant GIST.

Objective To explore the correlation between prethrombotic state (PTS)and chronic atrial fibrillation in elderly patients,and to analyze the risk factors.Methods A total of 142 elderly patients with chronic atrial fibrillation from May 2009 to May 2011 were selected.Patients were divided into the PTS group (n =90) and no-PTS group (n =52) by transesophageal echocardiography (TEE).The left atrial diameter (LAD),left ventricular ejection fraction (LVEF),levels of high-sensitivity c reactive protein (hs-CRP),D-Dimer (D-D),β-platelet globulin (β-TG),B type brain natriuretic peptide (BNP),P-select element (PS),endothelial damage/dysfunction mark (vWF) and platelet aggregation rate-AA (PAR-AA)were determined.The related factors of prethrombotic state in elderly patients with chronic atrial fibrillation were analyzed by the multiple regression analysis.Results There were significant differences in the time of atrial fibrillation,frequency of patients with mitral regurgitation,levels of hs-CRP,D-D,β-TG,BNP,PS,vWF and PAR-AA between the PTS group and the non-PTS group [(6.9±1.8)years vs.(4.7±1.3)years,39 cases (43.3％)vs.11 cases (21.2％),(7.8±1.0)mg/L vs.(2.7±0.4)mg/L,(706.6±38.1)μg/L vs.(270.4±28.5)μg/L,(147.2± 21.3) μg/L vs.(117.7±17.1)μg/L,(1075.4±31.2)ng/L vs.(222.6±26.0)ng/L,(88.5±13.9)μg/Lvs.(37.4±11.2)μg/L,(36.1±11.2) ×10-3U/L vs.(26.4±9.9)×10-3U/L,(27.4±12.6)％ vs.(19.7±5.7)％,t=4.52,11.18,15.31,31.20,4.89,166.46,22.59,14.06,5.45,respectively,all P＜0.01].Multivariate logistic regression analysis showed that the time of chronic atrial fibrillation,mitral regurgitation,levels of hs CRP,PS,vWF and PAR-AA were independent risk factors for PTS in elderly patients with atrial fibrillation (OR=3.57,2.19,2.91,3.28,2.37,1.98,respectively,all P＜0.05).Conclusions The time of atrial fibrillation,mitral regurgitation,levels of hsCRP,PS,vWf and PAR-AA are independent risk factors for PTS in elderly patients with chronic atrial fibrillation.