The changes of serum amino acid metabolism of rat following partial (69%) hepatectomy were investigated by measuring twenty amino acids in sera from blood collected from hepatic vein, portal vein, inferior vena cava and abdominal aorta 72 hours following surgical intervention. The results were as follows:1. The total concentrations of amino acids in sera obtained from above mentioned blood vessels were significantly elevated, especially in that from portal vein.2. The total amount of amino acid released from splanchnic organs accunted for 87% of the total amount of amino acid uptaken by regenerating liver. Both total amounts were significantly increased.3. The enhanccd essential amino acid uptaken by regenerating liver resulted in significant decrease of molar ratio of essential to nonessential amino acids in aortic serum.4. The molar ratio of the branched chain amino acids, valine, leucine and isoleucine, to the aromatic amino acids, phenylalanine and tyrosine in aortic serum was significantly declined, this was due to increased release of tyrosine by splanchnic organs and decreased uptake of this amino acid by regenerating liver.5. The uptake of branched chain amino acids by peripheral tissues was significantly inhibited and their uptake by regenerating liver was significantly increased. Thus, the regenerating liver was well supplied with branched chain amino acids.6. The release of alanine by splanchnic organs was significantly increased and its uptake by liver was simultaneously increased. Therefore, abundant raw matererial was supplied for glyconeogenesis to meet the energy need for rapidly proliferating hepatocytes.

Objective To investigate the effect of levothyrocine-thyroxine 4 (L-T4) replacement therapy on cognitive status in elderly patients with subclinical hypothyroidism (SCH).Methods One hundred and twenty elderly patients with SCH were selected and treated with thyroid hormone replacement therapy for 6 months.The thyroid functions and cognitive impairments were tested for all the subjects before and after the therapy.Results After 6 months of thyroid hormone replacement therapy,the level of thyrotropic hormone was significantly lower than that of before herapy((15.21 ± 1.78) mU/L vs.(3.46 ± 0.37) mU/L,t =6.417,P =0.0083));The neuropsyehological test performance in patients with hypothyroidism showed statistically significant improvements in clock drawing test,iconic memory,block design,complex graphics recall and delayed recall,trail making A,word list learningl,recall and recognize,forward and backward digital span,verbal fluency,and digital symbol from WAIS-RC ((8.74 ± 1.08) vs.(9.63 ± 1.32),(6.14 ± 1.03) vs.(8.47 ± 1.38),(30.36 ± 7.27) vs.(36.42 ±8.54),(13.71 ± 1.05) vs.(14.87 ± 1.38),(11.21 ± 1.13) vs.(13.56 ±1.34),(11.36 ± 1.27)vs.(13.06 ±1.47),(5.27 ±0.84) vs.(6.54 ±1.03),(63.13 ±12.09)vs.(54.63 ±10.07),(3.64 ± 1.07)vs.(4.91 ±1.32),(5.27 ±0.84) vs.(6.54±1.03),(8.52±1.16) vs.(9.83 ±0.96),(8.01 ± 0.83) vs.(8.94 ± 1.08),(4.04 ±0.57)vs.(5.37 ±0.75),(11.21 ± 1.03) vs.(13.43 ± 1.23),(33.46 ± 8.72) vs.(38.06 ± 9.58),t =13.907,11.027,12.093,16.374,10.361,11.536,8.794,-10.617,9.601,8.794,17.814,7.913,12.415,13.992,10.128 respectively,P =0.028,0.039,0.036,0.029,0.042,0.040,0.048,0.042,0.045,0.048,0.027,0.048,0.038,0.032,0.041 respectively).Conclusion The treatment of thyroid hormone for the edlerly patients with SCH has positive effects on theimprovement of mild cognitive impairment.

Objective To evaluate the factors which might affect the successful reopening of occluded subclavian artery. Methods During the period of Jan. 1998-March 2007, endovascular stent placement was performed in 20 patients with occluded subclavian artery, including 12 males and 8 females, aged 17-74 years (mean 53 years). The procedures were carried out by using super-slippery guide wire via anterograde or bilateral access. Results Successful reopening of occluded subclavian artery was obtained in 14 cases and the treatment ended in failure in 6 cases. In 14 patients with successful results, the mean length of diseased artery was 3.00 cm and the mean course of disease was 9.83 months, which were 2.13 cm and 27.6 months respectively in 6 cases of failure. The successful reopening rate was 80% in arthrosclerosis cases, while it was 50% in aorto-arteritis obliterans. The successful reopening rate was 100% in those cases whose occluded artery showing a sharp stump, while the successful reopening rate was 33% in those cases whose occluded artery showing a round stump, with a statistically significant difference between the two (P< 0.05). The successful rate in cases performed via anterograde access was 65%, and it was only 43% in cases performed via bilateral access. Conclusion The etiology, the duration of disease and the shape of stump bear a close relationship to the successful reopening rate, while no obvious correlation exists between the length of diseased artery and the reopening rate. Higher reopening rate can be achieved when the procedure is performed via anterograde access.

Attention Deficit Disorder with Hyperactivity ; diagnosis ; etiology ; therapy ; Child ; China ; Diagnosis, Differential ; Humans ; Time Factors

Objective To evaluate the clinical results of transjugular intrahepatic portosystemic shunt(TIPS)creation with 8 mm diameter covered stent-graft. Methods Ninteen concecutive patients with portal hypertension underwent TIPS creation with 8 mm diameter covered stent-graft for variceal bleeding and/or refractory ascites. Evaluation of the results through observing the improvement of clinical symptom and periodic follow up was carried out. Results Technical success achieved in all patients reaching 100% without related complications. Median follow-up was 13.5 months(ranged, 2.7 - 28 months). One case(1/19,5.3%)showed aggravation of hepatoencephalopathy and 2 others(2/19, 10.5%)revealed rebleeding. The primary patency rate was 100%(16/16)after 6 months, and 87.5%(7/8)after 12 months. Improvement or resolved rate of ascites was 66.7% (12/18). Conclusion TIPS creation with 8 mm diameter covered stent-graft can degrade the incidence of hepatic encephalopathy, improve the rate of TIPS patency and keeping the effective shunt flow.

Objective:To explore the value of uterine volume, ovarian volume (OV), endometrial thickness (ET) combined with ovarian hemodynamics in polycystic ovarian syndrome (PCOS).Methods:Fifty-three patients with PCOS diagnosed in the Third Affiliated Hospital of Wenzhou Medical University from October 2017 to October 2019 were selected as observation group and 53 healthy women of child bearing age who underwent physical examination at the same time were selected as control group. Patients with PCOS were divided into groups according to their different menopause times and ovalution statusafter ovulation promotion. The uterine volume, OV, ET, peak ovarian systolic velocity (PSV), ovarian artery resistance index (RI), and ovarian artery pulsation index (PI) was measured and recorded by transvaginal color Doppler ultrasound and compared between observation group and control group; and the above indicators in PCOS patients before and after chorionic gonadotrophin injection and 7 d after ovulation were compared.Results:Before treatment, the value of uterine volume, RI and PI of the observation group were lower than those of the control group: (30.28 ± 11.37) cm 3 vs. (38.41 ± 13.02) cm 3, 0.31 ± 0.04 vs. 0.73 ± 0.09, 0.86 ± 0.24 vs. 1.16 ± 0.32, the OV, ET, and PSV were higher than those of the control group: (15.04 ± 3.06) cm 3 vs. (6.35 ± 1.32) cm 3, (1.32 ± 0.41) mm vs. (0.64 ± 0.16) mm, (12.27 ± 2.83) cm/s vs. (9.37 ± 1.53) cm/s, and the differences were statistically significant ( P<0.05). Before treatment, the uterine volume and OV of PCOS patients had no significant differences in different menopause groups ( P>0.05). In menopause 10 - 15 d group, menopause 16 - 30 d group, menopause 31 -90 d group, and menopause>90 d group, the ET and PSV were gradually higher, the RI and PI were gradually lower, and the differences were statistically significant ( P<0.05). After ovulation promotion among 53 PCOS patients, 48 patients succeeded in ovulation promotion and 5 patients failed. On the day of chorionic gonadotrophin injection and mid luteal phase,the OV, ET and PSV in the successful ovulation induction group were lower than those in the failed ovulation induction group, and the uterine volume, RI and PI were higher than those in the failed ovulation induction group, and the differences were statistically significant ( P<0.05). In the successful ovulation induction group, the ET, RI, PI onthe day of chorionic gonadotrophin injection were lower than those onmid luteal phase, PSV was higher than that on mid luteal phase, and the differences were statistically significant ( P<0.05). Receiver operating characteristic (ROC)curveanalysis showed that that the area under the curve(AUC) of the value of uterine volume, OV, ET, and ovarian hemodynamic indicators joint examinationfor PCOS was 0.897 (95% CI 0.795 - 0.968), with a sensitivity of 95.0%, and a specificity of 80.2%, and all were higher than that of the single examination ( P<0.05). Conclusions:The value of uterine volume, OV, ET combined with ovarian hemodynamics are beneficial to observe the ovarian function of PCOS patients and the developmental potential of the basal layer of the endometrium, and have good application value for the evaluation of PCOS patients and guidance of clinical diagnosis and treatment.

Objective To explore the effect of interventional ward to the development of interventional radiology.Methods Investigation of the first class of the third grade hospitals in northeast region of China for the development status of interventional radiology in 2005 through questionnaires was undertaken.The hospitals were divided into two groups according to setting up interventional ward or not,together with comparative studies of number of doctors,sorts of interventional techniques and number of cases.Results Altogether 52 3rd grade,1st class hospitals have established interventional therapy,including with ward of 29(55.8%)and no ward of 23(44.2%);furthermore the average numbers of doctors in the forementioned two kinds of hospitals were 4.8 ? 1.7 vs 2.8 ? 1.5(P

Objective To study the expression changes and patterns of nucleic acid and their derivative metabolism,processing and transport-related genes in rat liver regeneration(LR) at transcriptional level. Methods The related genes were obtained by online data collection and literature review,and gene expression patterns in rat regenerated liver were checked by Rat Genome 230 2.0 array.LR-related genes were identified through the comparison of discrepancles in gene expression between partial hepatectomy(PH) and sham operation(SO) groups. Results 240 genes were determined to be related with liver regeneration.The number of initially expressive genes in the forepart of liver regeneration(0.5-4 hours after PH),prophase(6-12 hours after PH),metaphase(16-66 hours after PH),anaphase(72-168 hours after PH) were 65,14,150,11 respectively and the total expression numbers were 133,87,627,169 respeitirely.There were 6,5,22 and 9 expression patterns.Frequencies of up-regulation and down-regulation were 768 and 248.mRNA catabolism in prophase and metaphase,DNA recombination,modification and transcript,mRNA processing and transport in prophase,metaphase and anaphase,and nucleotides and their derivatives metabolism,as well as DNA replication,packaging and catabolism during the whole LR,were enhanced.Conclusion LR-related genes were mainly triggered in the forepart of liver regeneration,and funclioned at different phases.

Although the history of Interventional Radiology is no longer than 50 years,interventional techniques have been dramatically developed. Interventional radiologists have been responsible for much of the medical innovations and development of the minimally invasive procedures that are commonplace today to treat many complicated diseases as physicians. But the education backgrounds of interventional radiologist in China are different. Therefore,we should be aware that the job of an interventional radiologist is totally different from that of a diagnostic radiologist. It is very important to train interventional radiologists for improving their clinical thinking and clinical competence. Herein,we propose our suggestions on how to improve the clinical thinking and clinical competence of interventional radiologists. In this paper we also systemically introduce the accurate and proper treatment procedures which should be strictly followed in clinical work and,meanwhile,the perioperative patients care is emphasized.

The relationship between the dental occlusion and temporomandibular disorders (TMDs)has been one of the most controversial topics in the dental community.In a large epidemiological cross-sectional survey-the Study of Health in Pomerania (Germany)-associations between 1 5 occlusion-related variables and TMD signs or symptoms were found.In other investigations,additional occlusal variables were i-dentified.However,statistical associations do not prove causality.By using Hill's nine criteria of causation,it becomes apparent that the evi-dence of a causal relationship is weak.Only bruxism,loss of posterior support and unilateral posterior crossbite show some consistency across studies.On the other hand,several reported occlusal features appear to be the consequence of TMDs,not their cause.Above all,however, biological plausibility for an occlusal aetiology is often difficult to establish,because TMDs are much more common among women than men. Symptom improvement after insertion of an oral splint or after occlusal adjustment does not prove an occlusal aetiology either,because the a-melioration may be due to the change of the appliance-induced intermaxillary relationship.In addition,symptoms often abate even in the ab-sence of therapy.Although patients with a TMD history might have a specific risk for developing TMD signs,it appears more rewarding to fo-cus on non-occlusal features that are known to have a potential for the predisposition,initiation or perpetuation of TMDs.