1.Usefulness of Fully Automated Hematology Analyzer XE-5000 for Analysis in Samples with Low Platelet Counts
Tatsuya KAWASAKI ; Keiji FUNAHASHI ; Eiko YAMADA ; Koji KOJIMA ; Takashi ISOMURA ; Toshihito SUZUKI ; Kazuo EGUCHI ; Takao OZAKI
Journal of the Japanese Association of Rural Medicine 2014;62(5):701-706
The platelet counts documented in most of the studies using the fully automated hematology analyzer XE-5000 are values measured by impedance technology (PLT-I). If blood specimens showing an anomalous particle-size distribution curve in the area where platelet counts are low are used (exceptionally low platelet count samples), the counting method is automatically switched over to an optical method (PLT-O). In the present study, we examined the usefulness of the XE-5000 by comparing PLT-I with PLT-O, using blood samples with low platelet counts collected from patients who visited our hospital between January 1 and March 31, 2012. Dilution linearity left nothing to be desired in either of the two, but simultaneous reproducibility was higher in PLT-O than in PLT-I. The correlations of PLT-I and PLT-O with visual counts were high, working out at r=0.889~0.984. In the exceptionally low platelet count samples, the correlation coefficient was high in PLT-O than in PLT-I. The cases showing low platelet counts frequently presented giant platelets and/or red cell fragments. Therefore, measuring the samples with low platelet counts requires a high degree of precision. In the samples with exceptionally low platelet counts, PLT-O exceeded PLT-I in simultaneous reproducibility and correlation with visual counts. Thus, our study demonstrated the usefulness of the XE-5000 that could enumerate PLT-O automatically and speedily.
2.Implementation of Glucose Monitor System Following Introduction of Automated Ordering System
Yasuhiro SAIKI ; Fumie HIRASAWA ; Tatsuo ABE ; Kazuo EGUCHI ; Hideo FUKASAWA ; Hironobu KAKUTA
Journal of the Japanese Association of Rural Medicine 2004;53(4):679-684
Aichi Koseiren-Aihoku Hospital has implemented a New Glucose Monitoring System,using Precision PCx and its data management application, QC Manager (both Abbott Japan), for outpatient testing. It utilizes the advantages that have come with the introduction of the Ordering System. The new system has automated a great portion of glucose monitoring workflow and reduced the human work, and consequently, the potential risk of malfunction due to human errors. The system has been designed and developed to meet the following criteria; To be able to fully utilize the potential capabilities of the Ordering System (Barcode recognition of test samples); To be capable of transferring test results automatically to the Laboratory Information System without being handled by human; To improve the productivity as a whole system; To possess the precision and accuracy;and To be handled easily for bed-side use.
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3.Circulatory Support for the Operation of the Descending Thoracic Aorta with a Heparin-coated Tube and a Roller Pump.
Akira SAITO ; Shoji EGUCHI ; Jun-ichi HAYASHI ; Kazuo YAMAMOTO ; Hisanaga MORO ; Hajime OHZEKI
Japanese Journal of Cardiovascular Surgery 1992;21(5):515-518
We applied a new circulatory support system to three patients with descending aortic operation between 1989 and 1990. The new system consisted of a polyvinylchloride tube coated with hydrophilic heparinized polymer and a roller pump. Low doses of heparin (0.5mg/kg) were administered in two patients and none in one patient before aortic bypass. The aortic crossclamping time ranged between 52 and 64 minutes. In two patients, whose inflow cannulae were 18Fr. or 20Fr., successful bypass flow exceeded 2l/min and optimal distal aortic pressure were maintained during aortic cross-clamping. The postoperative courses of these patients were uneventful, free from thromboembolic episodes and subsequently discharged from hospital. Furthermore, postoperative careful examination revealed no thrombus formation occurred in the three devices. In conclusion, our new simple, antithrombogenic circulatory system is extremely useful for descending aortic operations.
4.A Case of Aorto-caval Fistula Due to Abdominal Aortic Aneurysm: The Effectiveness of Balloon Occlusion Catheter.
Shoh TATEBE ; Hajime OHZEKI ; Shoh-ichi TSUCHIDA ; Jun-ichi HAYASHI ; Akira SAITOH ; Kazuo YAMAMOTO ; Takehiro WATANABE ; Manabu HAGA ; Shoji EGUCHI
Japanese Journal of Cardiovascular Surgery 1992;21(6):605-608
A case of 65-year-old man of aorto-caval fistula induced by ruptured abdominal aortic aneurysm is reported. The symptoms were hematuria and chest pain, and an emergent operation was performed. In the operation, Fogarty's balloon occlusion catheter was used to reduce bleeding from inferior vena cava, and to prevent pulmonary embolism. The fistula was 3cm in size, and abdominal aorta was replaced with a low porosity polyester Y-graft. The symptoms of pulmonary congestion and hematuria were improved after operation. The balloon occlusion catheter was effective for reducing bleeding from IVC, and prevention from pulmonary embolism after operation.
5.Evaluation of the Model Core Curriculum for Clinical Clerkship
Yoshifumi ABE ; Eiji GOTOH ; Mitsuoki EGUCHI ; Nagayasu TOYODA ; Kazuo ITOH ; Yutaka INABA ; Ryozo OHNO ; Tadahiko KOZU ; Yuichi TAKAKUWA ; Yuko TAKEDA ; Masahiro TANABE ; Nobutaro BAN ; Osamu MATSUO ; Osamu FUKUSHIMA ; Hiromichi YAMAMOTO
Medical Education 2004;35(1):3-7
In March 2001, Research and Development Project Committee for Medical Educational Programs proposed a model core curriculum for undergraduate medical education. In this curriculum, implementation of the clinical clerkship is strongly recommended. Two similar curriculum models were later presented by other organizations, and some differences were observed among them. We, Undergraduate Medical Education Committee, have evaluated and compared themodel core curriculum 2001 with the Japanese newer proposals as well as those of USA and UK. Here is reported our proposals for a better rewriting of the learning objectives in the model core curriculum 2001, with some emphasis on the nurture of the competence of the case presentation and decision making process.
6.Desirable Educational Environment for the Better Clinical Clerkship
Hiromichi YAMAMOTO ; Yuko Y TAKEDA ; Masahiro TANABE ; Yoshifumi ABE ; Eiji GOTOH ; Tadahiko KOZU ; Ryozo OHNO ; Kazuo ITOH ; Yutaka INABA ; Mitsuoki EGUCHI ; Yuichi TAKAKUWA ; Nagayasu TOYODA ; Nobutaro BAN ; Osamu FUKUSHIMA ; Osamu MATSUO
Medical Education 2004;35(1):9-15
In order to implement, or enhance the quality of clinical clerkship, it is necessary to develop good educational environment which will be appropriate to allow medical students participate in medical team services. Important things to be considered will be, (1) Systematic management of the individual department's program by the faculty of medicine, (2) Developing educational competency within the medical care team function, and (3) Nurturing students' awareness forself-diected learning and cooperative team work, and teaching- and medical staffs' awareness of their educational responsibilities. In this paper, to develop better educational environment for clinical clerkship, we propose a desirable situation of the educational organization, dividedly describing on the roles of dean, faculties, board of education, department of medical education, clerkship director, teaching physicians, residents and medical students.
7.Data Intensive Study of Accessibility of Edible Species and Healthcare Across the Globe
Satoshi WATANABE ; Hoko KYO ; KANG LIU ; Ryohei EGUCHI ; Md. ALTAF-UL-AMIN ; Aki MORITA(HIRAI) ; Minako OHASHI ; Naoaki ONO ; Alex Ming HUANG ; Yanbo ZHU ; Qi WANG ; Zhaoyu DAI ; Yukiko NAKAMURA ; Klaus W. LANGE ; Kazuo UEBABA ; Shintaro HASHIMOTO ; Shigehiko KANAYA ; Nobutaka SUZUKI
Japanese Journal of Complementary and Alternative Medicine 2018;15(1):37-60
Variety of accessibility to edible species in different regions has climatic and historical roots. In the present study, we try to systematically analyze 28,064 records of relationships between 11,752 edible species and 228 geographic zones by hierarchical clustering. The 228 geographic regions were classified into 11 super groups named as A to K, which were further divided into 39 clusters (CLs). Of them, at least one member of each of 28 CLs is associated to 20 or more edible species according to present information of KNApSAcK DB (http://kanaya.naist.jp/KNApSAcK_World/top.jsp). We examined those 28 CLs and found that majority of the members of each of the 27 CLs (96%) have specific type of climate. Diversity of accessibility to edible species makes it possible to separate 8 geographic regions on continental landmasses namely Mediterraneum, Baltic Sea, Western Europe, Yucatan Peninsula, South America, Africa and Arabian Peninsula, Southeast Asia, and Arctic Ocean; and three archipelagos namely, Caribbean Islands, Southeast Asian Islands and Pacific Islands. In addition, we also examined clusters based on cultural exchanges by colonization and migration and mass movement of people and material by modern transportation and trades as well as biogeographic factors. The era of big data science or data intensive science make it possible to systematically understand the content in huge data and how to acquire suitable data for specific purposes. Human healthcare should be considered on the basis of culture, climate, accessibility of edible foods and preferences, and based on molecular level information of genome and digestive systems.
8.Determination of Optimum Number of Groups on the Crowdsourcing Survey in Japanese People Interpreted by Physical Constitution Defined by CCMQ-J
Mariko SATO ; Toshihiro KAWASAKI ; Ming HUANG ; Hoko KYO ; Naoaki ONO ; Ryouhei EGUCHI ; Md. ALTAF-UL-AMIN ; Saki TOKUDA-KAKUTANI ; Hiroshi WATANABE ; Norihito MURAYAMA ; Satoshi NAKAMURA ; Shiori YAMAGUCHI ; Hiroki TANAKA ; Shigehiko KANAYA ; Yanbo ZHU ; Zhaoyu DAI ; Qi WANG ; Kazuo UEBABA ; Nobutaka SUZUKI
Japanese Journal of Complementary and Alternative Medicine 2019;16(2):105-112
Chinese Medicine Questionnaire (CCMQ-J) consists of sixty independent questionnaires and 9 physical constitutions called subscales. One type is balanced constitution (i.e., gentleness), and the following eight types represent unbalanced constitution: Qi-deficiency constitution, Yang-deficiency constitution, Yin-deficiency constitution, Phlegm-dampness constitution, Damp-heat constitution, Stagnant Blood constitution, Stagnant Qi constitution, and Inherited Special constitution. In this study, we proposed to determine optimal number of groups in 851 participants recruited from crowdsourcing answered CCMQ-J questionnaire consisting of 60 questions. In the present study, we applied k-means clustering with gap statistics to the questionnaire data and the number of optimal groups was estimated by five. The five groups are mainly characterized by 3 subscales in CCMQ-J, i.e. (i) two subscales corresponding to Yang-deficiency and Qi-depress, (ii) three subscales corresponding to gentleness, Yang-deficiency and Qi-depress (iii) Yang-deficiency, (iv) gentleness, and (v) Qi-depress. In the crowdsourcing survey, two subscales, Yang-deficient and Qi-depress are the most frequently occurred in current Japanese people.