It has been demonstrated that exercise induces heat shock proteins (HSPs) . However, no study has investigated changes in HSPs following endurance training at different speeds. Therefore, this study was designed to investigate the effect of treadmill training at different running speeds on induction HSPs. One group of male Wistar rats was assigned as a sedentary control, three groups were assigned for exercise training (10 m/min, 20 m/min and 30 m/min) and another three groups for one acute bout of exercise (10 m/min, 20 m/min and 30 m/min) . Each training group ran at each speed for 30 min/day, 5 days a week for 8 weeks. The acute exercise group performed the exercise only once. Forty-eight hours after the last exercise session was completed, the rats were sacrificed and the plantaris (PLA) and soleus (SOL) muscles were dissected. In the acute exercise group, the content of HSP72 in both the PLA and SQL increased (p<0.05) at all speeds, and the content of HSP60 increased significantly (p<0.05) at all speeds for the PLA, but not for the SOL. On the other hand, in the endurance group, the content of HSP72 and HSP60 in both muscles increased in 30 m/min groups. These results indicate that an increase in HSP72 and HSP60 by endurance training is induced by high intensity training in both muscles. This was not found to be the case with the acute exercise groups.

As you know, we have met with the patients suffered from cervical spondylosis with so to speak paresthesia in daily living. We planned, this time, to search for how clinical assessment about like that kind of paresthesia was to be in practical scene.
The subjects of this studies, they were cared in the out-patient programs, the department of rehabilitation medicine at Teikyo University, 26 cervical spondylosis patients complained of any paresthesia on their arms.
In the first place, to clarify the differences between the normal and patient groups clinicaly, we were planing to check and count sensory and motor conduction velocity, somato-sensory evoked potential and latency of each component. And then, plethysmogram was also checked but decidedly, there was no significant difference between the normal and innormal group statistically.
Accordingly, it has become clear that we had so many items which was to be solved scientifically in these investigations. And that we got to know its difficulities and possibilities to put like this clinical assessment in practice.

Inserting a tangusten microelectrode into the peroneous nerve of the conscious human subject, the authors recorded the discharge of primary afferent C and A δ fibers. Most of the C fibers belonged to the polymodal group, as these were excited by both mechanical and thermal stimulations. These units responded to painful mechanical or thermal stimuli, as well as to non-painful stimuli of these modalities. These polymodal receptors were capable of responding to a wide range of stimulation intensity.
Only some of the Aδ fibers responded to mechanical stimulation of a high intensity and painful thermal stimulation. These units increased their discharge to repeated heat administration showing a marked sensitization. This sensitization corresponded to the sense of increased heat experience by the human subjects who had hyperalgesia from the increasing heat. These findings indicate that these Aδ afferent fibers transmit sensation of hyperalgesia from the hairy skin to the higher centers.

Muscle tenderness or stiffness is generally attributed to local muscle spasm or aggravated tonus however electro-myographic studies have indicated no spontaneous discharge as usual and any kind of change of N M U weve patterns, certainly. There is a great deal of uncertainty about the fundamental chracter, identified factor of these conditions.
To analize (_??_-S curves) -the mean inteerval (_??_) of the single unit NMU discharges and the standard deviation (S) of the same it was learned that these phenomena could be classified into two types of muscle activities, the one is kinetic activity (K-curve) and the other is tonic one (T-curve) so to speak. We conducted examinations concerning about the character of the notor unit activity of the trigger point in low back pain patient with _??_-S relation. In comparison with the distribution of (_??_-S) of the low back pain patient group (14 patients, 295 units) and that of the control group most (_??_) was up to about 120 msec. with (S) relatively stable, an almost horizontal distribution along the x-axis with an increase when (_??_) was any larger.
As compared to this, in most examples in the lumbago group (_??_) was horizontally up to 120 msec. after which a gradual rise xas indicated. The various distributions showed that that of the lumbago group was moved to the right of the awis of co-ordination as was the recovery line. Consequently, we observed that the NMU discharges of the trigger point in low back pain patients showed more tonic activity than that of normal subjects. And this finding strongly indicates that voluntary muscular activity in trigger points is under the predominant influence of spinal motoneuron than homonymous neuron segmentally.

Aim: The usefulness and safety of strontium chloride (89Sr), a radiopharmaceutical agent for painful bone metastasis, varies from patient to patient, but the reasons for why the usefulness and safety vary have not been elucidated. The purpose of this study is to explore the background factors of patients who experienced pain relief or bone-marrow suppression after 89Sr was administrated. Methods: In the cases of pain relief, we divided the results from a numeric rating scale (NRS) before and after 89Sr administration into effective and ineffective groups as outcomes. In the cases of bone-marrow suppression, we analyzed neutrophil cells, blood platelets, and hemoglobin levels, respectively, before and after 89Sr administration as outcomes. Then, we performed statistical analyses on both case groups. Results: The results showed that the background factors associated with pain relief were weight, the 89Sr dosage amount, NRS, eGFR, SCr, and Ca levels before 89Sr administration and the area of bone metastasis (number of sites reached). We found that background factors associated with bone-marrow suppression have a moderate significant correlation with hemoglobin, NRS, and SCr levels before 89Sr administration after investigating factors which influence neutropenia. In the case of thrombocytopenia, there was a moderate significant correlation with platelet counts before 89Sr administration. In the case of hypochromia, there was a moderate significant correlation with hemoglobin levels before 89Sr administration. Discussion: Our study could elucidate patient background factors associated with pain relief and bone-marrow suppression after 89Sr administration.

BACKGROUND: Studies on the adverse effects of Asian dust (AD) on respiratory function in children are scarce. The objective of this study was to examine the association between AD and respiratory function by measuring peak expiratory flow rates (PEFRs) in asthmatic children. METHODS: The study was carried out from March to May from 2014 through 2016. One hundred ten children with bronchial asthma were recruited from four hospitals in the Goto Islands and south Nagasaki area in Nagasaki prefecture. The parents were asked to record their children's PEFRs every morning/evening and clinical symptoms in an asthma diary. AD was assessed from light detection and ranging data, and a linear mixed-effects model was used to estimate the effects of AD on daily PEFR. Time-stratified case-crossover analyses were performed to examine the association between AD and asthma attacks defined by reduction levels in PEFR. RESULTS: AD was detected on 11 days in the Goto Islands, and on 23 days in the south Nagasaki area. After adjusting for age, sex, temperature, and daily oxidants, we found a consistent association between AD and a 1.1% to 1.7% decrease in PEFR in the mornings and a 0.7% to 1.3% decrease in the evenings at a lag of 0 to 5 days. AD was not associated with the number of asthma attacks, respiratory symptoms, or other symptoms at any lag days examined. CONCLUSIONS Exposure to AD was associated with reduced PEFR, although the effects were not large enough to induce clinically apparent symptoms, in clinically well-controlled asthmatic children.