1.Usage of Orengedokuto for Hemorrhage Uncontrolled by Western Medicine
Masahiro SAKATA ; Kazuaki YAKUSHIJI ; Shinichirou KUROKAWA ; Yuiko SAIKUSA ; Ryuusuke SHIN ; Takefumi FUJIMOTO ; Kan KOMAI ; Tomomi SANO ; Junko KAMEO ; Chie KIYOKAWA ; Hiromi IWAGAKI ; Minoru YAGI ; Hideaki EGAMI
Kampo Medicine 2017;68(1):47-55
Orengedokuto, a Kampo formulation, has traditionally been used to treat various diseases, including hypertension with neuropsychiatric symptoms, gastritis, dermatitis, hematemesis and hemorrhagic stools. We report 8 cases of intractable hemorrhage that could not be controlled by Western medicine, but were successfully treated with orengedokuto. We elaborate on 3 cases, including 1 case treated by enema administration of orengedokuto, which was found to be a useful method. In a representative case, an 80-year-old man with aplastic anemia who was taking anticoagulants due to a history of mitral valve replacement presented with a chief complaint of black stool. Hemorrhagic gastritis was diagnosed. We repeatedly attempted endoscopic hemostatic therapy, but failed to achieve hemostasis. Oral administration of orengedokuto demonstrated hemostatic effects within a few days of starting treatment. In all 8 these cases, moreover, we observed quick clinical responses with no side effects. Although the hemostatic mechanism of orengedokuto remains unclear, we speculate that orengedokuto contains a short-acting component that affects primary hemostasis. As such, conventional orengedokuto may also have potential as a novel hemostatic agent.
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