The purpose of this study was to clarify the characteristics of the ability of aerobic and anaerobic power output and the muscle thickness at each site of varsity kayak paddlers. Twenty-three male kayak paddlers who divided into skilled and unskilled group by their career participated in this study. Maximal oxygen uptake as a measure of aerobic power was determined with a progressive arm cranking exercise. Four all-out ergometer work tests lasting 7 and 40 seconds were used to estimate anaerobic alactic power and anaerobic lactic power with leg (pedaling) and arm (cranking) exercises. Anaerobic alactic power (AAP) was computed as the highest power output during 7 seconds and anaerobic lactic power (ALP) was obtained as the mean power output during 40 seconds. Muscle thickness were measured by B-mode ultrasonography at 11 sites on the body. Maximal oxygen uptake of skilled paddlers (3.501/min) was significantly higher than that of unskilled ones (2.701/min) . Similarly, there were significant differences between skilled and unskilled paddlers in AAP and ALP, especially as measured by the arm cranking exercise. The results showed that the career of arm-specific training induced the large specificity of aerobic and anaerobic power output with arm cranking mode. Muscle thickness of skilled paddlers were significantly larger than those of unskilled paddlers at sites on the biceps, abdomen, back muscles, quadriceps and hamstrings, and these strongly correlated with aerobic and anaerobic power output. It is suggested that for the improvement in power output it was necessary to train the muscles of trunk and thigh, and have a specific exercise mode.

The purpose of this study was to examine the effects of off-season training on the anaerobic power output and muscle thickness of male varsity rowers. 23 rowers participated in this study. Four all-out cycle ergometer work tests lasting 7 and 40 seconds were used to estimate anaerobic alactic power (AAP) and anaerobic lactic power (ALP) with leg (pedaling) and arm (cranking) exercises. AAP was computed as the highest power output during 7 seconds and ALP was obtained as the mean power output during 40 seconds. Muscle thickness was measured by B-mode ultrasonography at 11 sites on the body. There were significant differences between before and after off-season training in AAP (cranking : 8.4±1.00 vs 9.2±1.10W /kg, p<0.001, pedaling: 14.4± 1.10 vs 15.0±1.00 W/kg, p<0.001) and ALP (cranking : 5.2±0.42 vs 5.5±1.20W/kg, p<0.001, pedaling: 10.1±0.62 vs 9.5±2.10 W/kg, n, s.) . Muscle thickness increased significantly as a result of off-season training at sites on the biceps, triceps, pectoralis major, subscaplar and hamstrings. Similarly, there were significant differences in estimated muscle cross-sectional area (MCSA) on sites on the elbow flexor (20.6±2.6 vs 22.1±1.8cm², p< 0.01), elbow extensor (25.3 ±4.8 vs 28.6±4.2cm², p<0.001) and knee flexor (71.1±5.8 vs 74.3±5.2cm², p<0.01) . The main training program in the off-season consisted of resistance training of the whole body. The high intensity training, used by male varsity rowers during off-season training, increased arm AAP, leg AAP, arm ALP and muscle thickness of the upper body ; but there was no difference in leg ALP and knee extensor muscle. It was suggested that improvements in leg ALP and knee extensor muscle are necessary to during the off-season training program of male varsity rowers.

Disease risk among elderly smokers is considered to be doubled due to their smoking habits and age as compared with elderly non-smokers. The investigators conducted risk assessments of smoking for respiratory symptoms among elderly people.A questionnaire survey on smoking habits and respiratory symptoms was conducted among 3, 000 persons of 56 years of age and over who were randomly selected from suburban residents in a prefecture in Japan in October, 1997. A total 1, 954 or 65.1% of individuals responded, consisting of 42.8% for men and 57.2% for women, with an average age of 73.6 years.In addition to descriptive analysis, multiple logistic regression analysis was conducted. The results are summarized as follows:Smokers accounted for 28.1% of men and 3.6% of women. Among all age-groups, the highest rate of smokers was observed in men of 56-69 years old (34.7%) which was lower than the national average rate for the 60-69 year-old group (56.1% of men and 14.5% of women in ‘97). The odds ratios and 95 percent confidence interval (95%CI) for “having phlegm every day” and “having phlegm for more than 4 days a week” among smokers were 2.06 (95%CI=1.41-3.01) and 2.77(95%CI=1.80-4.27). Significantly higher odds ratios among smokers were also observed for “wheezing” and “shortness of breath when hurrying”.Odds ratios for some respiratory symptoms including “having phlegm for more than 4 days per week” among inhalers were significantly high compared with non-smokers, whereas those among non-inhalers were not significantly different from 1.0.Odds ratios for symptoms of phlegm and wheezing were significantly higher (Odds ratio ≥2.0) among heavy smokers (Brinkman Index [B. I.] >900) compared to non-smokers, while odds ratios of the same symptoms were not different from 1.0 among light smokers (B.I. ≤500).
symptoms <1> ; Respiratory ; Smoking ; Elderly ; Male population group

Objective: This study aimed to elucidate the electro-clinical characteristics of epilepsy and immunological markers in patients with epilepsy after infl uenza-associated encephalopathy/encephalitis (IAE). Methods: Eighteen patients with epilepsy after IAE (8 males, 10 females; mean age of onset 6.4±6.4 years) were studied. Antibodies to glutamate receptor (GluR) ε2 (NR2B) were examined by immunoblot and ELISA. Cytokines were measured by BioPlex. Results: Mean interval between IAE and epilepsy onset was 63.2 ± 95.0 days (mean ± SD). In 16 of 18 patients, complex partial seizures were observed. Most complex partial seizures were of short durations and showed few lateralizing signs. Interictal discharges were seen in the frontal area in 7 of 14 patients. Ictal EEG showed rapid propagation to bilateral hemispheres. Patients with higher cerebrospinal fl uid levels of anti-GluRε2 antibodies, higher cerebrospinal fl uid levels of IL-1β, soluble tumor necrosis factor receptor 1 and IFN-γ during chronic stage, had higher frequency of epileptic seizures. Conclusion: This study indicates that the frontal lobes are susceptible to rapid epileptogenesis after IAE, and that epileptic partial seizures after IAE had characteristics resembling generalized seizures. Presence of anti-GluRε2 antibodies and elevated IL-1β, TNFα, and IFN-γ in cerebrospinal fl uid may be associated with intractability of epileptic seizures.

PURPOSE: To evaluate the efficacy of using 3-tesla (T) magnetic resonance imaging (MRI) diagnosis of extracapsular extension (ECE) for decision-making about neurovascular bundle (NVB) preservation in robot-assisted radical prostatectomy (RARP) for prostate cancer (PC). MATERIALS AND METHODS: We prospectively collected data on PC patients (n=67) who underwent preoperative 3-T MRI before RARP. The choice between nerve sparing or resection was based on 3-T MRI findings of ECE. We compared the MRI findings with the pathological data on surgical margins. Our clinical staging in this study was defined only by MRI. RESULTS: When the data were divided by prostate lobe (right lobe or left lobe, n=134), 3-T MRI showed 28 positive cases of ECE in 134 prostate lobes, allowing NVB preservation in 42 cases (31.3%). Nerve-sparing surgery was achieved in 38.7% of cases in which clinical T2 staging by MRI was reported. The pathological data revealed that 10 of 134 prostate lobes had positive ECE. The overall sensitivity, specificity, positive predictive value, and negative predictive value for predicting stage T3 (positive ECE) by side were 60.0% (12 of 20 sides), 86.0% (98 of 114 sides), 42.9% (12 of 28 sides), and 92.5% (98 of 106 sides), respectively. CONCLUSIONS: Three-T MRI prior to RARP enables the use of ECE diagnosis to guide decision-making about NVB preservation, with comparatively high specificity and negative predictive value. Further prospective studies are underway to reach more definitive conclusions.
Humans ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Magnetics ; Magnets ; Prospective Studies ; Prostate ; Prostatectomy ; Prostatic Neoplasms ; Robotics ; Sensitivity and Specificity

OBJECTIVE: To compare the survival outcomes of patients with cervical squamous cell carcinoma (SCC) and adenocarcinoma/adenosquamous carcinoma (AC/ASC) among patients with locally advanced cervical cancer that were treated with definitive radiotherapy. METHODS: The baseline characteristics and outcome data of patients with locally advanced cervical cancer who were treated with definitive radiotherapy between November 1993 and February 2014 were collected and retrospectively reviewed. A Cox proportional hazards regression model was used to investigate the prognostic significance of AC/ASC histology. RESULTS: The patients with AC/ASC of the cervix exhibited significantly shorter overall survival (OS) (p=0.004) and progression-free survival (PFS) (p=0.002) than the patients with SCC of the cervix. Multivariate analysis showed that AC/ASC histology was an independent negative prognostic factor for PFS. Among the patients who displayed AC/ASC histology, larger tumor size, older age, and incomplete response to radiotherapy were found to be independent prognostic factors. PFS was inversely associated with the number of poor prognostic factors the patients exhibited (the estimated 1-year PFS rates; 100.0%, 77.8%, 42.8%, 0.0% for 0, 1, 2, 3 factors, respectively). CONCLUSION: Locally advanced cervical cancer patients with AC/ASC histology experience significantly worse survival outcomes than those with SCC. Further clinical studies are warranted to develop a concurrent chemoradiotherapy (CCRT) protocol that is specifically tailored to locally advanced cervical AC/ASC.
Adenocarcinoma ; Carcinoma, Adenosquamous ; Carcinoma, Squamous Cell* ; Cervix Uteri ; Chemoradiotherapy ; Disease-Free Survival ; Epithelial Cells* ; Female ; Humans ; Multivariate Analysis ; Radiotherapy* ; Retrospective Studies ; Uterine Cervical Neoplasms*

STUDY DESIGN: Retrospective case series. PURPOSE: To investigate the oncological outcomes, including distant relapse, after en bloc spondylectomy (EBS) for spinal metastases in patients with a minimum of 2-year follow-up. OVERVIEW OF LITERATURE: Although EBS has been reported to be locally curative and extend survival in select patients with spinal metastases, detailed reports regarding the control of distant relapse after EBS are lacking. METHODS: We conducted a retrospective review of 18 consecutive patients (median age at EBS, 62 years; range, 40–77 years) who underwent EBS for spinal metastases between 1991 and 2015. The primary cancer sites included the kidney (n=7), thyroid (n=4), liver (n=3), and other locations (n=4). Survival rates were estimated using the Kaplan–Meier method, and groups were compared using the log-rank method. RESULTS: The median operative time and intraoperative blood loss were 767.5 minutes and 2,375 g, respectively. Twelve patients (66.7%) experienced perioperative complications. Five patients (27.8%) experienced local recurrence of the tumor at a median of 12.5 months after EBS, four of which had a positive resection margin status. Thirteen patients (72.2%) experienced distant relapse at a median of 21 months after EBS. The estimated median survival period after distant relapse was 20 months (95% confidence interval, 0.71–39.29 months). No association was found between resection margin status and distant relapse. Overall, the 2-year, 5-year, and 10-year survival rates after EBS were 72.2%, 48.8%, and 27.1%, respectively. Importantly, the era in which EBS was performed did not impact the oncological outcomes. CONCLUSIONS: Our results suggest that EBS by itself, even if margin-free, cannot prevent further dissemination, which occurred in >70% of patients at a median of 21 months after EBS. These results should be considered and conveyed to patients for clinical decision-making.
Clinical Decision-Making ; Follow-Up Studies ; Humans ; Kidney ; Liver ; Methods ; Neoplasm Metastasis ; Operative Time ; Recurrence ; Retrospective Studies ; Spine ; Survival Rate ; Thyroid Gland