Acral lentiginous melanoma (ALM) is a rare subtype of cutaneous melanoma, primarily affecting individuals with darker skin. This case series presents four unique instances of nodular ALM, highlighting the association of trauma with disease progression, a factor underreported in existing literature.

We report four patients aged 30 to 72 years, each presenting with nodular masses that evolved from stable pigmented lesions. Notably, all cases followed a history of trauma, resulting in significant clinical features such as rapid lesion growth and associated lymphadenopathy. Histopathological evaluations confirmed atypical melanocyte nests and pagetoid spread in all cases, reinforcing the diagnosis of nodular melanoma.

This series underscores the importance of recognizing the nodular presentations of ALM, particularly in patients with a history of trauma, which may lead to misdiagnosis and delayed treatment. The findings reveal a younger demographic, with an average age of 55.3 years, challenging prior assumptions about ALM’s typical patient profile. The critical takeaway is the necessity for heightened awareness and thorough diagnostic evaluation in similar cases to ensure timely intervention and improved patient outcomes. Our observations advocate for further research to elucidate the relationship between trauma and ALM progression.

Human ; Adult: 25-44 Yrs Old ; Middle Aged: 45-64 Yrs Old ; Aged: 65-79 Yrs Old ; Tumors ; Neoplasms

Lupus vulgaris is a form of cutaneous tuberculosis (CTB) caused by Mycobacterium tuberculosis (MTB). It is characterized by a usually solitary, long-lasting skin lesion that most commonly develops on the head or neck, especially the nose, cheek, earlobe, or scalp.

A 69-year-old elderly, Filipino female presented with a 20-year history of progressively growing erythematous ulcerative plaques on the right arm and ear, with associated mild pruritus and pain. She appeared to be immunocompetent and had no clinically apparent underlying focus of TB infection. Tuberculin skin test (TST) showed a positive reaction and histopathologic examination revealed a chronic granulomatous dermatitis that is focally positive for acid-fast bacilli (AFB). She was given anti-koch’s therapy with subsequent resolution of the lesions.

The case report presents a rare instance of lupus vulgaris (LV) in a Filipino woman, characterized by large, ulcerative plaques on her body with no apparent infection source, emphasizing the need for early detection and Quantiferon-TB Gold (QFT-G) testing for diagnosis.

Human ; Female ; Aged: 65-79 Yrs Old ; Lupus Vulgaris

Acrodermatitis enteropathica is a rare autosomal recessive disease that results from a defect in zinc metabolism. It is clinically characterized by a phenotypic triad of periorificial and acral dermatitis, diarrhea, and alopecia. Oral zinc therapy gives a rapid excellent clinical response and reduces mortality. We report three female pediatric siblings who presented with periorificial and acral dermatitis, diffuse alopecia, nail dystrophy, irritable mood, and stunted growth. A diagnosis of acrodermatitis enteropathicawas confirmed with markedly decreased levels of serum zinc. The patients were successfully treated with oral zinc sulfate at a dose of 5mg/kg/day for the first two weeks then maintained on a dose at 2mg/kg/day.
Zinc ; Blister