AIM: To determine the frequency of dry eye in computer users and to compare them with control group.METHODS: This study was a case control research conducted in 2015 in the city of Birjand.Sample size of study was estimated to be 304 subjects (152 subjects in each group,computer user group and control group).Non-randomized method of sampling was used in both groups.Schirmer test was used to evaluate dry eye of subjects.Then,subjects completed questionnaire.This questionnaire was developed based on objectives and reviewing the literature.After collecting the data,they were entered to SPSS Software and they were analyzed using Chi-square test or Fisher`s test at the alpha level of 0.05.RESULTS: In total,304 subjects (152 subjects in each group) were included in the study.Frequency of dry eyes in the control group was 3.3% (5 subjects) and it was 61.8% in computer users group (94 subjects).Significant difference was observed between two groups in this regard (P<0.001).The frequency of eye symptoms in the control group was 7.9% (n=12),and it was 34.2% in computer users group (n=52),which significant difference was observed between two groups in this regard (P<0.001).Frequency of dry eye syndrome in computer users by gender and age groups showed no significant correlation in this regard (P=0.8).The mean working hour with computer per day in patients with dry eye was 6.65±3.52h,while it was 1.62±2.54h in healthy group (T=13.25,P<0.001).CONCLUSION: This study showed a significant relationship between using computer and dry eye and ocular symptoms.Thus,it is necessary that officials need to pay particular attention to working hours with computer by employees.They should also develop appropriate plans to divide the working hours with computer among computer users.However,due to various confounding factors,it is recommended that these factors to be controlled in future studies.

Nilotinib as a tyrosine kinase inhibitor has been recently used to improve the liver fibrosis process, but the exact mechanisms still require further clarification. In this study, we investigated the anti-fibrotic effects of Nilotinib via RAGE/HMGB1axis and antioxidant mechanisms. This experimental study was performed in the Hamadan University of Medical Sciences, Iran, from May 2015 to December 2016. Liver fibrosis was induced in Wistar male rats by CCL₄. Rats were gavaged daily with Nilotinib (10 mg/kg). RAGE, HMGB1, TNF-α and TGF-β mRNA expression were evaluated by quantitative RT-PCR. TNF-α protein levels were measured using the immunoassay method. Thiol groups, carbonyl groups, nitric oxide levels and glutathione peroxidase activity were measured by spectrophotometric methods.The results showed that Nilotinib decreased TNF-α, TGF-β, RAGE and HMGB1 mRNA expression (p<0.001) in the liver tissues of the fibrosis group. Nilotinib also decreased carbonyl groups and nitric oxide levels and increased thiol groups and glutathione peroxidase activity in the fibrosis groups. The histopathological changes were found to be attenuated by Nilotinib. In conclusion, Nilotinib can improve liver fibrosis and open new mechanisms of the anti-fibrotic properties of Nilotinib.
Animals ; Fibrosis ; Gene Expression ; Glutathione Peroxidase ; HMGB1 Protein ; Humans ; Immunoassay ; Iran ; Liver Cirrhosis ; Liver ; Male ; Methods ; Nitric Oxide ; Oxidative Stress ; Protein-Tyrosine Kinases ; Rage ; Rats ; RNA, Messenger