The present study investigated the effect of moxibustion for 4 weeks on insulin resistance in Otsuka-Long-Evans Tokushima Fatty (OLETF) rats, a model of spontaneous noninsulin-dependent diabetes mellitus (NIDDM). Glucose infusion rate (GIR) in the moxibustion group was higher than that in the control group. This finding suggests that moxibustion may be effective for insulin resistance.