Objective To evaluate Chinese children’s blood lead levels(BLLs) and identify the distribution features with time and to provide the data for developing the policy to control environmental lead pollution.Methods The papers on children BLLs published from 2004 to Aug.2007 with sampling time since 2001 were collected,by searching Chinese Biomedical Disk(CBMDisk),Chinese Journal Full-test Database(CJFD) and other ways.Thirty-five articles eligible for inclusion criteria were reviewed.Also,the data were compared with our former study carried out in 2004 with articles studying time between 1995 and 2003.Results The mean BLL of Chinese children between 2001 and 2007 was 80.7 ?g/L(45.5-165.3 ?g/L),and 23.9%(3.2%-80.7%)were higher than 100 ?g/L,both of which were lower than the levels in 1995 to 2003.Four of 24 provinces or cities reported had average BLLs≥100 ?g/L.Of the 24 provinces or cities,only four had higher BLL and prevalence rates of lead poisoning(BLL ≥100 ?g/L) than that in 1995 to 2003.The mean BLL of children living in industrial areas was higher than that of children in urban and suburbs areas,and the mean BLL in suburbs was higher compared with urban areas.Boys BLL was 79.3 ?g/L,significantly higher than girls(76.9 ?g/L)(P

Objective To investigate the relationship between hypoxia-related genes and ischemic stroke,and to screen for molecular markers related to hypoxia. Methods First,GSE16561 and GSE58294 datasets and hypoxia-related gene sets were downloaded to screen for hypoxia-related differentially expressed genes. After functional annotation,these hypoxia-related differentially expressed genes were analyzed by the least absolute shrinkage and selection operator least absolute shrinkage and selection operator(LASSO) regression and support vector machine algorithm to screen for immune-related biomarkers,and differential immune cells were analyzed between the ischemic stroke group and the control group. Finally,transcription factors and miRNAs were predicted. Results A total of 13 hypoxia-related differentially expressed genes were screened,which were enriched mainly in the processes of glucose transmembrane transport,monosaccharide transmembrane transport,and mitophagy regulation. Based on the LASSO regression and support vector machine algorithm analyses,eight hypoxia-related biomarkers were identified,which were significantly correlated with most immune cells. Furthermore,the network of 209 transcription factors corresponding to 8 genes and 25 miRNAs corresponding to 6 genes were predicted. Conclusion Eight hypoxia-related biomarkers are identified,which may be used as potential therapeutic targets for inhibiting brain injury after stroke. In addition,glucose metabolism and immune mechanisms may play an important role in the occurrence and progression of ischemic stroke.

Objective To explore the impact of vascular calcification on patency rate of arteriovenous fistula(AVF)after ultrasound-guided percutaneous transluminal angioplasty(UG-PTA)for stenosis.Methods Forty-eight chronic kidney disease patients who underwent maintenance hemodialysis(HD)and received UG-PTA since autologous or artificial AVF stenosis were retrospectively enrolled.The patients were divided into calcification group(n=21)and non-calcification group(n=27)according to ultrasonic findings of AVF calcification or not.The technical success rate of UG-PTA,the clinical success rate and UG-PTA related adverse events were recorded.Ultrasound was performed to evaluate the patency of AVF 3,6,9,12,24 and 36 months after UG-PTA,and the primary and secondary patency rates were calculated.Kaplan-Meier survival curves were used to analyze the patency rates of AVF.Results UG-PTA was successfully performed in all 48 cases.All patients completed more than 3 times effective HD,the technical and clinical success rate both of 100%(48/48).No serious adverse event occurred.In calcification group,the primary patency rate 3,6,9,12,24 and 36 months after UG-PTA was 75.89%,37.95%,37.95%,27.10%,14.46%and 0,and the secondary patency rate was 95.24%,95.24%,95.24%,89.95%,83.03%and 83.03%,respectively,while in non-calcification group the primary patency rate was 92.31%,73.08%,57.69%,53.85%,36.15%and 36.15%,and the secondary patency rate was 100%,100%,100%,100%,95.24%and 95.24%,respectively.After UG-PTA,the primary patency rate in calcification group was lower than that in non-calcification group(P＜0.05),but there was no significant difference of the secondary patency rate between groups(P＞0.05).Conclusion Calcification was a risk factor for primary patency rate of AVF after UG-PTA for stenosis,but had no significant impact on the secondary patency rate.