China ; Dentistry ; manpower ; Education, Dental ; Societies, Dental

China ; Education, Dental ; organization & administration ; Humans ; Oral Medicine ; education

China ; Education, Dental ; Oral Medicine ; education

China ; Cleft Lip ; epidemiology ; Cleft Palate ; epidemiology ; Dentist-Patient Relations ; Health Services Needs and Demand ; History, 20th Century ; History, Ancient ; History, Medieval ; Humans ; Malocclusion ; epidemiology ; Mouth Neoplasms ; epidemiology ; Prevalence ; Surgery, Oral ; education ; history ; organization & administration ; trends

China ; Oral Medicine

BACKGROUND:Medical risks are al unsafe events or that damage to the patient during medical services. Present medical risk management is mainly qualitative experience, and lacks of regular failure analysis and risk assessment for established medical treatment.
OBJECTIVE:To construct models of medical process failure analysis and risk assessment, find possible risks during medical treatment, and propose effective measures to eliminate or decrease above risks.
METHODS:Failure mode and effects analysis during reliability engineering were used in production. That was, risk assessment was conducted in the possible technical failure modes, causes and al impacts on the product during each process. Improvement measures were made for weak link during the process. The risk could reach an acceptable level. In accordance with failure mode and effects analysis during production, the procedure of medical process failure analysis and risk assessment could be made to analyze the potential failures during medical treatment. Moreover, the improvement measures were proposed for weak link with high risks so as to prevent the occurrence of risk of significant adverse effects on patients.
RESULTS AND CONCLUSION:The methods and basic procedures of medical process failure analysis and risk assessment were established by using the experience of failure mode and effects analysis. Taking the rescue process of myocardial infarction in the emergency of a hospital as an example, the analysis of failures, reasons and impacts was performed taking“chewing 300 mg aspirin”in the rescue steps as a key. The improvement measures and suggestions were proposed for unacceptable failures and reasons. Seen from the analysis results, proposed improvement measures and suggestions can obviously decrease the risks of failures caused by this step to patients. Therefore, the application of failure mode and effects analysis in medical treatment has a strong practical value.

Objective:To evaluate the clinical efficacy of combination of Beyond cold light whitening and fluoride-removing material bleaching system for treatment of dental fluorosis. Methods: Seventy-five patients with light, medium and heavy dental fluorosis were randomly divided into three groups. Twenty-five patients with 150 dental fluorosis from the experiment group were treated with Beyond cold light bleaching combined with fluoride-removing material;Twenty-five patients with 148 dental fluorosis from the control group one were treated with Beyond cold light bleaching. Twenty-five patients with 148 dental fluorosis from the control group two were treated with fluoride-removing material. The changes of teeth color were evaluated by Vita shade guide matching after treatment. Results: All of the light dental fluorosis in three groups had good lightening efficacy and 100% bleaching efficacy. The Shade value improvement and overall efficacy of observer group were better than the control groups for the medium and heavy fluorosis(P<0.05). Conclusion: Beyond cold light whitening combined with fluoride-removing material in bleaching is a good method for dental fluorosis bleaching.

Breast cancer is a kind of hormone-dependent tumor,the high level of estrogens is an impor-tant risk factor of breast cancer.There is evidence that estrogens through estrogen receptor (ER) signaling pathways and estrogen metabolic products participate in the development and progression of breast cancer.Recentally,studies demonstrated that SDF-1 and its receptor CXCR4 are involved in breast cancer.Estro-gens play an important role in the growth,proliferation and metastasis of breast eaneers through SDF-1/CX-CR4 signaling pathways.These findings may'provide a novel therapeutic target for breast cancer.

Objective:To investigate the effects of indicated concentrations VEGF and DEX on MMP-9 expression and motility of Tca-8113 cell. Methods:Immunohistochemistry and RT-PCR methods were used to detect protein and mRNA changes of MMP-9 in tongue squamous cell with VEGF and DEX treatment. Cell motility was also observed with Transwell incubation.Results:The level of protein and mRNA of MMP-9 as well as cell motility increased with indicated concentrations VEGF(1,5,10 ng/ml) in a dose dependent way(P

OBJECTIVE:To establish the quality standard of Liuwei dihuang pill (concentrated pill). METHODS:Radix Rehmanniae Preparata,Dioscorea opposita,Poria cocos and Alisma orientalis in Liuwei dihuang pill (concentrated pill) were identified by TLC and the contents of paeonolum and loganin were determined by HPLC.RESULTS:The TLC spots were clear and well-separated yet free of interference of negative sample.The linear ranges of paeonolum and laganin were 0.100 6～1.006 ?g (r=0.999 9) and 0.309 6～2.322 ?g(r=0.999 6),respectively,and their recovery rates were 98.2%(RSD=2.3%,n=6) and 95.3%(RSD=0.42%,n=6),respectively.CONCLUSION:The established standard is applicable for the quality control of Liuwei dihuang pill.