1.Cell-based therapy for the treatment of focal articular cartilage lesions: a review of six years of studies in a Malaysian University Medical Centre
Journal of University of Malaya Medical Centre 2014;17(2):1-11
Autologous chondrocyte implantation (ACI) is a significant technique that has gained widespread use for the
treatment of focal articular cartilage damage. Since its inception in 2004, the Tissue Engineering Group (TEG)
of the Faculty of Medicine, University Malaya has been dedicated to carrying out extensive research on this
cell-based therapy. The objective of this report, comprising one clinical case report, six animal studies and
one laboratory study, is to summarise and discuss TEG’s key findings. On the whole, we observed that the
ACI technique was effective in regenerating hyaline-like cartilage in treated defects. Autologous chondrocytes
and mesenchymal stem cells (MSC) were found to produce comparable tissue repair irrespective of the state
of MSC differentiation, and the use of alginate-based scaffolding and oral pharmacotherapy (Glucosamine
and Chondroitin Sulphate) was shown to enhance ACI-led tissue repair. ACI is suggested to be an efficient
therapeutic option for the treatment of articular cartilage defects of the knee.
Cartilage, Articular
2.A modified Blatt dorsal capsulodesis in the treatment of dynamic scapholunate instability.
Lynn Azura ; T Sara Ahmad ; T Kamarul
The Medical journal of Malaysia 2006;61 Suppl B():51-4
We report a case of scapholunate dissociation which was initially missed and presented late. A modification of Blatt dorsal capsulodesis performed using dorsal intercarpal ligament (DICL) and extra tunnel appears not only to add to dorsal stability but also address the volar problem as well. This modification may be a better alternative to the current technique of using a single flap.
therapeutic aspects
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Assault by stabbing
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Ligaments
3.Autologous chondrocyte implantation for knee focal cartilage defects: 3 years' follow-up at the University Malaya Medical Centre.
Abbas Aa ; Mohamad Ja ; Lydia Al ; Selvaratnam L ; Razif A ; Ab-Rahim S ; kavitha G ; Shilpa Pn ; Kamarul T
Journal of University of Malaya Medical Centre 2014;17(1):8-13
Autologous chondrocyte implantation (ACI) is a widely accepted procedure for the treatment of large, fullthickness
chondral defects involving various joints, but its use in developing countries is limited because of high
cost and failure rates due to limited resources and support systems. Five patients (age <45 years) with focal
cartilage defects received ACI at University of Malaya from 2006 to 2007 and followed up for 36 months. The
average presubjective Knee Evaluation Forms (IKDC) improved from 38.44±6.29 to 25.6±8.04 postoperatively,
the Oxford Knee Score (OKS) went from 25.6±8.04 to 13.96±1.63 and the American Knee Society Score (AKSS)
improved from 80±14.33 to 92.96±5.82 post-operatively. Thus improvements were seen in the IKDC and
AKSS score but not in the OKS. Magnetic resonance images showed the presence of cartilage tissue filling in
the lateral and medial patellar facet and medial femoral condyle in three patients. Failures were seen in two
patients, both with patellar defects and over the age of 36 years. Treatment with autologous chondrocyte
implantation for focal cartilage defect in lateral and medial patellar facet and medial femoral condyle showed
early improvement which was maintained at 3 yrs follow-up. ACI provided satisfactory outcome in focal cartilage
defects involving the femoral condyle.
Chondrocytes
8.COVID-19 in Singapore and Malaysia: Rising to the Challenges of Orthopaedic Practice in an Evolving Pandemic
Tay K, FRSC Ed Orth ; Kamarul T, MS Orth ; Lok WY, FRCS Ed Orth ; Mansor M, M Anaes ; Li X, MRCOG ; Wong J, FANZCA ; Saw A, FRCS Ed
Malaysian Orthopaedic Journal 2020;14(No.2):7-16
With the increasing number of COVID-19 cases and related deaths worldwide, we decided to share the development of this condition in Singapore and Malaysia. First few cases were diagnosed in the two countries at the end of January 2020, and the numbers have surged to thousands by end of March 2020. We will focus on strategies adopted by the government and also the Orthopaedic community of the two countries up till the beginning of April 2020. We hope that by sharing of relevant information and knowledge on how we are managing the COVID-19 condition, we can help other communities, and health care workers to more effectively overcome this pandemic.
9.An Engineered Novel Spatially Controlled Collagen Density Gradient Biomaterial For Soft Tissue Surgery
Vythilingam G ; Mohan S ; HM Larsson ; K Pinnagoda ; E Vardar ; EM Engelhardt ; CR Thambidorai ; Kamarul T ; JA Hubbell ; P Frey
Malaysian Orthopaedic Journal 2018;12(Supplement A):236-