1.Detection of Mycoplasma and Analysis of Drug Sensitivity in 3280 Patients with Nongonococcal Urethritis
Chinese Journal of Nosocomiology 2006;0(02):-
OBJECTIVE To understand the situation of Mycoplasma infection and drug sensitivity in the patients of nongonococcal urethritis(NGU) in area of Yuebei. METHODS Totally 3 280 specimens in the patients of NGU were collected,cultured and tested for drug sensitivity. RESULTS From them there were 1 221 patients who had Mycoplasma(37.22%).The simple infection of Ureaplasma urealyticun(Uu) was 922 cases(28.11%) and Mycoplasma(Mh) 91 cases(2.77%),respectively.The mixed was 208 cases(6.34%).The result of drug sensitivity showed that sensitivity of Mycoplasma to josamycin was the highest,then was to levofloxacin(Cravit) and sparfloxacin.Ciprofloxacin was with the highest drug resistance,then were erythromycin and doxycycline. CONCLUSIONS Mycoplasma have high drug resistance to ciprofloxacin,erythromycin and doxycycline.The resistance rate to minocycline and clarithromycin is in a rising tendency.The antibiotics should be used reasonably to reduce the development of drug-resistant strains.
2.The risk factors analysis of complications of 364 cases in treatment of radical esophagectomy
Xiwen WANG ; Kaiming REN ; Haijun LIU
Journal of Clinical Surgery 2017;25(2):135-138
Objective To study the risk factors of complications of 364 cases in treatment of rad-ical esophagectomy.Methods 364 patients underwent two or three-incision radical esophagectomy and the clinic data were retrospectively analyzed.After review of the reference,ten factors were regarded as the potential risk factors of postoperative complications,then univariate and multivariate analyses were per-formed.Results In 364 patients,66 patients had complications of this research field within postoperative 6 months.By univariate analysis,preoperative nutritional risk score、T-staging、preoperative complications、operation time、operation experience、anastomotic position、anastomotic extra manual suturing were deter-mined as influence factors.By multivariate analysis,preoperative nutritional risk score≥3、T-staging score≥3、preoperative complications、operation time≥240 min、cervical anastomosis were determined as risk factors,anastomotic extra manual suturing was determined as a protective factor.Conclusion The risk factors of the complications after radical esophagectomy are preoperative nutritional risk score≥3、T-stag-ing score≥3、preoperative complications、operation time≥240 min、cervical anastomosis;and the protective factor is anastomotic extra manual suturing.Paying attention and controling these risk factors may reduce the occurrence of postoperative complications.
3.Effect of Evaluation Method on Quality of Prescription
Taoran ZHOU ; Deqiu ZHU ; Kaiming WANG
China Pharmacy 2007;0(34):-
OBJECTIVE:To investigate the effect of evaluation method on management of prescription. METHODS:A total of 24 000 prescriptions of 12 months were evaluated with both method 1 devised by our hospital and method 2 specified in ordinance of Management of prescription. The administration department intervened physicians’ prescription behaviors according to the evaluation results. The change of data in method 1 was compared with that in method 2. RESULTS: In method 1,the problems of usage and dosage increased a little while other irrational problems lessened largely. In method 2,the average amount of drug categories reduced a little while the other data increased a little. CONCLUSION: The effect of evaluation and intervention in method 1 are superior to those in method 2.
4.Clinical study on the metastatic patterns of mediastinal lymph node in non-small-cell lung cancer
Qingmu ZHONG ; Zilong CHEN ; Kaiming WANG
Cancer Research and Clinic 2013;25(7):469-471,474
Objective To explore the reasonable clinical target volumes by analyzing the characteristic of mediastinal lymph node metastases in non-small-cell lung cacer (NSCLC).Methods 291 NSCLC patients was performed pre-therapy CT scans,and the incidence of mediastinal lymph node metastases was analysed.Results Among the 152 patients with right lung NSCLC,the incidence of involvement of the ipsilateral supraclavicular lymph nodes was 15.8 % (24/152),and the incidence of involvement of the contralateral lymph nodes was 6.6 % (10/152).The highest incidence of mediastinal nodal involvement occurred in the ipsilateral hilar nodes (59.2 %),followed by area 4R (56.6 %),area 1-2R (36.2 %),area 7 (33.6 %),area 4L(20.4 %),area 10-11L (5.9 %),area 6 (3.9 %),area 5 (2.0 %),area 1-2L (2.0 %),respectively.Among the 139 patients left lung NSCLC,the incidence of involvement of the ipsilateral supraclavicular lymph nodes was 15.8 % (23/139),and the incidence of involvement of the contralateral lymph nodes was 5.8 % (8/139).The highest incidence of mediastinal nodal involvement occurred also in the ipsilateral hilar nodes (54.0 %),followed by area 7 (33.8 %),area 4R (26.6 %),area 4L (24.5 %),area 1-2R (15.8 %),area 5 (10.8 %),area 6 (9.4 %),area 1-2L (5.8 %),area 10-11R (5.0 %) respectively.Conclusion The right side primaries or left side primaries of NSCLC have different high risk lymph node areas for metastasis,and selective irradiation to these lymph node areas maybe increase the tumor control rate and reduce the recurrence rate.
5.The differences among the pass rate of intensity modulated radiation therapy planning in different tumors
Yong WANG ; Junping LI ; Lingling ZHANG ; Kaiming WANG ; Wenjie CAI
Chinese Journal of Radiation Oncology 2017;26(1):50-52
Objective To investigate the difference in the pass rate of intensity?modulated radiation therapy ( IMRT) planning in patients with different tumors and its value in determining pass rate thresholds. Methods A total of 35 verified IMRT plans for each of esophageal cancer, nasopharyngeal carcinoma, breast cancer, cervical cancer, and lung cancer were selected consecutively, and a one?way analysis of variance was used to investigate the difference in pass rate. A single pass rate threshold was used to test all IMRT plans, and the pass rate thresholds of IMRT plans for different tumors were calculated based on normal distribution law. Results There was a significant difference in the means between the 5 groups of data ( F=35. 83, P<0. 01) , and there was also a significant difference between any two groups ( P=0. 000) . There were statistically significant differences between nasopharyngeal carcinoma group and other four groups ( P=0. 000) . The difference was not only significant between the breast cancer group and the esophageal cancer group ( P=0. 001) , but also between the breast cancer group and the lung cancer group ( P=0. 033) . The calculated results of each threshold were 93. 37%, 89. 34%, 97. 68%, 95. 99%, and 95. 42%, respectively. Conclusions Different thresholds should be used for IMRT plans for different tumors, and the normal distribution law can be used to calculate the threshold.
6.OsCOI1, a Putative COI1 in Rice, Show MeJA and ABA Dependent Expression
Tingzhang HU ; Weiping WANG ; Kaiming CAO ; Xiping WANG
Progress in Biochemistry and Biophysics 2006;33(4):388-393
A novel gene, which was a homologue of Arabidopsis COI1 was isolated from rice (Oryza sativa L.) by RT-PCR and designated as OsCOI1. It encoded a protein of 595 amino acids. The similar F-box motif and 16 leucine-rich repeats were found in the deduced protein OsCOI1. OsCOI1 and COI1 showed high homology (74%) at amino acid level. Semi-quantitative RT-PCR and Northern blot analysis demonstrated that the expression of OsCOI1 in rice varied obviously after treatment with MeJA and ABA but was not affected by SA and ET, suggesting that the specific function of OsCOI1 in JA signal pathway and related ABA pathway.
7.The application of diffusion weighted imaging in the cervical spondylotic myelopathy with 3.0T MRI
Kaiming CAO ; Nanxin HAO ; Yibin WANG ; Genlin ZONG ; Yushan DU
Journal of Practical Radiology 2014;(6):918-922
Objective To explore the value of diffusion weighted imaging (DWI)as a quantitative analysis tool for chronic cervical spondylotic myelopathy (CSM)with 3.0T MRI.Methods Cervical routine MR T2-weighted imaging(T2 WI)and diffusion weighted imaging were performed in 38 patients with cervical spondylotic myelopathy (CSM group)and 20 healthy volunteers (control group),and sagittal image of apparent diffusion coefficient (ADC)was reconstructed.The number of high T2 signal of the spinal cord were calculated in both healthy volunteers and CSM patients.The ADC values of CSM groups were measured in C3,T1 -C2 level and the compression or abnormal signal parts of the spinal cord;the control group measured C3、C4-C6 and T1 -T2 level in the spinal cord.Results There were 3 cases,1 case,6 cases and 8 cases high T2 signals in CSM patients from Ⅰ to Ⅳ levels,while there were 2 cases show high T2 signals in control group,respectively.The mean ADC values of the compression part were gradual-ly increased in CSM group from Ⅰ to Ⅳ level.There were significant differences of the mean ADC values of compression part be-tween the control group,CSMⅠ-Ⅱ level and the CSM Ⅳ level.Conclusion From our study,the change of ADC value of spine cord occured earlier than the change of signal in CSM patients.Therefore,the ADC value of spine cord might reflect the degree of spinal cord compression from CSM patients.
8.Delayed effect of isoflurane on hippocampal proteome after anesthesia in adult and aged rats
Kaiming DUAN ; Wen OUYANG ; Manhong CHEN ; Yuefeng XIA ; Saiying WANG
Journal of Central South University(Medical Sciences) 2009;34(7):589-594
Objective To investigate the delayed alteration of hippocampus proteome after an-esthesia with isoflurane in aduh and aged rats. Methods Ten 8-month-old SD rats were randomly divided into group Caduh and group Iadult (5 in each group) , and another ten 22-month-old SD rats were randomly divided into group Caged and group Iaged (5 in each group). The rats in group Iadult and group Iaged received 2 h anesthesia with 1.2 % isoflurane. The rats in group Cadult and group Caged inhaled 40% oxygen for contrast. The hippocampal proteome of each rat was measured by 2-dimensional gel electrophoresis and mass spectrometry. Results The vital signs of the rats in group Iadult and group Iaged were stable. There were 878±34 protein spots in group Cadult, 864±49 protein spots in group Iadult, 834±47 in group Caged, and 819±24 in group Iaged. There were 12 (4/8)different protein spots between group Iadult and group Cadult. There were 11 (3/8) different protein spots between group Iaged and group Caged. All of the protein spots were identified by MALDI-TOF-MS. Most of the different proteins were related to metabolism, anti-oxidation, and signal conditioning of synapse. Conclusion Isoflurane may cause the alteration of hippocampal pro-teome in rats, which is age-related.
9.Percutaneous kyphoplasty for treatment of osteoporotic vertebral body compression fractures in the elderly
Zhiyong YANG ; Kaiming WANG ; Bingjun LEI ; Qing ZHANG
Chinese Journal of Geriatrics 2017;36(7):788-790
Objectives To study the clinical effects of percutaneous kyphoplasty on senile osteoporotic vertebral body compression fractures.Methods The 87 elderly patients with osteoporotic vertebral body compression fractures were randomly grouped into control group (n=42) treated with percutaneous vertebroplasty and observation group (n=45) treated with percutaneous kyphoplasty in our hospital from June 2013-March 2016.And the clinical curative effect before and after treatment was compared and analyzed.Results The visual analog scale (VAS) pain score in observation group versus control group was (8.49±2.86) vs.(8.56±2.98),(t=0.11,P>0.05) before treatment,and[(2.58±1.34) vs.(3.34±2.01),t=2.09,P< 0.05],[(2.06±0.97) vs (3.87±1.96),t=5.51,P<0.05]and[(1.09±0.89) vs (2.37±1.29)],t=5.42,P<0.05]at 1 week,4 weeks,and 12 weeks after treatment respectively,showing statistically significant improvement after treatment.The data of kyphosis angle by using Cobb angle,Oswestry lumbar dysfunction index (ODI),mean time of postoperative ambulation,and mean postoperative hospital stay were similar to that of the visual analog scale (VAS) pain score,showing statistically significant improvement after treatment (all P<0.05).The incidence[cases (%)]of bone cement leakage was lower in observation group[3(6.7)]than in control[9(21.4)](χ2=3.98,P<0.05).Conclusions Clinical treatment effects of percutaneous kyphoplasty on the elderly patients with osteoporotic vertebral body compression fractures are superior to that of percutaneous vertebroplasty.Percutaneous kyphoplasty can effectively relieve pain,and improve body function disorders and the quality of life.
10.Changes of cerebral gray matter pre- and post-treatment in patients with schizophrenia
Qiong XIANG ; Yingchan WANG ; Dianming ZHU ; Kaiming ZHUO ; Zheng WANG ; Yifeng XU ; Dengtang LIU
Journal of Shanghai Jiaotong University(Medical Science) 2017;37(2):203-206
Objective · To observe the changes of cerebral gray matter pre- and post-treatment with short term drugs in patients with schizophrenia. Methods · T1-weighted brain MRIs were obtained on a 3T scanner in 21 controls and 27 subjects with schizophrenia who were not given antipsychotic medication. The controls and 21 schizophrenia patients received the second scan after 8 weeks of antipsychotic treatment. Voxel-based morphometry (VBM) were used to investigate the differences in gray matter (GM), mainly about the regional GM volumes. Results · GM volumes were significantly smaller in the patient group than those of healthy controls in left cerebellum posterior lobe , left and right parahippocampalgyrus, left middle temporal gyrus(P=0.000, voxels>50). GM volumes extensively decreased after 8 weeks of antipsychotic-treatment compared with pre-treatment in the superior, middle, and inferior temporal gyri, superior,middle and inferior frontal gyri, parahippocampa gyri, cingulate gyri, right supramarginal gyrus, right cerebellum posterior lobe, and right lingual gyrus(P=0.000, voxels>50). Conclusion · Short term antipsychotic treatment (8 weeks) may have adverse effects on the gray matter of patients with acute schizophrenia by reducing the volume of gray matter.