1.A case of neurofibroma of vocal fold.
Kai CHEN ; Huang LIN ; Xue-fen LI
Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2011;46(5):428-429
Adult
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Humans
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Laryngeal Neoplasms
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Male
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Neurofibroma
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Vocal Cords
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pathology
2.Treatment of scapular fracture through a posterior approach
Kai YANG ; Tienan QU ; Qingpei XUE
Orthopedic Journal of China 2006;0(22):-
[Objective]To investigate the effect of surgical treatment of scapular fractures through posterior approach.[Method]From May 2000 to November 2007,14 patients(10 females,4 males;mean age 34.6 years)with scapular fractures were treated by open reduction and internal fixation through a posterior approach.Eight patients were injurred in traffic accidents,3 due to falling,2 by direct violence and 1 due to cut.There were eleven patients with close fractures and 3 with open fractures.According to Hardegger classification system,there were 8 cases of scapular body fracture,9 of scapular spine fracture,6 of scapular acromion,10 of scapular neck fracture,6 of glenoid rim fracture and 4 of glenoid fossa fracture.[Result]Fourteen patients were followed up,with a mean follow up time of 18 months.According to Rowe score system,10 patients showed an excellent result,2 showed a good result,the other two showed a fair result.[Conclusion]The posterior approach for fixing scapular fractures has advantages of wide exposure,safety,easy operation,and reliable effect.It is a choice of operation for most types of scapular fractures,especially for scapular body fracture,spina scapular fracture and scapular multiposition fracture.
3.HISTOCHEMICAL OBSERVATIONS ON THE RENAL TUBULO-TOXICITY OF GOSSYPOL
Kai CHENG ; Xiaomei CHEN ; Shepu XUE
Acta Anatomica Sinica 1989;0(S1):-
Gossypol has been shown to cause a side effect hypokalemia. This study was designed to evalulated the possible role of gossypol in relation to renal potassium loss by using histochemical method for comparative analysis of gossypol and gentamicin, a well known tubulo-toxic agent, as positive control with respect to nephrotoxic demage in rats and guinea pigs. The results indicated that gossypol had obvious effect on reabsorption function by inducing transitional decrease of membrane enzymes activities of renal tubular cells but had no effect as comparable with gentamicin to cause structureal damage of tubular cells.
4.Case of bilateral diaphragm paralysis.
Kai-xue JIA ; Ying-hui WANG ; Cong-huo TIAN
Chinese Acupuncture & Moxibustion 2011;31(6):565-566
Acupuncture Therapy
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Diaphragm
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pathology
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Humans
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Male
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Middle Aged
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Respiratory Paralysis
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pathology
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therapy
6.Expression and clinical significance of PI3K, Akt and E-cadherin in thyroid papillary carcinomas
Dong XUE ; Li KONG ; Kai ZUO ; Xinjun LI ; Tongjun ZHANG
Journal of Chinese Physician 2015;(3):357-360
Objective To investigate the expressions of phosphatidylinositol 3-kinase (PI3K), Akt and E-cadherin and their clinical significance in thyroid papillary carcinomas.Methods Expressions of PI3K, Akt, and E-cadherin were detected in 62 cases of thyroid papillary carcinomas,30 cases of thyroid goiter and 30 cases of normal thyroid by immunohistochemistry (EnVison),and simultaneously compared with age, sex, tumor size, clinical tumor node metastasis( TNM) stages, and lymph node metastasis in thy-roid papillary carcinomas.Results The expression rate of PI3K, Akt, and E-cadherin was 74.2%(46/62), 66.1%(41/62), 16.1%(10/62),respectively.Expressions of three proteins in thyroid papillary carcinomas were significantly different from those in thyroid goiter and normal thyroid tissues ( P <0.05). The lower positive rates of PI3K and Akt proteins were obtained in the group of stageⅠ~Ⅱthan that in the group of stageⅢ~Ⅳ(χ2 =4.976, P =0.026;χ2 =6.233, P =0.013).Higher positive rates of PI3K and Akt proteins were obtained in the group of lymph-node metastasis than that in group of non-lymph-node metastasis (χ2 =6.675, P =0.010;χ2 =7.511, P =0.006).Higher positive rate of E-cadherin protein was obtained in the group of stage Ⅰ~Ⅱ than that in the group of stage Ⅲ ~Ⅳ (χ2 =6.558, P =0.010 ) .Higher positive rate of E-cadherin proteins was obtained in the group of non-lymph-node metastasis than that in the group of lymph node metastasis(χ2 =5.678, P =0.017).There was significant positive correlation between expressions of PI3K and Akt through Spearman correlation analysis ( r =0.423, P <0.05).PI3K was negatively correlated with E-cadherin with Spearman correlation analysis ( r =-0.527, P <0.05).Akt was also negatively correlated with E-cadherin ( r =-0.417, P <0.05).Conclusions PI3K/Akt pathway might regulate thyroid papillary carcinoma cells proliferation, invasion and metastasis.
7.The relationship between microRNAs and colorectal cancer radiosensitivity and underlying mechanism
Yuequan ZHU ; Kai XIONG ; Jie WEN ; Junjie WANG ; Lixiang XUE
Chinese Journal of Radiological Medicine and Protection 2016;36(10):780-784
Colorectal cancer is currently the third most common cancer worldwide,and there are still half of the patients undergoing recurrence and metastasis after surgical treatment,so it is necessary for colorectal cancer patients to receive radiation therapy routinely.Due to the side effects brought by radiotherapy,it is of great importance to solve how to minimize the radiation dose in radiation therapy and improve radiation sensitivity.In recent years,people discovered that microRNAs can not only be involved in the origins of colorectal cancer and progress,but also play a increasingly important role in cancer radiosensitivity.MicroRNAs can regulate tumor radiosensitivity by influencing tumor microenvironment and function on target genes.DNA damage response caused by radiation includes the activation of ATM,histone modification and chromatin remodeling,cell cycle arrest,damage repair and apoptosis.microRNAs can regulate tumor radiosensitivity through above processes.This review focuses on the mechanism of microRNAs in affecting DNA damage repair and prospects the future of microRNAs in influencing the sensitivity of cancer radiotherapy in clinical application.
8.Expression of P450 aromatase in endometrial carcinoma
Xue-Mei ZOU ; Kai WU ; Zhu-Hong XU ;
Cancer Research and Clinic 1997;0(03):-
0.05).Immunohistochemical staining for intratumoral aromatase in endometrial cancer was positive,21(42 %)in stromal cells.The expression of P450 aromatase in stromal cells correlated positively with advanced surgical stage and histologic grade,indepedent on muscular invasion and lymph node metastasis.Conclusion Aromatase P450 play an important function in establishment and devel- opment of the endometrioid endometrial cancer.The expression of P450 aromatase in intratumoral stromal cells correlated positively with the development and prognosis of endometrioid endometrial cancer.
9.Analysis of 326 cases of transabdominal radical operation for cardial carcinoma
Xue-Yi DANG ; Kai JIA ; Jian-Hong DONG ;
Cancer Research and Clinic 2001;0(04):-
Objective To evaluate the safety of a surgical appwach for transabdominal cardial carci- noma.Methods We retrospectively analyzed 326 patients undergoing transabdominal esophagastrostomy or esophagojejunostomy from 1998 to 2006 via the EEA(end-to-end anastomosis)stapler.Results By the surgi- cal approach for transabdominal cardial carcinoma,the average length of reseete esophagus above the carci- noma was about 6~8 cm realized the low average of remnant carcinoma at the margin and operation mortality and anastomotic leakage,which was lower than those in the thoraeotomy appmaeh significantly.Conclusion The transabdominal approach makes a clear operative field in posterio-inferior mediastinum,it is beneficial for radical resection of eardial carcinoma and intramediastinal esophagogastric or esophagojejunal mechanical anastomosis,and it fits to the old,the weakening and with the disease of heart and lung.
10.Clinical study of combination therapy of tamsulosin and solifenacin for benign prostatic hyperplasia with overactive bladder
Chen JIANG ; Kai SUN ; Yonghui CHENG ; Wei XUE ; Yiran HUANG
Chinese Journal of Urology 2011;32(9):639-642
ObjectiveTo evaluate the efficacy and safety of combination therapy of tamsulosin and solifenacin for benign prostatic hyperplasia ( BPH ) with overactive bladder ( OAB ).Methods82 patients with OAB and coexisting BPH were randomly divided into tamsulosin group ( n = 38 ) and combination group ( n = 44). The ages were from 50 to 75 y ( averaged, 56.8 ± 8.6). Inclusion criteria: the mean frequency of micturition ≥8 times per day, the frequency of nocturia ≥2 times per day, voiding volume <200 ml each time; for the overactive bladder symptom score ( OA BSS), the 3 rd score > 2, total score > 3. The tamsulosin group accepted tamsulosin 0.2 mg once daily, the combination group accepted tansulouxin 0.2 mg and solifenacin 0.2 mg once daily. Both groups were maintained the corresponding therapy for 12 weeks.The international prostate symptom score (IPSS), Qmax, residual urine volume, OAB score and adverse reactions were recorded.ResultsThe values of IPSS ( 19.5 ±2.2 vs 15.6 ±2.4, P =0.027), the voiding symptom score ( 15.6 ± 2.4 vs 3.4 ± 1. 7, P = 0. 022) and Qmax ( 13.7 ± 3.8 vs 16.6 ± 4.1, P = 0. 034 )improved significantly after treatment in tamsulosin group ( P < 0. 05 ). The values of IPSS ( 19.7 ± 2.3 vs 9.7 ± 3.0, P <0. 001), the storage symptom score (13.8 ± 1.9 vs 5.6 ± 1.6, P <0. 001 ), OABSS (10.3 ±1.8 vs 5.3 ±1.3, P <0.001) and Qmax(14.1 ±4.1 vs 17.2 ±3.5, P=0.027) also improved significantly after treatment in combination group ( P < 0. 05 ). The values of IPSS ( 9.7 ± 3.0 vs 15.6 ±2.4, P < 0.001 ), the storage symptom score (5.6 ± 1.6 vs 12.0 ± 1.6, P < 0.001 ) and OABSS ( 5.3 ±1.3 vs 9.7 ± 2.7, P < 0. 001 ) improved significantly in combination group than those in tamsulosin group ( P <0.001 ). There were no difference between two groups in values of the voiding symptom score, Qmax and residual urine volume ( P > 0.05 ). The incidences of adverse reactions in tamsulosin group and combination group were 7.9% (3/38) and 20.5% (9/44) without significant difference. There was no acute urinary retention in both groups.ConclusionsIt is effective and safe for patients with BPH and OAB to accept combination therapy of tamsulosin and solifenacin.