1.Effectiveness of Different SSRI Antidepressants in Combination with CBT for Short-term Management of Panic Disorder
Malaysian Journal of Medicine and Health Sciences 2007;3(2):37-43
Objective: This paper reports the result of an analysis of data of brief therapy for out-patients with panic disorder reffered by physicians in a busy specialist hospital in Kuala Lumpur. Methods: The patients were randomly assigned into different groups of SSRI (Specific Serotonin Reuptake Inhibitor) antidepressants i.e. escitalopram, setraline, or fluoxetine. All patients received cognitive behaviour therapy (CBT). The therapy was aimed for a maximum of twelve sessions. There were 33 patients in the escitalopram group, 31 patients in the setraline group, and 31 patients in the fluoxetine group. Results: the result shows that all the groups were similar in the severity and scores for pre-treatment but for post-treatment, there were significant differences among them. Conclusion: All groups showed significant improvements in all modalities of measurements. However, the escitalopram and setraline groups showed faster overall improvement compared to the fluoxetine group.
2.The Socio-Demographic and Clinical Factors Associated with Quality of Life among Patients with Haematological Cancer in a Large Government Hospital in Malaysia
Das Priscilla ; Awang Hamidin ; Md Zain Azhar ; Kon Noorjan ; Md Said Salmiah ; Khalid Bahariah
Malaysian Journal of Medical Sciences 2011;18(3):49-56
Background: The paper examined the quality of life of haematological cancer patients
according to their socio-demographic profiles and clinical diagnoses.
Methods: This cross-sectional study was conducted at the tertiary referral centre of Ampang
Hospital, Kuala Lumpur, involving 105 patients. The European Organisation for Research and
Treatment of Cancer Quality of Life (EORTC QLQ-C30) questionnaire was used to measure their
quality of life.
Results: The study involved patients diagnosed with all types of haematological cancer,
including non-Hodgkin lymphoma (NHL), acute myelogenous leukaemia (AML), acute lymphoblastic
leukaemia (ALL), Hodgkin lymphoma (HL), and multiple myeloma (MM), with a response rate of
83.3%. The patients with ALL, HL, without NHL, and without MM were younger than other patients.
There were significant differences in quality of life scores in different socio-demographic groups
and types of cancer diagnosis. The global quality of life of the female patients was much better than
that of the male patients. Patients who were 40 years old or younger had a better global quality
of life and physical functioning, as well as fewer symptoms of constipation, nausea, and vomiting.
Employed patients were in less pain but showed greater impairments of cognitive function than
did unemployed patients. Patients who earned a monthly wage of RM1000 or less had reduced
physical function, more symptoms of pain, and more financial difficulties compared with patients
who earned more. Patients with AML tended to have better physical functioning than did patients
with MM, whose physical functioning was impaired. Comparatively, more symptoms of dyspnoea
were found in ALL and HL patients than in other types of lymphoma. Compared with other patients,
those with ALL had a greater loss of appetite, and other lymphoma patients had fewer symptoms of
pain. Patients with NHL had impaired role functioning and more constipation compared with other
patients. The results were all statistically significant (P < 0.05).
Conclusion: The quality of life of haematological cancer patients is affected by sociodemographic
factors and clinical diagnoses. Efforts should be made to improve the overall quality of
life of these patients.