Objective:To evaluate the knowledge and recognition of the influence factors of adverse drug reactions in medical staffs in Nanjing.Method:A structured questionnaire was used to collect information on ADR related knowledge in medical staffs in some selected hospitals in Nanjing.Result:972 valid questionnaires were obtained form 1200 selected subjects,and the response rate was 81.0%.The scores were significantly different in age groups,sex and different kinds of occupational medical workers.The mean levels of the scores were analyzed between different groups.The single factor analysis demonstrated that the different levels of hospitals,sex,knowledge and occupation were correlated with the recognition. The multiple factors logistic regression analysis demonstrated that the recognition of adverse drug reaction among medical staff in Nanjing was related with different levels of hospitals and different occupations.Conclusion:In order to enhance the recognition level,it is necessary to carry out both the long-term education and train about the specialized knowledge of ADR in basic hospitals and non-pharmacy medical staff.

Objective　To investigate the association betwee n the β3-adrenergic receptor gene (β3-AR) and obesity. Methods　147 patients with obesity and 106 controls were selected. Genotype of the β 3-AR was determined by polymerase chain reaction (PCR) and restriction fragme nt length polymorphism methods (RFLP). Body mass index (BMI) was detected. Results　The frequency of Arg64 allele of β3-AR gene in the obesit y g roup (20.3%) was significantly higher than those in the control group (10.2%) ( P=0.001) . The distribution of Trp64Arg and Arg64Arg genotype in the patient group (38.7% and 0.9%) were both higher than that in the control group (19.0% and 0.7%). In the female subj ects, the Trp64Arg mutation and frequency of Arg64 allele of the β3-AR gene in the obesity group(40.6% and 20.3%) were also higher than those in control (16 . 7% and 9.5%)(P<0.01). Conclusions　These results suggest th at the Trp64Arg mutation of the β3-adrenergic-receptor gene may be associat ed with increased body fat.

OBJECTIVETo study the relationship between the inheritable factor and environmental factors of type 2 diabetes mellitus in humans.

METHODSA case-control study based on 154 type 2 diabetes mellitus and 130 healthy controls was carried out in Jiangsu Province in 1997.

RESULTSThe age, family history of diabetes mellitus, hypertension history, high waist/hip ratio (WHR), high systolic blood pressure, huge fetus history, and the genotype of beta(3)-adrenergic receptor (beta(3)-AR) were the risk factors of type 2 diabetes mellitus; while occupational physical activity was protective factor of type 2 diabetes mellitus. The risk for diabetes mellitus distinctly increased while genetic factor and obesity, beta(3)-AR mutation were coexisting.

CONCLUSIONType 2 diabetes mellitus is caused by the effect of both genetic and environmental factors.

Aged ; Case-Control Studies ; China ; Diabetes Mellitus, Type 2 ; epidemiology ; etiology ; genetics ; Environment ; Female ; Humans ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Obesity ; Risk Factors