TLRs are pattern recognition receptors (PRRs) whose cytoplasmic signalling domain is similar to that of IL-1. The extracellular domain of TLRs serve as the binding site of pathogen associated molecular patterns. TLRs are found on both plasma and endosomal membranes and they mainly exert their function by activating genes which lead to production of inflammatory factors. The latest TLR to be discovered, TLR10 is a unique TLR which exhibit anti-inflammatory properties. TLR10 is found on the plasma membrane with other TLRs namely TLR1, TLR2, TLR4, TLR5 and TLR6. Studies have revealed that TLR10 is found on the same gene cluster with TLR1 and TLR6 and is also a coreceptor of TLR2. Up to date, TLR10 is the only TLR which exhibit anti-inflammatory property. Previously, TLR10 was thought to be an “orphan receptor” but much recent studies have identified ligands for TLR10. Currently there is no review article on TLR10 that has been published. In this narrative review, we are going to give an account of TLR10, its functions mainly as an anti-inflammatory PRR and its possible applications as a target in therapeutics.

Introduction: International students are exposed to multiple mental health crises due to social, environmental and culture shocks in foreign lands but it gets worse in presence of lifethreatening disease outbreak. This research was conducted to evaluate the homesickness, anxiety and depression among Pakistani international students in Indonesia during Covid-19 Outbreak. The Methodology conducted on 86 random students that are pursuing their studies in different public and private universities in Indonesia. The data were collected by distributing goggle forms via email and social media groups and the responses from the respondents were recorded and analysed statistically. Results: The study findings revealed that there is a correlation between Covid-19 pandemic and the development of various mental health crises where 33 students (38.37%) developed homesickness, 11 students (12.79%) developed anxiety and 2 students (2.33%) manifested low-grade depression. Homesickness was outstandingly observed in females (72.72%) whereas anxiety was highly reported in males (90.90%).The study findings demonstrated that there is a strong negative correlation between student financial statuses and the development of homesickness (r:-0.977, P:0.023) and anxiety (r:-0.944, P:0.056). Conclusion All in all, the fear to contract coronavirus, lockdowns, financial instability, death toll of citizens and medical professionals, run out of medical facilities and social media hoaxes are significant risk factors of mental health crisis among Pakistani international students in Indonesia.