1.Effects of laparoscopic versus open hepatectomy on liver function
Gang WANG ; Rong LIU ; Junyuan JIANG ; Suichong YANG ; Yong NIE ; Mai WENG ; Changgeng LI
Chinese Journal of General Surgery 1997;0(06):-
Objective To study the effects of laparoscopic and open hepatectomy(LH and OH) on liver function of patients,and to evaluate patients′ traumatic reaction after LH.Methods Forty patients scheduled to undergo hepatectomy were divided into LH group and OH group randomly in PLA General Hospital from Jun.2004 to Feb.2005.Data of pre-and post-operative liver function of the two groups were compared.Results Postoperative mean value of ALT,AST and LDH in LH group and OH group elevated quickly,and the postoperative mean value of these markers was significantly different compared to that of the preoperative value,and the mean value in OH was higher than that in LH.There was no significant difference between postoperative and preoperative level of ALP and ?-GT in both groups,but postoperative mean value of them in OH was higher than that in LH.There was no significant difference between the 2 groups in TBIL and DBIL level,but their postoperative mean value in OH was higher than that preoperatively.Conclusions The effects of LH on liver function in patients are less than those of OH.This finding suggests that patients′ traumatic reaction after LH is less than that after OH and this is beneficial for the reduction of hepatic failure after LH.
2. Tolerance and pharmacodynamics phase Ⅰ clinical trial study of chimeric anti-CD20 monoclonal antibody IBI301 in Chinese patients with CD20-positive non-Hodgkin’s lymphoma
Bo JIANG ; Junyuan QI ; Mingyuan SUN ; Zengjun LI ; Wei LIU ; Lijun LIU ; Fengkui ZHANG ; Lugui QIU
Chinese Journal of Hematology 2018;39(4):320-324
Objective:
To evaluate the tolerance and safety of a human-mouse chimeric anti-CD20 monoclonal antibody IBI301 in Chinese patients achieved objective response with CD20+ B-cell non-Hodgkin’s lymphoma (NHL).
Methods:
Nine patients with CD20+ B-cell NHL received dose-escalating IBI301 infusions (250 mg/m2,