C. Conclusion Adequate hemodilution can attenuate the lung injury induced by I/R. The protective effect is better if hemodilution is performed before I/R.

Objective To examine the white matter microstructure alternations in the patients with generalized anxiety disorder (GAD) with diffusion weighted imaging.Methods 19 patients with GAD and 20 matched healthy controls were assessed using apparent diffusion coefficient (ADC) and exponential apparent diffusion coefficient (eADC) in the regions of interests (ROIs) approach.The ROIs were the white matter of bilateral cingulate and bilateral hippocampus.Results Significantly increased ADC values were found in GAD patients (0.78±0.02,0.79±0.03) with respect to normal controls in the right and left anterior cingulate white matter.Significantly decreased eADC values were found in GAD patients (0.46±0.01,0.45±0.01) in the right and left anterior cingulate white matter.Conclusion Diffuse cingulate white matter alterations on DWI in GAD denote the disruption of white matter integrity.

This article described the background,concept,characteristic and objective of the research-based nursing,systematically introducing the main measures including management mechanism, nursing service,nursing staff training,and nursing scientific development.Other areas covered include innovation management mechanism,updating service philosophy,improving nursing staff training,and constructing scientific research platform.

This study was designed to investigate the correlation between autophagy and polarization of macrophages in atherosclerosis (AS) plaque in arteriosclerosis obliterans amputees. Femoral artery specimens from arteriosclerosis obliterans amputees were performed hematoxylin and eosin (HE) staining, oil red O and immunofluorescence staining to observe the morphology of atherosclerotic plaque, phenotype of macrophages and autophagy in plaque; using real-time quantitative RT-PCR technology to detect the mRNA level of M1 and M2 type markers in arterial tissue; to analyze polarized signal pathway and autophagy protein levels in macrophages by Western blotting. Arterial specimens staining showed obvious lipid deposition and obvious infiltration of amount of foam cells and inflammatory cells. Macrophages were mainly expression M1 type in percentage in fibrous plaque. Although both M1 and M2 macrophages were upregulated in atheromatous plaque, the increase was dominant in M2 type in percentage. The level of autophagy was significantly higher in the atheromatous plaque than that of fibrous plaque. The expression of tumor necrosis factor- α (TNF-α), monocyte chemotactic protein-1 (MCP-1), inducible nitric oxide synthase (iNOS), interleukin-6 (IL-6) and interleukin-12 (IL-12) mRNA was significantly higher in fibrous plaque than that of atheromatous plaque (P < 0.01 or 0.05), and arginase-1 (Arg-1), transforming growth factor-β (TGF-β), CD163 and interleukin-10 (IL-10) mRNA was significantly lower than that in atheromatous plaque (P < 0.01). The levels of p-STAT1 and NF-κB were significantly increased in fibrous plaque (P < 0.01), while p-STAT6 expression was significantly increased in atheromatous plaque (P < 0.01). The level of LC3-II was significantly higher in atheromatous plaque than that in fibrous plaque (P < 0.01). Macrophages in early atherosclerotic plaque were induced to M1 type through p-STAT1/NF-κB pathway and expressed moderate levels of autophagy; while macrophages in advanced plaques were induced to polarization of M2 type through p-STAT6 pathway. M2 macrophages expressed a higher level of autophagy than M1 macrophages.

A new adaptive pneumatic tourniquet was developed for limb operation and first-aid. The crucial hardware circuits of the adaptive pneumatic tourniquet were designed based on the microprocessor C8051F340 and blood pressure module CSN602, software was programmed and an experiment was carried out for verifying the system. Results showed that the prototype could measure accurately systolic blood pressure, heart rate and other relative parameters and the designed device could adjust tourniquet cuff's pressure through inflation and deflation according to systolic blood pressure and limb circumference. This designed system integrated the advantages of the adaptive pneumatic tourniquet, and could be used for controlling life-threatening extremity hemorrhage operation and maintaining a bloodless opeation field.
Equipment Design ; Humans ; Microcomputers ; Tourniquets

Objective To establish the regression equation of blood pressure in population based on the pulse wave transit time (PWTT) and verify its accuracy. Methods A convenient sampling method was used to collect gender, age, arm circumference, arm length, PWTT, history of hypertension, and body height, etc. of 4 121 outpatients' information from the Hainan Branch of Chinese PLA General Hospital from June 2016 to May 2018 to establish a binary variable logistic regression equation for blood pressure elevation or not and screen out the influencing factors of time point blood pressure. The accuracy of the equation was then verified in 252 outpatients. Results Logistic regression analysis showed that PWTT, gender, age, history of hypertension present or not, body height might be the influencing factors of blood pressure elevation [odds ratio (OR) values were 0.995, 0.530, 0.980, 107.128, 0.979, 95% confidence interval (95% CI) were 0.991-0.999, 0.405-0.695, 0.971-0.989, 73.935-155.223, and 0.962-0.996, respectively, all P < 0.05]. The classification prediction equation: Ln [P / (1-P)] = 2.087-0.005×PWTT-0.635×gender (man = 1, woman = 2)-0.02×age + 4.674×hypertension history present or not-0.021×body height [P indicates the probability of a positive result: systolic blood pressure≥140 mmHg (1 mmHg = 0.133 kPa) and/or diastolic blood pressure≥90 mmHg]. The overall test results showed that χ2 = 1 835.305, P < 0.05, statistically significant; The goodness of fit test results:χ2 = 5.881, P > 0.05, the data was conform to the equal proportion distribution. Model-confirmed results showed that in patients with a history of hypertension, the probability of predicting accuracy was 95%-99%. In patients without a history of hypertension, the probability of predicting accuracy was 45%-89%. Conclusion The predictive value of blood pressure elevation with this model in patients with a history of hypertension is superior to that of patients without the history of hypertension.

Objective: To evaluate the effects of the intervention based on WeChat on blood pressure control in patients with essential hypertension. Methods: The databases of CNKI，Wanfang，VIP，PubMed and the Cochrane Library were researched for the literatures about effects of the intervention based on WeChat on blood pressure control in patients with essential hypertension published from 2011 to 2018. These papers were retrieved and evaluated according to inclusion and exclusion criteria. Stata 12.0 software was used for meta analysis. Results: Eleven out of 880 papers were included into meta analysis. There were 1 174 cases，with 587 cases in the experimental group and 587 cases in the control group. The results of the meta analysis showed that compared with traditional health intervention method，the intervention based on WeChat significantly reduced the level of systolic blood pressure（WMD=14.77，95%CI：11.76-17.77）and diastolic blood pressure（WMD=8.17，95%CI：5.67-10.67）of hypertensive patients. Subgroup analysis showed that the longer the intervention，the better the effects（P<0.05）. Conclusion The intervention based on WeChat is more helpful than traditional health intervention for blood pressure control of patients with essential hypertension.

Objective To explore the effects of extended care on aged patients with hip fracture in island area.Methods Forty-Two aged patients with hip fracture,who accepted operation in Department of Orthopedics,Hainan Branch of Chinese PLA General Hospital from June 2014 to November 2015,were enrolled in this study and averagely divided into test group and control group by random number table.Patients in test group received extended care while patients in control group just.3 months after discharge,the differences Harris hip score and Barthel Index were compared between two groups.Results 3 months after discharge in test group,the scores of Harris score and Barthel index were higher compared those of control group (P <0.05). Conclusions Extended care can effectively improve the rehabilitation of aged hip fracture in island area and contribute to patients′self-care.

The correlation coefficients between arterial occlusion pressure and systolic blood pressure, diastolic blood pressure, limb circumference, body mass etc were obtained through healthy volunteer experiments, in which tourniquet were applied on upper/lower extremities. The prediction equations were derived from the data of experiments by multiple regression analysis. Based on the microprocessor C8051F340, a new pneumatic tourniquet system that can determine tourniquet pressure in synchrony with systolic blood pressure was developed and verified the function and stability of designed system. Results showed that the pneumatic tourniquet which automatically adjusts occlusion pressure in accordance with systolic blood pressure could stop the flow of blood to get a bloodless field.
Blood Pressure ; Equipment Design ; Hemostatic Techniques ; instrumentation ; Humans ; Pressure ; Systole ; Tourniquets

Objective:To explore the distribution characteristics of brachial-ankle pulse wave velocity (BaPWV) in adolescents.Methods:Cross sectional survey research.A total of 1 607 adolescents aged 12-17 years from 5 middle schools in the Haidian District, Beijing from June 2020 to May 2021 were enrolled for measuring their blood pressure, weight, height and the body mass index (BMI), including 782 males and 825 females.BaPWV was measured using an arteriosclerosis detector.They were divided by the age, sex and obesity.Differences of measurement data among multiple groups were compared by one-way ANOVA, followed by the LSD test, and those between groups were compared by the two-sample t-test.The correlation between BaPWV and other indexes was assessed by the Pearson correlation analysis. Results:The median level of BaPWV in adolescents aged 12-17 years increased with age, which was 982.50 cm/s in adolescents aged 12 years, and maximum 1 113.50 cm/s those aged 17 years.BaPWV in adolescents aged 12-17 years was positively correlated with age ( r=0.936, P=0.006). Subgrouped by the sex, the median BaPWV of male and female adolescents aged 12 years was 962.25 cm/s and 997.50 cm/s, respectively, which reached 1 122.50 cm/s and 1 096.00 cm/s in those aged 17 years, respectively.BaPWV of male and female adolescents was positively correlated with the age ( r=0.903, P=0.014; r=0.945, P=0.004). In male adolescents, BaPWV was positively correlated the systolic and diastolic blood pressure, age, weight, height, BMI( r=0.308, P<0.001; r=0.289, P<0.001; r=0.478, P<0.001; r=0.190, P<0.001; r=0.315, P<0.001; r=0.109, P=0.002). In female adolescents, BaPWV also was positively correlated the systolic and diastolic blood pressure, age, weight, height, BMI( r=0.340, P<0.001; r=0.285, P<0.001; r=0.379, P<0.001; r=0.115, P=0.001; r=0.170, P=0.001; r=0.097, P=0.014). In the overall population, BaPWV was statistically significant between the obese and normal groups ( t=-3.428, P=0.001). No significant difference in BaPWV between male and female adolescents aged 12-13 years was identified ( t=0.123, P=0.902 ), but it was significantly lower in female adolescents aged 14-15 years and 16-17 years than those of age-matched males( t=2.315, P=0.021; t=2.152, P=0.032). Conclusions:The median BaPWV level in adolescents aged 12-17 years, increases with the age.Systolic blood pressure, diastolic blood pressure, body weight, BMI, age and height are positively correlated with BaPWV in adolescents.Obesity can increase the stiffness of blood vessels, which is influenced by the sex.