Objective:To assess the efficacy and safety of Zyrtec drops which is a patent product of UCBpharma in treatment of allergy rhinitis in children. Method :A total of 47 children of both sexes aged between 2 to6 years with allergy rhinitis (AR) were included in this study,who were randomly selected to be treated withZyrtec (Cetirizine 2 HCL) drops 5 mg daily for 3 weeks. Investigators made a global evaluation with symptomscores before treatment and once a week for 3 weeks after treatment. Result:An improvement was shown in eachweek after treatment with statistical significance (P＜0.01). Zyrtec drops provided an excellent improvement atthe end of the study. Tolerance was good. Conclusion :For acting fast ,potent ,good tolerance and convenience inuse,Zyrtec drops is a better treatment in AR in kids.

OBJECTIVE:To evaluate the derma safety of miconazole and chloramphenicol cream (MCC) for Guinea pigs.METHODS:Blank matrix,positive sensitizing agent (2,4-dinitro-chlorobenzene) and MCC (high dose and low dose) were applied on normal or damaged areas of the unhairing backs of Guinea pigs to conduct acute toxicity test,sensitivity test and irritation test,respectively.RESULTS:MCC caused no acute toxicity when applied on the skin of Guinea pigs,nor skin/systemic hypersensitive reaction was noted after repeated sensitization.Single or multiple dosing of MCC caused no irritation on normal skin of Guinea pigs but caused mild irritation on damaged skin which disappeared after 48 h or 72 h.CONCLUSION:MCC has good dermo safety for Guinea pigs.

Xinjiang Medical University follows the law of medical education and gradualness , has a system re-form for the medical humanities teaching course system , teaching contents , teaching methods by increasing the comprehensive and innovative design , research , teaching and practice teaching content , and trying to build a set of teaching and practice in the integration of medical humanities quality education mode .The first is the emphasis on the whole of medical humanities quality education and systemic .Secondly , we must integrate human resources , strengthen synergy cooperate , common development .The third is to use scientific research project to promote the medical humanism quality education from the ascent of the form content to method means .The fourth is to explore the medical humanistic quality education of the PBL teaching mode .

Objective To evaluate the incidence of hyponatremia in patients with Guillain-Barré syndrom (GBS) and to explore whether hyponatremia is an important predictor of poor outcome.Methods All 455 GBS patients met the inclusion criteria and were divided into three groups as mild,moderate and severe GBS according to Medical Research Council sumscore (MRC sumscore) at nadir.Hyponatremia is defined as serum sodium concentration below 135 mmol/L at nadir.The incidences of hyponatremia in GBS patients with different MRC sumscore were analyzed by x2 tests.Logistic regression models were performed to determine risk factors of hyponatremia and poor prognosis.Results Of all the 455 GBS patients,mild,moderate and severe groups patients were 178,100 and 177 respectively,and 98 (21.5％) GBS patients had hyponatremia.Hyponatremia was more often detected in severe GBS cases (64,36.2％),than in mild (21,11.8％) or moderate (13,13.0％,x2 =28.921,17.074 respectively; all P ＜ 0.01) cases,but there was no significant difference between mild and moderate patients (x2 =0.086 ; P =0.769).Logistic regression analysis identified 3 predictors of hyponatremia:age ＞ 50 (OR =2.013,95％ CI 1.155-3.508,P =0.014),facial weakness (OR =2.493,95％ CI 1.423-4.369,P =0.001) and mechanical ventilation (OR =12.871,95％ CI 5.484-30.207,P =0.001).The presence of hyponatremia (OR =12.770,95％ CI3.419-47.701,P =0.001) and bulbar weakness (OR =3.391,95％ CI 1.182-9.733,P =0.023)predicted death in acute stage.Conclusion As an important predictor of poor outcome in GBS patients,hyponatremia is more likely occurred in patients with older age,facial weakness or respiratory failure.

Objective:To observe the effect of acupoint injection with Neostigmine Methylsulfate at Zusanli (ST 36) on gastrointestinal function of patients after laparoscopic cholecystectomy. Methods:Totally 120 patients undergone laparoscopic cholecystectomy were randomized into an acupoint injection group, a muscular injection group, and a blank control group at 1:1:1 by random number table, 40 cases in each group. The blank control group was intervened by conventional post-operation treatment, the acupoint injection group was by acupoint injection with Neostigmine Methylsulfate 2 mL at bilateral Zusanli (ST 36) in addition to the treatment given to the blank control group, and the muscular injection group was by muscular injection with Neostigmine Methylsulfate 2 mL in addition to the treatment given to the blank control group. The two injection groups both received injection twice a day, totally for 3 d at most. The restored time of bowel sounds, initial flatulence time, defecation time and clinical efficacy were observed. Results:After treatment, there were significant differences in comparing the restored time of bowel sounds among the three groups (F=17.30,P<0.05), the acupoint injection group and muscular injection group were significantly different from the blank control group (P<0.05), and there was a significant difference between the acupoint injection group and muscular injection group (P<0.05); there were significant differences in comparing the initial flatulence time among the three groups (F=19.12,P<0.05), and the acupoint injection group was significantly different from the muscular injection group and the blank control group (P<0.05); there were significant differences in comparing the initial defecation time among the three groups (χ2=21.23,P<0.05), while the difference between the acupoint injection group and muscular injection group was statistically insignificant (P>0.05). The total effective rate was 87.5% in the acupoint injection group, versus 72.5% in the muscular injection group and 60.0% in the blank control group, and there were significant differences among the three groups (P<0.05). Conclusion:Acupoint injection with Neostigmine Methylsulfate at Zusanli (ST 36) can shorten the restored time of bowel sounds and flatulence time in patients undergone laparoscopic cholecystectomy, and the efficacy is more significant compared to muscular injection with Neostigmine Methylsulfate.

Objective To explore CT findings of pulmonary non‐tuberculosis mycobacteria (NTM ) disease .Methods Forty‐two patients with pulmonary NTM disease confirmed by the biphasic medium flora identification (NTM group) ,and 60 patients with lung tuberculosis (TB group) confirmed by the tubercle bacillus cultivation and flora identification in our hospital were included in the ret‐rospective analysis .9 CT signs and distribution features of the lesions were analyzed and compared between the two groups .The difference was statistically significant if P<0 .05 .Results Pulmonary NTM disease was more common in female patients (χ2=5 .500 ,P=0 .019) ,and the mean age was significantly older than that of the tuberculosis (t=3 .456 ,P=0 .001) .The detection rate in the right middle lobe and left tongue section was high in NTM group than in TB group (χ2 =8 .361 ,P=0 .004) .Logistic regression showed that bronchiectasis and bronchial stenosis or occlusion were independent risk factors for the NTM disease .They were important signs for the differential diagnosis from tuberculosis .Conclusion MSCT findings of pulmonary NTM disease have certain characteristic , which are helpful for the diagnosis .

Environmental enrichment has become a hot topic in laboratory animal science , which is intended to im-prove the well-being of laboratory animals .This paper reviews the research in this area , focusing especially on the princi-ple and procedure of planning enrichment strategies .The consideration of housing laboratory animals should not only focus solely on animal well-being, manpower and economics , but also on the precision and accuracy of the experimental results . It also introduces the type of environmental enrichment and practice in widespread use currently .

Gram-negative bacteria are the common pathogens causing nosocomial infections.The drug resistance of gram-negative bacteria has become increasingly serious in last two decades.Carbapenems were once considered as the last line of defense against serious infections of gram-negative pathogens.As carbapenemase-producing strains are spreading, the incidence of infections caused by carbapenem-resistant isolates is increasing worldwide.The pathogens are usually multiple drug resistant strains or extensively drug resistant strains, and effective treatment options are limited, even there are no more drugs in certain conditions.This article focuses on appropriate antibiotics and therapeutic strategies for effective control of infections with carbapenem-resistant gram-negative pathogens.

OBJECTIVE: To investigate the characteristics and regularity of antineoplastic medicine-induced adverse drug reaction (ADR) occurred in our hospital. METHODS: 162 antineoplastic medicine-induced ADR cases reported in our hospital from 2005 to 2008 were analyzed statistically in respect of patients’age and sex, categories of drugs, route of administration, drug combination,organs and systems involved in ADR and clinical manifestation, etc. RESULTS: Of the total 162 ADR cases, proportion of men was similar to women. 68 cases (41.98%) were old persons aged older than 60. 123 cases(75.93%) were single use of drugs, 39 cases(24.07%) were combined use of drugs. 39.51% of ADR cases were induced by antineoplastic medicine made from plants and took up the first place in terms of incidence of ADR. 36.42% of ADR cases dominantly manifested as lesion of skin and its appendants. CONCLUSION: ADR monitoring of antineoplastic medicine should be strengthened to ensure rational and standardized use of antineoplastic medicine, avoid or reduce the occurrence of severe ADR.

OBJECTIVE: To establish an HPLC method for simultaneous determination of the contents of Chlorogenic Acid and Coffeic Acid in the Fruit of Chaenomeles. METHODS: HPLC was applied to determine and compare the contents of 11 batches of Chaenomeles medicinal materials collected at different time, prepared with different process and stored for different length of time, using Coffeic Acid and Chlorogenic Acid standard substances. The chromatogram conditions were as follows: Kromasil C18( 250mm? 4. 6mm, 5? m) column; mobile phase of ( A) acetonitrile, ( B) 0. 05% phosphoric acid; gradient el-ution ( 0～ 10min, 0% A～ 15% A, 100% B～ 85% B; 10～ 40min ( 15% A～ 30% A , 85% B～ 70% B) ; flow rate at 0. 8 mL? min- 1; detection wavelength at 325nm. RESULTS: The content of Chlorogenic Acid in batches 1 to 9 were respectively 0. 020% , 0. 035% , 0. 043% , 0. 051% , 0. 260% , 0. 104% , 0. 081% , 0. 056% , 0. 034% ; that of Coffeic Acid were respectively 0. 005% , 0. 006% , 0. 008% , 0. 010% , 0. 051% , 0. 024% , 0. 020% , 0. 015% , 0. 007% . The contents of Chlorogenic Acid and Coffeic Acid in batch 8’ ( burn- prepared) were respectively 0. 045% and 0. 010% ; those of Chlorogenic Acid and Coffeic Acid in batch 9’ ( stored for 1a) were respectively 0. 023% and 0. 005% . CONCLUSIONS: The method is simple, reproducible and suitable for the quality control of Fruit of Chaenomeles. The best time for harvesting batch 5 is on July 12, and the best process for this batch is solarization. The storage time has certain influence on the content of Chlorogenic Acid.