Objective:To assess the efficacy and safety of Zyrtec drops which is a patent product of UCBpharma in treatment of allergy rhinitis in children. Method :A total of 47 children of both sexes aged between 2 to6 years with allergy rhinitis (AR) were included in this study,who were randomly selected to be treated withZyrtec (Cetirizine 2 HCL) drops 5 mg daily for 3 weeks. Investigators made a global evaluation with symptomscores before treatment and once a week for 3 weeks after treatment. Result:An improvement was shown in eachweek after treatment with statistical significance (P＜0.01). Zyrtec drops provided an excellent improvement atthe end of the study. Tolerance was good. Conclusion :For acting fast ,potent ,good tolerance and convenience inuse,Zyrtec drops is a better treatment in AR in kids.

OBJECTIVE:To evaluate the derma safety of miconazole and chloramphenicol cream (MCC) for Guinea pigs.METHODS:Blank matrix,positive sensitizing agent (2,4-dinitro-chlorobenzene) and MCC (high dose and low dose) were applied on normal or damaged areas of the unhairing backs of Guinea pigs to conduct acute toxicity test,sensitivity test and irritation test,respectively.RESULTS:MCC caused no acute toxicity when applied on the skin of Guinea pigs,nor skin/systemic hypersensitive reaction was noted after repeated sensitization.Single or multiple dosing of MCC caused no irritation on normal skin of Guinea pigs but caused mild irritation on damaged skin which disappeared after 48 h or 72 h.CONCLUSION:MCC has good dermo safety for Guinea pigs.

ObjectiveTo compare the differences in stroke subtype classification between ASCO and modified TOAST.MethodsAll 425 first-ever ischemic stroke patients were recruited and classified into different stroke subtypes according to the ASCO and modified TOAST criteria.Results Comparing ASCO grade 1 with modified TOAST,more patients were classified as atherosclerosis (60.2％ vs 57.9％ ; x2 =2.68,P=0.132) and fewer as small artery disease and cardiac disease subtype (13.4％ vs 14.8％ and 8.5％ vs 8.7％ ; x2 =1.30 and 0.00,P =0.238 and 1.000,respectively).ASCO grade 1 did not reduce the proportion of cause undetermined patients compared with modified TOAST ( 15.5％ vs 16.2％ ; x2 =0.09,P =0.795 ). Agreement was showed in every subtype categories between the two approaches.Agreement for atherosclerotic cause and small artery disease was very good ( all κ over 0.81 ),and for the cardiac disease subtype was good (κ: 0.61-0.80). Conclusion Agreement can be found in every subtype categories between ASCO and modified TOAST classification.ASCO grade 1 does not reduce the proportion of cause undetermined cases compared with modified TOAST,but the subtype categories characteristics of the two approaches should be considered in practice.

ObjectiveTo retrospectively investigate the incidence,outcome and risk factors of HBV reactivation in HBsAg-positive a patients with gastric carcinoma during cisplatin-based adjuvant chemotherapy.Methods We retrospectively reviewed the records of 2,538 patients with gastric carcinoma who received adjuvant chemotherapy from January 2005 to December 2010.Among these patients,146 HBsAg-positive patients were analyzed for the HBV reactivation in this study.The HBV serology and biochemical tests of the 146 patients were performed.The data were analyzed by chisquare test.Results Among 146 HBsAg-positive patients with gastric carcinoma,43 patients (29.5％) developed hepatitis,of which 29 (19.9％) were related to HBV reactivation.Univariate analysis showed that age ≥51 years (P=0.029) and abnormal liver uhrasonography findings such as fatty liver or early cirrhotic changes (P=0.031) were associated with HBV reactivation.However,gender,HBeAg positive status and the use of corticosteroids were not related with HBV reactivation.Conclusions HBV reactivation occurs in a significant proportion of HBsAg-positive patients with gastric carcinoma during adjuvant cisplatin-based chemotherapy.Once hepatitis developed,most patients could not finish the chemotherapy as planned despite lamivudine treatment.Therefore,HBsAg-positive gastric carcinoma patients should initiate prophylactic antiviral treatment before chemotherapy.

Xinjiang Medical University follows the law of medical education and gradualness , has a system re-form for the medical humanities teaching course system , teaching contents , teaching methods by increasing the comprehensive and innovative design , research , teaching and practice teaching content , and trying to build a set of teaching and practice in the integration of medical humanities quality education mode .The first is the emphasis on the whole of medical humanities quality education and systemic .Secondly , we must integrate human resources , strengthen synergy cooperate , common development .The third is to use scientific research project to promote the medical humanism quality education from the ascent of the form content to method means .The fourth is to explore the medical humanistic quality education of the PBL teaching mode .

Objective To evaluate the incidence of hyponatremia in patients with Guillain-Barré syndrom (GBS) and to explore whether hyponatremia is an important predictor of poor outcome.Methods All 455 GBS patients met the inclusion criteria and were divided into three groups as mild,moderate and severe GBS according to Medical Research Council sumscore (MRC sumscore) at nadir.Hyponatremia is defined as serum sodium concentration below 135 mmol/L at nadir.The incidences of hyponatremia in GBS patients with different MRC sumscore were analyzed by x2 tests.Logistic regression models were performed to determine risk factors of hyponatremia and poor prognosis.Results Of all the 455 GBS patients,mild,moderate and severe groups patients were 178,100 and 177 respectively,and 98 (21.5％) GBS patients had hyponatremia.Hyponatremia was more often detected in severe GBS cases (64,36.2％),than in mild (21,11.8％) or moderate (13,13.0％,x2 =28.921,17.074 respectively; all P ＜ 0.01) cases,but there was no significant difference between mild and moderate patients (x2 =0.086 ; P =0.769).Logistic regression analysis identified 3 predictors of hyponatremia:age ＞ 50 (OR =2.013,95％ CI 1.155-3.508,P =0.014),facial weakness (OR =2.493,95％ CI 1.423-4.369,P =0.001) and mechanical ventilation (OR =12.871,95％ CI 5.484-30.207,P =0.001).The presence of hyponatremia (OR =12.770,95％ CI3.419-47.701,P =0.001) and bulbar weakness (OR =3.391,95％ CI 1.182-9.733,P =0.023)predicted death in acute stage.Conclusion As an important predictor of poor outcome in GBS patients,hyponatremia is more likely occurred in patients with older age,facial weakness or respiratory failure.

AIM: To establish the method for quality control of Guipi Pills(concentrated pill) (Radix Codonopsis,Rhizoma Atractylodis macrocephalae,Radix Astragali,Radix et Rhizoma Glycyrrhizae,etc).and a quantitative method of determining astragaloside IV. METHODS: Radix Codonopsis,Radix Angelicae Sinensis,Radix et Rhizoma Glycyrrhizae and Radix Aucklandiae in the pill were identified by TLC.Astragaloside IV in the pill was determined by HPLC-ELSD. RESULTS: For astragaloside IV,the linear range was within 25.4-508.3 ?g and the average recovery was 99.1%,r=0.999 7 with RSD of 0.8%. CONCLUSION: The method is simple,reliable,accurate,practical.It can be used in the quality control of Gui Pipills(concentrated pills).

Objective To observe the expressional changes of pro nerve growth factor(proNGF)apoptosis pro-signal factors after cerebral ischemia and reperfusion and discuss the protective effect of mild hypothermia on the brain injury. Methods The randomly chosen female SD rats weighing(220±10)g were divided into normal control group(Group A),cerebral isehemia and reperfusion group (Group B)and mild hypothermia group(Group C).Groups B and C were divided into 3,6 and 9 hours subgroups(eight rats per group).TUNEL methods was used to detect the apoptotic cells in the cortex after cerebral ischemia and reperfusion and treatment with mild hypothermia.The reverse transcription polymerase chain reaction(RT-PCR)was used to detect the expression changes of proNGF,Sortilin and P75gene in the cortex. Results (1)The apoptotic cells were increased with time in the Group B(P<0.05)and were more than those in the Group C in the same time point(P<0.05).(2)There found expression of all factors at all time points in three groups,which was increased with time(P<0.05).(3)The content of every factor at each time point in the Group C was less than that in the Group B(P<0.05). Conclusions (1)Mild hypothermia can decrease the apoptosis after ischemia and reperfusion injury.(2)The cell apoptosis induced by proNGF plays a very important role in the COUrse of cerebral ischemia and reperfusion injury.(3)Mild hypothermia can decrease the expression of apoptosis pro-signal to alleviate the cell apoptosis and protect the brain from ischemia and reperfusion.

A simple method for in vitro production of sporangia by Phytophthora boehmeriae causing cotton boll blight in China was developed, and a method for dilution of zoospore suspensions was presented as well, Large amounts of sporangia were obtained when mycelial mats, produced from Potato extract-Dextrose Liquid (PDL) or Bean extract-Dextrose Liquid (BDL) at 24 ℃ for 48—72 hr ,were rinsed with Mineral Salt Solution (MSS) four times at 20—22℃ for 10—12 h with continuous fluorescent light (cool white), and incubated for additional 12 h after drained off MSS. Darkness favored oospore whereas suppressed sporangial production by P. boehmeriae. BDB is superior to PDB in the production of oospores and sporangia by P. boehmeriae as evidenced by the amount of sporangia or oospores and in particular the fact that the color change of mycelial mats from light orange to purple was synchronous with the sporulation of P. boehmeriae. Tris-succinate buffer(pH6.8, 5.0mmol/L, TSB) was the quantitatively excellent diluent for preserving motility of zoospores of P. boehmeriae in the dilution process.

Objective To detect the HLA DRB1*12 by use of a new genotyping method for HLA SYBR Green Ⅰ PCR. Methods 1 HLA DRB1*12 sample and 12 unknown clinical sample were collected. The typing of these samples were determined by PCR, which includes a fluorescence dye, SYBR GreenⅠ,and the sequence specific primer. SYBR GreenⅠcould bind to the dsDNA to exhibit fluorescence. The fluorescence enhancement depends on the accumulation of the amplified product. Results 3 of the 12 unknown sample was proved to be DRB1*12 by the analysis of the melting curve of the amplified products. After purification, the type of these products were confirmed DRB1*12 by DNA based sequencing. Conclusions The results of SYBR GreenⅠPCR demonstrate that it can be a new strategy for HLA typing because of its convenience and accuracy.