After the concept of data curation and its application in foreign countries were described , the key points of data curation for data service in special libraries and related problems were analyzed according to the overall needs and changes of users in special libraries.

Objective To study the influence of UPPP on resonance characteristics of four resonance cavity in patients with OSAHS .Methods Using multi-channel voice analysis system to test the cavity resonance character-istics and energy distribution of 36 OSAHS patients (including pre - and post -operative) and 36 normal males when they speak /a:/.The frequency spectrum was 4 000Hz(FR1 ,FR2 ,FR3 ,FR4 ) .Results FR2 energy values of the head cavity and mouth cavity of OSAHS patients heighten significantly after UPPP (P<0 .05);FR1 energy val-ues of head ,mouth and thoracic cavity were higher than that of in normal males'after UPPP(P<0 .05) .FR2 ,FR3 , FR4 energy values of head cavity ,FR2 ,FR3 energy values of mouth cavity ,FR2 energy values of thoracic cavity were lower than those of in normal males'after UPPP(P<0 .05) .Conclusion UPPP surgery removes the obstruction of the upper airway of OSAHS patients and changes the morphology of the pharynx ,thas changes the resonance charac-teristics of the head cavity and oral .

Drupal, a powerful content management system and content management framework, can provide a visiting interface for the mobile terminal equipments , especially the interface for the mobile APP program .How to imple-ment the information pushing function in mobile library using Drupal+PhoneGap was described by constructing the APP program model for information pushing and browsing in mobile library as an example.

After the key technologies used in mobile reading service of library were compared , the authors pointed out that copyright and privacy protection were the major issues challenging the mobile reading service of library.Its development was prospected .

Objective To explore the differentially expressed genes (DEG) involved in the pathogenesis of preeclampsia(PE). Methods The gene expression profiles of placental tissues from 7 severe PE patients and 7 preterm controls from June to December 2012 were assessed using microarray. Gene ontology(GO)enrichment analysis and pathway analysis were performed to explore the genes and pathways involved in the pathogenesis of PE. Four DEG involved in these biological processes were further verified by quantitative real-time PCR. Results A total of 308 transcripts were significantly differentially expressed. Of these DEG,81 genes(LEPTIN,PAPPA2,CRH,PLIN2,INHA,BCL6,FLT1,CCR7,etc)were up-regulated,and 227 genes(CXCL12,CXCL9,etc)were down-regulated. GO enrichment analysis indicated that the top 3 GO molecular functions were immune response(GO: 0006955,17 DEG),positive regulation of apoptosis(GO: 0043065,11 DEG)and inflammatory response(GO: 0006954,11 DEG). Pathway analysis showed that the top 3 pathways were cell adhesion molecules(11 DEG),cytokine-cytokine receptor interaction(11 DEG),chemokine signaling pathway(8 DEG). Many genes(LEP,FLT1,TFRC,SH3PXD2A, CYP11A1,SEPP1,and so on)involved in oxidative stress were found to be significantly changed. Of these genes,LEP were significantly up-regulated with a fold change of 61.5. The fold changes of FLT1, SH3PXD2A,SEPP1,CYP11A1,TFRC were 8.6,2.2,-2.0,2.7 and-2.8. Four DEG involved in oxidative stress were further verified by quantitative real-time PCR. Conclusions A DEG signature was identified in severe preeclampsia placentas compared with normal controls. The DEG mainly involved in the molecular mechanisms of immune response,oxidative stress and inflammatory response,and were closely associated with the pathogenesis of PE.

After the meaning, features and application models of CDP technology were described, its application in protecting data in libraries was studied with Medical Library of Chinese PLA as an example, showing that CDP technology can effectively protect the data, improve their safety, and insure the stable operation of professional sys-tems in Medical Library of Chinese PLA.

After the definition and emergence of MOOC and its development at home and abroad were described, the position of library under MOOC environment was discussed with stress laid on how to deepen the service in medical library by making use of MOOC and the challenges medical library is faced.

Objective To assess the clinical outcome of short segment fixation in combination of pedicle screw in injured vertebrae for thoracolumbar fractures. Methods Twenty-one cases of thoracolumbar fractures received short segment fixation combined with pedicle screw in injured vertebrae surgery. The protruding after angle correction and vertebral body height recovery situation were measured by X-ray film before and after surgery. Results All the patients were followed up for 6~20 months,achieved good reduction effect. The imaging measure-ment results found that before the operation Cobb’s angle was (26. 4 ± 7. 3),fracture fanterior flange height was (56. 1 ± 12. 5)%. Com-pared with after the operation and the end of follow-up of Cobb’ s and fracture fanterior flange height,the difference had statistical significance (P<0. 05). But between after the operation and the end of the follow-up of Cobb’s and fracture fanterior flange height,the difference had no statistical significance (P>0. 05). Conclusion Short segment fixation in combination of pedicle screw in injured vertebrae can restore the height of vetebra,rectify protrusion deformity,which is an effective method for thoracolumbar fracture.

Biomarkers ; Humans ; Indium ; Occupational Exposure

Objective To know about recent experience of the quality control of blood clotting,to analyze the reasons for its out-of-control,and then to explore the influencing factors of coagulation tests.Methods According to the testing standards of coagula-tion quality control products of Clinical Laboratory Center,Ministry of Health,each batch of products were taken standardized tests.The external quality control results of blood clotting from 2009 to 2013 were analyzed and counted up combined with the in-ternal quality control and daily work performance.Results The overall performance of external quality control was good (from 2009 to 2013).The total scores in 2009 were 90%,95%,were 100% and 100% in 2010,were 95% and 95% in 2011,were 100%and 85% in 2012,and were 100% and 100% in 2013.Conclusion Laboratory internal quality control should be guaranteed.The quality control of pre-analysis,post and analysis and analysis-in-course can improve clinical coagulation testing quality.