Objective To observe and investigate the correlation of hemodynamic change of cerebral vessels and functional disturbance in cerebral infarction patient.Methods To investigate hemodynamic characters of cerebral vessels in every type and every group patients via comparing cerebral infarction group(observe group)with control group,comparing stage of recovery with early stage, sever, moderate, mild degree in observe group.Results Apparent hemodynamic change was observed in above 94.10% cerebral infarction patients. The more apparent the hemodynamic change,the severer the functional disturbance.Conclusion The hemodynamic change of cerebral vessels is the predictive index of state of illness and prognosis of cerebral infarction patient.Clinical doctor should pay enough attention to modify it in treatment.

Objective To explore the effects of YOGA relaxation on anxiety and somatic symptoms in patients with depression. Methods 60 inpatients with depression were ctegorized into the control group and the observation group with 30 cases in each group. HAMD scale were scored before and after medication (2,4,8 weeks). Results Before medication, there was no statistical differenoe between two groups in HAMD total score and subscores, but the difference was obvious in anxiety and somatic, sleep disturbance and hopelessness subscore at the end of the second and 4th week. Conclusions YOGA relaxation can improve anxiety emotion and somatic symptoms, enhance sleep quality in patients with depression.

Objective To investigate the types ,specimen types ,department distribution and drug resistance of multi‐drug resist‐ant bacteria in our hospital during the recent 5 years to provide the scientific guidance for the clinical treatment ,prevention and con‐trol of multi‐drug resistant bacteria .Methods The specimens of laboratory bacterial culture positive during 2011-2015 were col‐lected ,and analyzed on the types ,proportion and drug resistance situation of multi‐drug resistant bacteria and their distribution in clinical specimens and clinical departments .Results A total of 2 568 strains of multi‐drug resistant bacteria were isolated and ac‐counted for 37 .41% the positive specimens ,in which top 5 bacteria were Escherichia coli ,Acinetobacter baumannii ,Staphylococcus aureus ,Klebsiella pneumoniae and Pseudomonas aeruginosa;the sputum ,midstream urine ,blood and secretions had the higher posi‐tive rate of multi‐drug resistant bacteria ,while the secretions from the catheter tip and ear discharge had the lower positive rate(P<0 .05);the multi‐drug resistant bacteria had difference among different departments ,in which ICU ,respiratory department and sur‐gery department were highest ,while the lowest was in the spleen and stomach department and breast department ;the resistance of multi‐drug resistant bacteria occurred over a wide range ,which had higher resistance to beta lactam and aminoglycosides and had higher sensitivity to compound antibacterial drugs such as sulfamethoxazole antibiotics and enzyme inhibitors .Conclusion Multi‐drug resistant bacteria are more and more common in clinic .The positive rate is increased year by year .The drug resistant strains widely distributed .The clinical departments should pay high attention to .Rational and scientific use of antibacterial drugs ,strict control of multi‐drug resistant bacterial spread and strength of the patients′isolation have an important significance to effectively prevent and control the multi‐drug resistant bacterial spread .

51 cases of osteoporosis were put on clinical trial in our OPD and randomly assigned to TCM treatment group (N = 17), TCM control group and blank group. The total effective rate in the TCM treatment group obtained was 94. 1% and the significantly effective rate achieved 88. 2%. After the treatment, the density of the osseous tissue increased by 3-4%, main symptoms improved markedly, the serum calcium increased and the urine pyridine phenol decreased. All the findings were superior than that in the rest two groups. This composite is effective and safe (no side reactions) and worth put into large sale production.

Objective To explore the effects and molecular mechanisms of arsenic trioxide(As 2O 3) in inducing apoptosis of colonic cancer cell line SW480. Methods The morphologic changes and apoptotic rate of SW480 cells induced by As 2O 3 were observed with fluorescent microscopy and flow cytometry. The bcl-2 and Fas expressions induced by As 2O 3 in SW480 cells were examined by immunohistochemical method. Results 24 hours after exposed to As 2O 3, SW480 cells exhibited typical morphologic changes of apoptosis, the apoptotic rate of which was 2.1%～10.6%. A typical subdiploid peak before G 1 phase was observed by flow cytometry, and As 2O 3 mainly acted in G 2/M phase. As 2O 3 decreased bcl-2 expression and increased Fas expression in SW480 cells. Conclusion As 2O 3 could induce apoptosis of SW480 cells. The molecular mechanism of As 2O 3-induced apoptosis of SW480 cells might be down-regulating the bcl-2 expression and up-regulating the Fas expression.

ObjectiveTo investigate the effect of pumping haematoma from vertebrae and skull with CT locating to treat hypertensive intracerebral hemorrhage.MethodsThe cases were divided into 2 groups:the operation group(89 cases),in which patients were given the approach of pumping haematoma from vertebrae and skull on the basic of internal medical treatment, with the help of head CT locating, and the control group(71 cases),in which the internal medical treatment was used only. ResultsThe survival rate,the death rate,the complications and the nerve function recovery in the operation group after 20 days and 6 months were improved compared with that in the control group(P<0.01).ConclusionThe approach of pumping haematoma from vertebrae and skull is a safe,effective,practical and easy method in treating hypertensive intracerebral hemorrhage.

OBJECTIVE:To systematically review the efficacy and safety of Magnesium isoglycyrrhizinate injection versus 4 comnon medicines in the treatment of drug-induced liver damage,and to provide evidence-based reference for clinic treatment. METHODS:Retrieved from PubMed,EMBase,Cochrane Library,CBM,CJFD,Wanfang Database and VIP Database,random-ized controlled trials (RCT) about Magnesium isoglycyrrhizinate injection versus other medicines in the treatment of drug-induced liver damage were enrolled. Meta-analysis was performed by using Rev Man 5.3 software after literature selection,data extract and quality assessment. RESULTS:A total of 13 RCTs were included,involving 1 093 patients. Results of Meta-analysis showed clini-cal effective in magnesium isoglycyrrhizinate group was significantly higher than tiopronin group[RD=0.29,95%CI(0.17,0.42), P<0.001] and diammonium glycyrrhizinate group [RD=0.07,95%CI(0.01,0.12),P=0.02],compared with glutathione group and compound ammonium glycyrrhetate group,there were no significant differences ;incidence of adverse reactions in magnesium iso-glycyrrhizinate group was significantly lower than diammonium glycyrrhizinate group [RD=-0.07,95%CI(-0.11,-0.03),P<0.001] and compound ammonium glycyrrhetate group[RD=-0.21,95%CI(-0.38,-0.04),P=0.02],compared with triopro-nin group and glutathione group,there were no significant differences among 3 groups. CONCLUSIONS:Magnesium isoglycyrrhiz-inate injection has better efficacy and safety than other 4 commons hepatoprotective medicines in the treatment of drug-induced liver damage. Due to the limit of methodological quality,more large-scale and long-term follow-up studies with strict designed are need-ed for the further verification of the conclusion.

Objective To investigate the difference of clinical efficiency and safety in obsessive-compulsive disorders (OCD) treatment with escitalopram or paroxetine.Methods A total of 156 OCD patients were randomly divided into escitalopram group (ESC group) and paroxetine group (PAR group).Yale-Brown Obsessive Compulsive Scale (Y-BOCS),Hamilton Depression Scale (HAMD) and Treatment Emergent Symptom Scale (TESS)were used to evaluate the clinical efficiency and safety before and after1,2,4,6,8 weeks treatment.Results The cure rate(21.79％ vs 17.95％) and effective rate(70.51％ vs 71.79％) had no statistically difference between ESC group and PAR group,and incidence of side effect had no significant difference between two groups(x2 =1.99,P＞0.05).Compared with the group before treatment,HAMD scores were significantly decreased from the first weekend in ESC group,but in PAR group HAMD scores did not decrease until the second weekend,and the differences were also significant(P＜0.05).Conclusion Escitalopram is a safety,effective and well-tolerated drug in the treatment of obsessive-compulsive disorder.

Objective To explore the effect of psychological rehabilitation on patients with limb motor dysfunction. Methods 136 cases of hospitalized patients who needed rehabilitation therapy and training were divided into observation group and control group. The control group received conventional rehabilitation, and the observation group received psychological rehabilitation (psychotherapy and medicine) in addition. Symptom Checklist-90 (SCL-90), Fugl-Meyer Assessment (FMA) and modified Barthel Index (MBI) were assessed before and 8 weeks after treatment. Results Most of the 136 patients were involved in psychological problems, including anxiety, depression, somatization,fear, hostility. There was no difference in the scores of SCL-90, FMA and MBI between 2 groups before treatment (P>0.05). After 8 weeks treatment, the scores of SCL-90 were lower, except psychotism (P>0.05), in the observation group than in the control group (P<0.05),the scores of FMA and MBI were higher in the observation group than in the control group (P<0.01). Conclusion The psychological rehabilitation plays an important role in rehabilitation of limb motor dysfunction.

Objective To compare the effects of atypical antipsyehoties treatment on PS0 sensory gating in first-episode schizophrenics. Methods The P50 auditory evoked potential was recorded by using conditioning-testing stimulus paradigm and stimulus train paradigm in 36 normal controls and 53 first-episode schizophrenics be-fore and after treatment,and compare the difference of P50 sensory gating after treatment. Results Before treat-ment, compared with control group, the atypical groups both had statistic difference of T-P50 amplitude ((1.01±0.88)μV, (0.68±0.64)μV, (0.58±0.47)μV), P50 suppression ((0.61±0.27), (0.54±0.22, (0. 59± 0.19)) in conditioning-testing stimulus paradigm and P50 amplitude,P50 suppression evoked by high frequency stimuli in stimulus train paradigm(P < 0.05), but no difference among the atypical groups (P > 0.05). After treat-ment,compared with control group, there was no statistic difference in olanzapine and elozapine groups of T-P50 amplitude and P50 suppression in conditioning-testing stimulus paradigm, but the difference in risperidone and que-tiapine groups still obviously(P<0.05). In stimulus train paradigm, there was no statistic difference of P50 ampli-tude, P50 suppression evoked by high frequency stimuli in every groups (P>0.05). Compared within atypical groups, the difference of P50 amplitude and P50 suppression were both obviously(P<0.05). Conclusion Each a-typical antipsychotic has different effect on P50 sensory gating;and the conditioning-testing stimulus paradigm and stimulus train paradigm P50 sensory gating may reflect different central neuron mechanism.