In the view of physiology,sleep can be described as an important modulatory factor for hormone release,glucose regulation,and cardiovascular function.The circadian rhythms of hormones is mainly associated with sleep,which is largely mediated by neuroendocrine system.Sleep deprivation will disrupt this rhythm,leading to a series of metabolic diseases.We published an article in 《J Clin Endocrinol Metab》 titled Association between sleep duration,daytime nap duration,and osteoporosis varies by sex,menopause,and sleep quality,which suggested that sleep durations of 7-8 h/day,9-10 h/day,and ≥ 10 h/day,as well as longer daytime napping times,tend to present higher risks of having osteoporosis,and this tendency is especially obvious in postmenopausal women reporting good quality sleep.

Background Traditional Chinese medicine (TCM), especially herbal medicine, has been widely used in China and now is also being increasingly used in other countries for the treatment of cardiovascular diseases. Although many studies have demonstrated that certain Chinese herbal products are effective and safe for the treatment of cardiovascular diseases, most of these lack sufficient quality. Therefore, large randomized clinical trials and further scientific research to determine its safety, effectiveness are necessary.QiShen YiQi Dripping Pills (QSYQDP) is a herbal preparation clinically used in the treatment and prevention of coronary artery disease. Preliminary observations have shown its safety and effectiveness. Methods/Design This randomized, controlled trial will recruit 3600 patients with a history of myocardial infarction. Patients will be randomized into two groups by a Centr-Randomized System. One group receives QSYQDP, the other group receive aspirin. This trial protocol will describe eligibility criteria, detailed information on the treatment definition, blinding, endpoints, statistical methods, sample size determination, data management, legal aspects, and the current status of the trial. Discussion This trial is one of the first randomized, controlled clinical trial to evaluate the efficacy and safety of traditional Chinese herbal medicine in the treatment and secondary prevention of coronary artery disease. The results of this study should help to define the role of TCM in modern medical care, as well as to provide the management strategy for CAD patients in China and other countries.

Humans ; Severe Acute Respiratory Syndrome ; diagnosis ; therapy