Viral myocarditis involving the cardiac conduction system is easily associated with a variety of arrhythmias. Negative inotropic effect and the potentially induced arrhythmia of antiarrhythmic drugs limit their application. Non-drug treatment with the body injuries and high medical costs holds patients back and leads them to take a conservative treatment. Traditional medical treatment of this disease has a long history and rich experience. Clinical and experimental studies show that traditional Chinese medicine is effective and has few side effects. This article discusses the ideas of treatments of arrhythmia, from three aspects of differentiating diseases and syndrome type, dispelling wind-evil and dredging collaterals and using results of pharmacological researches reasonably.

Eosinophilic gastroenteritis (EGE) is a rare disorder characterized by eosinophilic infiltration of the bowel wall with various gastrointestinal manifestations.The etiology of the disease is not clear.EGE can affect the growth and development in children,and can cause a variety of complications.Through the elaborate discussion to the pathogenesis,clinical manifestations,diagnostic criteria and treatment principles of EGE,can strengthen identification to EGE,and improve the level of diagnosis and treatment.

Objective To explore the prognostic value of resting heart rate(RHR) in patients with coronary heart disease(CAD) after revascularization.Methods The DESIRE-plus(Drug-Eluting Stent Impact on Revascularization-plus) was a single-center registry study of 3631 patients who had coronary revascularization in our institution between 1 July 2004 and 30 September 2005.The patients were followed up by telephone after discharge.We obtained risk estimates for four groups as RHR:

Objective To assess the influence of hemoglobin(Hb) concentrations on long-term mortality in male patients after percutaneous coronary interventions(PCI).Methods The DESIRE-2(The Second Drug-Eluting Stent Impact on Revascularization Registry) is a single-center registry of 6005 patients undergoing coronary revascularization from Jul 2003 to Sep 2005.There were a total of 2 641 PCI male patients without previous treatment with thrombolytic substances and end-stage renal failure before interventional procedure and the baseline hemoglobin data were available.Depending on their baseline hemoglobin,patients were divided in quintiles.We compared the clinical features and prognosis of all these patients.Results Significant differences were found between the quintiles regarding age(P

0.05).Cox multi-variant regression analysis proved that complete coronary revascularization was irrelevant to prognosis.Conclusion Complete revascularization might not improve prognosis of patients with multivessel coronary artery disease and severe or moderate redced glomerular filtration rate reduction.

Objective To investigate and compare the short-term and long-term outcomes between percutaneous coronary intervention(PCI) or coronary artery bypass graft(CABG) in coronary heart disease(CHD) patients comorbid with diabetes mellitus.Methods The DESIRE register study(Drug-Cluting Stent Impact on REvascularization) was a single-center retrospective study which enrolled 3763 patients who received revascularization therapy during two distinct pesiod.Our study included 670 CHD patients from the whole DESIRE population who received revascularization during July 2003 to June 2004 and comorbid with diabetes mellitus.According to the revasularizaton strategy,the patients were divided into the PCI group(n=400) and the CABG group(n=270).Adverse cardiac and vascular events were the composite endpoints which included all-cause of death,non-fatal myocardial infarction,non-fatal stroke and revascularization.Results Baseline data had no difference between the two groups.In-hospital adverse cardiac events in the PCI group was fewer than in the CABG group(0.5% vs 4.1%,P=0.001) as shown by a lower mortality in the PCI group compared with the CABG group(0.5% vs 3.3%,P=0.012).Duration of follow-up in the PCI group and the CABG group was 592.6?121.3 days and 581.5?148.3 days respectively.The incidence s of long-term adverse cardiac events had no differnce between the two groups,but an increase trend was observed in the PCI group compared with the CABG group(14.2% vs 9.0%,P=0.056),owing to a higher percentage of revascularization(8.5% vs 2.1%,P=0.001).Two groups had a similar incidence of death,non-fatal myocardial infarction,non-fatal stroke during the follow-up period.Conclusion With the wide-spread of DES application,in-hospital adverse cardiac events in the PCI group was fewer than in the CABG group especially in terms of mortality.Long-term adverse cardiac events had no differnce between two groups,but PCI group had more revascularization.

Objective To determine the impact of body mass index(BMI)on clinical outcomes in patients underwent coronary revascularization.Methods The DESIRE-plus(Drug-Eluting Stent Impact on Revascularization-plus)was a single-center registry study of coronary revascularization in our institution between 1 July 2004 and 30 September 2005.We analyzed patients with complete data of BMI from the DESIRE-plus trial,grouped by BMI(low BMI group:BMI

Objective:To study the roles of TNF ? and IL 8 in the onset of brain edema induced by lipopolysaccharide in rat.Methods:RIA and ELISA methods were used to measure the contents of TNF ? and IL 8 in brain tissue in vivo after brain edema induced by LPS in rat Results:The levels of TNF ??IL 8 in brain tissue in LPS group were succesively increased and had noted difference compared with A group?NS group( P

Ketoconazole(KET) is a new imi-dazole derivative with broad antimycotic spectrum. In order to verify the clinical toxic and side effect and its properties in animals, we made a long-term toxicity test for 30 days. Dosages of 70, 35 and 17. 5 mg?kg-1?d-1(e-quivalent to 21, 10. 5 and 5. 2 times of the clinical dosage) were given ig to dogs. The salivation , vomiting, anorexia, decrease in heart rate and loss of weight occurred in the large dosage group. Half of the dogs died from toxicosis within ig 15 days. Laboratory examination showed that the activities of ALT, LDH and ALP, the content of T-BIL, BUN in serum in-creased in this group. Pathological examination revealed that there were some pathological changes in the liver, kidneys, adrenal glands and sex gland in the group. There were no significant changes in other dosage groups compared with the normal control group. After withdrawal of KET, all toxic symptoms disappeared and the abnormal indexes were restored. The results indicated that toxic target organs of KET were liver, kidney, adrenal gland and sex glands. The safe dosage for dogs was about 17. 5 mg?kg-1?d-1.

BACKGROUND: Besides being a basic growth factor crucial to maintain and promote the development, differentiation and survival of the central nervous system, nerve growth factor(NGF) also plays an important role in the repair of injured peripheral nerves.OBJECTIVE: To investigate the effect of the muscular injection of NGF on the regeneration and functional recovery of rat sciatic nerve after crush injury.DESIGN: A randomized controlled pilot study in rats with repeated observation and measurement.SETTING: Center for new drug evaluation in a military medical university.MATERIALS: This study was performed in the Center for New Drug Evaluation, Department of Basic Medicine, Second Military Medical University during the period from July 1999 to March 2000, using 40 SD rats weighing 200 to 250 g(of either sex of half number) provided by the Sino-British SIPPR/BK Lab Aninal Ltd (Shanghai).METHODS: Forty rats were randomized into high-, mid- and low-dose NGF treatment groups, normal control group and model control group. The sciatic nerves were clamped at 6 nm distal to the sciatic notch to induce a 4-mm-wide area of crush injury. In the high-, mid-; and low-dose NGF groups, the rats were given NGF at 8, 4 and 2 μg/kg per day(corresponding to 1.6 × 10 3, 8 × 10 2 and 4 × 10 2 IU/kg per day) respectively via the muscular injection for 56 consecutive days.(NCVs) and sciatic function index(SFI) at different time points after the RESULTS: Compared with that of the model control group, the NCVs significantly increased in the high-dose NGF group 35 and 56 days after the injury,and in the mid-dose NGFgroup at 35 days(t=2.32-5.14, P ＜0.05-0.01 ). The SFIs significantly increased in all NGF-treated groups at 14 days ( t = 2. 29-6.28, P ＜ 0.05-0.01 ), with the recovery most conspicuous in high-dose NGF group; No significant difference in the SFIs was found between the NGF-treated groups on the 56th day. Morphological examination of the tissues identified no significant difference in the nerve myelin sheaths and axons in NGF-treated groups as compared with the normal control group,while in the model control group, myelin sheath dislocation with unclear microstructure was observed, accompanied by Schwann cell degeneration and necrosis.CONCLUSION: NGF promotes the repair of the damaged nerve myelin sheath and axon and stimulates nerve fiber regeneration and function recovery of the crushed rat sciatic nerves.