Autism is a pervasive developmental disorder characterized by deficits in socialization, communication, and adaptive functioning. To investigate its neurophysiology, lots of measures have been used. In the past twenty years, due to its evaluation function in the central auditory processing and recognition, auditory event related potential has been implemented in autism more and more generally.

The serum lipids and lipoproteins in 15 type Ⅱ nephrotic syndrome were studied and compared with 20 health controls. The serum TC, TG, LDL-C were significantly increased. There were the inverse correlation between serum TC, TG, LDL-C and albumin and the week positive corre ation between serum lipids, lipoproteins and creatinine. These suggested that there be the wide abnormalities of lipids and lipoproteins in type Ⅱ nephrotic syndrome which may be risk factors of cardiovascular disease and progressive renal diseases.

The paper introduces researches related to the discovery mechanism of things and information for the Internet of Things based on P2P, analyzes and compares three kinds of distributed P 2P topological structures , and proposes information discovery for the In-ternet of Things based on unstructured P 2P.This means to use interest -based selection of hierarchical topological construction and the self-adaptable search algorithm based on interest clusters and analyze this algorithm .

Mechanical ventilation as an important treatment is widely used in clinical practice,the high inci-dence of ventilation lung injury in the course of operating it has been increasingly concerned.The basic mechanism, mechaical stress and high tidal volume machine stimulate lung cells,makes the inflammation in the cells changes,that is,it is from mechanical lung damage to biological injury.With the international and domestic in -depth researches on VILI,the application of control measures,like some medication treatment,ECMO,liquid ventilation have reduced the incidence of VILI to a certain extent,the occurrence mechanism and progress of treatment of VILI are reviewed briefly.

Zinc supplementation can reduce the mean duration,the recurrence rate and mortality of diarrhea.Nonetheless,it has no effect on stool frequency or stool output.Zinc supplementation results in different effort for the difference of the duration of diarrhea,pathogens,zinc type and doses of zinc,and shows no effect in infants younger than 6 months.Using iron as a co-intervention can reduce the effect of zinc,but vitamin A or ORS have a synergistic effect with the meeting.Average baseline zinc levels did not contribute to variations in the effect size.Zinc supplements are unlikely to improve compliance with the treatment for diarrheal disease.Longer course,zinc alone,malnutrition,diarrhea,breast-feeding children are prone to vomiting after oral administration of zinc.

Objective To explore the characteristics of deficit in action imitation upon objects for the children with autistic spectrum disorder(ASD). Methods Imitative tasks involved objects under the condition of different time after the modelling action ,different action number, different action meaning were used to examine the variations between 12 young children with ASD,and with deaf children(D) matched with the non-verbal IQ and CA( n= 12) ,and children with mental retardation (MR) matched with verbal IQ and CA( n= 12). Results Analyses of repeated ANOVA revealed that: there were significant main effect on the imitation of action involved objects within three subjects(F(2.33) = 10. 138, P＜0.01 ) ;the individuals with ASD achieved lower scores(0.766 ±0.029 ) than the children with MR (0.861 ± 0. 029 ), and the children with deaf significantly ( 0. 949 ± 0. 029). Especially,the autistic imitation deficit was shown on tasks of deferred and meaningless action imitation. Conclusion Children with ASD show deficit on imitation involved objects significantly.

ObjectiveToinvestigate the effect of different needling methods on ischemic stroke, for seeking the effective treatment for stroke.MethodBy following the randomized controlled principle, the sixty enrolled patients were randomized into an electroacupuncture groupand an acupuncture group, 30 cases in each group. The two groups were both intervened by needling treatment in addition to the conventional internal medicine management, electroacupuncture for the electroacupuncture group,and ordinary acupuncture for theacupuncture group. The Neuropathy Disability Scale (NDS), Fugl-Meyer Assessment (FMA), and Barthel Index (BI) were adopted for evaluation and comparison.ResultThe NDS, FMA, and BI scores were significantly changed after treatment in both groups (P<0.01); there were significant differencesin comparing FMA and BI scores between the two groups (P<0.05).ConclusionElectroacupuncture can produce a more significant efficacy in treating ischemic stroke compared with ordinary acupuncture, electroacupunctureis also better than ordinary acupuncture in improving the neural deficit.

Tryptophan 2,3-dioxygenase (TDO)is the rate-limiting enzyme in the catabolism of Trp along the kynurenine pathway.Trp is mainly catabilized by the TDO in the liver,which could not only regulate the concentration of the Trp and suppress the T cells proliferation,but also participate in antibacterial action and inflammatory response.The metabolin kynurenines as an endogenous ligand of the AhR receptor,the TDO enzymes,Kyn and AhR form the TDO-Kyn-AhR pathway have effects of regulatory the growth of tumor.With the research of the mechanism of immune regulation goes futher,it is expected to be a promising prospect in cancer therapy and the immune tolerance of transplantation.We reviewed in the article,which summarized the TDO mediated catabolism of Trp and immunomodulatory effect.

The paper analyzes the current situation of integration in healthcare industry and the difficulties in the construction of healthcare big data platform,proposes the construction of healthcare big data platform by Cloud P2P network,and the platform framework including the five layers of resource layer,sense/access layer,transfer layer,service layer and application layer.

Objective: To study the relationship between endoplasmic reticulum stress (ERS) and adiponectin;to explore the role of ERS for increasing myocardial ischemic vulnerability in type 2 diabetes mellitus (DM) mice.
Methods: Type 2 DM model was established by high fat diet with streptozotocin (STZ) injection. A total of 35 C57BL/6J male type 2 DM mice were divided into 4 groups: ①Control group, n=5. ②Tauroursodeoxycholic acid (TUDCA) group,③Thapsigargin (TG) group and ④Normal saline group. The mice in Groups ②, ③, ④were fed by high fat and high glucose diet by injecting streptozotocin (STZ), in the last 3 weeks and respectively received intraperitoneal injections of TUDCA (250 mg/kg), thapsigargin (TG) (300μg/kg) and normal saline twice a day, n=10 in each group. Then myocardial infarction (MI) model was established in 5 mice from each group. 72 hours later, the MI ranges were measured, serum levels of adiponectin were detected, mRNA expressions of adiponectin and CHOP in myocardial tissue were examined.
Results: The MI range in TUDCA group (21.47 ± 2.85)%and in Normal saline group (39.92 ± 4.28)%were both lower than TG group (66.56 ± 8.15)%, both P<0.01. Before MI occurrence, serum levels of adiponectin in TUDCA group (79.25 ± 6.40) pg/ml and in Normal saline group (70.23 ± 4.15) pg/ml were both higher than TG group (62.64 ± 5.70) pg/ml, both P<0.01;serum levels of adiponectin in each group were higher than they were 72 h after MI. In each group, the mRNA expression and protein content of adiponectin in myocardial tissue were constant to serum adiponectin;while the mRNA expression and protein content of CHOP was opposite to serum adiponectin.
Conclusion: ESR could increase myocardial vulnerability in type 2 DM mice which might be related to down-regulating adiponectin expression.