Objective To investigate the application of the voice acoustic analysis in the evaluation of curative effects of different chronic laryngitis.Methods The adult patients with chronic laryngitis (80 cases)were divided into 3 different syndrome types what were as the Yin deficiency group (28 cases),the Qi deficiency group (25 ca-ses),and the TanNing blood stasis group (27 cases).According to the different compositions of golden voice series medicines,the medicines were administered,combined in two to three.A total of 30 normal people were set to the control group.The German ATMOS voice test and analysis system was used to detect continuous vowel signals and the results were compared before and after treatment.Results Before the treatment,the chronic laryngitis group, compared with control group,had higher jitters,shimmers and NHR.The MPT was significarry shorter and DSI smaller compared with the control group(P <0.05).After 1 month of medication,the Yin deficiency group was the best and there were no significant differences in almost all parameters compared with control group (P >0.05)ex-cept for the parameter-jitter.The jitter,shimmer,and NHR decreased significantly after 1 month treatment while the MPT and DSI increased significantly in the Yin deficiency group and the Qi deficiency group compared with be-fore treatment (P <0.05).There was a statistically significant difference on jitter,shimmer,NHR and DSI and no difference on MPT compared with before treatment in TanNing blood stasis group.Conclusion The voice acoustic a-nalysis could be objective and quantitative to analysis the chronic laryngitis patients'voice quality with different syn-drome types and evaluate the curative effects.

Central nervous system lymphatic drainage system (CNSLDS) is composed of glymphatic system, perivascular lymphatic drainage pathways and meningeal lymphatic vessels. Based on new findings of structures and functions of CNSLDS, CNSLDS is one of the mechanisms for promoting the clearance of β-amyloid (Aβ). CNSLDS functions physiologically as a route of drainage for Aβ from glymphatic system or perivascular lymphatic drainage pathways to meningeal lymphatic vessels, and the meningeal lymphatic vessels helps Aβ drainage to the nearby lymph nodes. In this review, we summarize the key component elements (structure and function) in the clearance of Aβ during the CNS lymphatic drainage. Also, we highlight their potential roles in the pathogenesis of Alzheimer's disease and their clinical importance in diagnosis and treatment of neurologic diseases associated with Aβ, including Alzheimer's disease.

目的通过循证和专家讨论研究法建立第一版针对脑卒中的一套综合ICF核心分类模板和与之相应的简明ICF核心分类模板。方法来自于不同国家和地区的国际专家从初步研究中搜集证据,结合这些证据进行正式的决策并最终达成共识。初步研究包括Delphi研究方法、对ICF分类的系统评价以及实证数据的收集。结果来自12个不同国家的39位专家出席会议并达成共识。专家初步研究决定在ICF分类的第二、第三和第四级水平上针对脑卒中确定一套448个类目的ICF核心分类摸板,其中193项类目属于身体功能,26项属于身体结构,165项属于活动和参与,64项属于环境因素。综合性ICF核心分类模板包括在ICF分类第二级水平上的130个类目,其中41项属于"身体功能",5项属于"身体结构",51项属于"活动和参与",33项属于"环境因素"。简明型ICF核心分类模板包括在ICF分类第二级水平上的18个类目,其中6项属于身体功能,2项属于身体结构,7项属于活动参与,以及3项属于环境因素。结论专家组通过整合研究过程中的证据,以及专家们基于ICF框架和分类的观点达成正式的共识,并确定针对"脑卒中"的ICF核心分类模板,同时界定综合型ICF核心分类模板和简要型ICF核心分类模板。