OBJECTIVE:To optimize the extraction process of paishi granule.METHODS:The extraction process of paishi granule was optimized by L 9 (3 4 )orthogonal test with total flavonoids as index,and with duration of decoction,times of de?coction,the amount of water added and the amount of alcohol used for extraction as factors of investigation.RESULTS:The optimum extraction condition was the following,the amount of water added to which was12times that of the medical material,and it was decocted120min for3times,which then was dried and crushed,then60%alcohol,which was40times that of the amount of medicinal material,was extracted by refluxing for3times with30min each time,filtered while hot,and the alcohol was recovered.The yield of extractum and the content of the total flavonoids were fairly high,and there was a good repro?ducibility.CONCLUSION:The optimized process is stable and feasible.