Objective To investigate the relationship between the education level of staff members and the risk factors for stroke in a university in China.Methods From January 2014 to May 2014,a total of 659 staff members in a university in China were collected with a cluster sampling method.The basic information and the relevant data of the risk factors for stroke of the subjects were collected and recorded completely.The subjects were divided into 3 groups according to their education levels from low to high.The relationship between their education levels and the risk factors for stroke were analyzed.Results A total of 633 staff members were enrolled,including 426 men (67.3％) and 207 women (32.7％).The low,middle and high education level groups were 188 (29.7％),193 (30.5％),and 252 (39.8％),respectively.With the increase of the education level,the prevalence of hypertension,dyslipidemia,and stroke decreased,and the awareness rates of hypertension and dyslipidemia and the treatment rate increased.The proportion of drink-ing increased in the male group and that decreased in the female group.The proportion of regular exercise increased in the female group.Multivariate logistic regression analysis showed that after adjusting for age,per capita income,employment,drinking,smoking,regular exercise and other factors,compared with the high education level group,the risk of hypertension increased 2.55 times in the low education level group in males (odds ratio [OR] 2.55,95％ confidence interval [CI] 1.42-4.58;P =0.002);the prevalence risk of dyslipidemia increased 2.25 (OR 2.25,95％ CI 1.31-3.86;P =0.003) and 2.02 times in the low and middle education level groups (OR 2.02,95％ CI 1.23-3.33;P =0.006) respectively;the risk of smoking decreased 42％ in the middle education level group (OR 0.58,95％ CI 0.36-0.93;P =0.024);the risk of hypertension increased 6.27 times in the low level education group in women (OR 6.27,95％ CI 1.59-24.74;P =0.009);the risk of dyslipidemia increased 3.91 times in the middle education level group (OR 3.91,95％ CI 1.70-8.98;P =0.001);the risk of drinking increased 3.49 times in the low level education group (OR 3.49,95％ CI 1.12-10.92;P =0.032),and the weekly regular exercise decreased 65％ in the low level education group (OR0.35,95％ CI0.15-0.82;P =0.016).Conclusion The incidence of the risk factors for stroke in the low education level group was higher than the popuhtions of high or middle education level.

Objective To explore the clinical value of microsurgery in the treatment of lateral ventricle tumors. Methods Microsurgery was conducted in 14 cases of lateral ventricle trmors in this department from May 1996 to August 2002. According to the location of tumors, we selected the approach close to the focus, protected the surrounding nerve tissue and the deep venous system, and resected the tumor in fractions. Results Among the 14 cases, 13 (92.9%) received total resection and 1 (7.1%) subtotal resection. A total of 11 cases of complications occurred postoperatively, including 3 cases of intracranial infection, 2 cases of hemiparalysis, 1 case of hydrocephalus, 3 cases of frontal lobe mental symptoms, 1 case of intraventricular hematoma and 1 case of nominal aphasia. Except for 1 case of hemiparalysis who were not able to resume the ability to take care of his own basic needs, the remaining 10 cases obtained full recovery. Follow-up in 9 cases for 6～60 months (mean, 29 months) showed 2 cases of recurrence of astrocytoma. Conclusions Microsurgery offers good visualization, minimal invasion and a high total resection rate for tumor.

Objective To investigate the clinical application value of stathmin, p16 and Ki-67 in the cervical intractable cases. Methods Immunohistochemical method was used to detect the expressions of stathmin, p16 and Ki-67 in surgical specimens of 288 cervical intractable cases, including 30 cases of cervical benign changes, 70 cases of cervical intraepithelial neoplasia (CIN)Ⅰ, 78 cases of CINⅡ, 85 cases of CINⅢand 25 cases of squamous cell carcinoma (SCC, as control group). The application value of stathmin, p16 and Ki-67 in the cervical cases were analyzed. Results The positive expression rates of Ki-67 of cervical benign changes and CINⅠwere 20.0 % (6/30) and 54.3 % (38/70) (χ2 = 3.29, P> 0.05). The expression rates of Ki-67 in CINⅡ, CINⅢ and SCC were all 100.0 %, and compared with the cervix benign changes, the differences were statistically significant (χ2= 112, P< 0.05). The expression rates of p16 in cervical benign changes and CINⅠwere 6.7 % (2/30) and 91.4 % (64/70), and there was significantly statistical difference (χ2=50.64, P<0.05). However, the expression rates of p16 in CINⅡ, CINⅢand SCC were all 100.0%, and compared with the cervix benign changes, the differences were statistically significant (χ2= 7.18, P< 0.01). The expression rates of stathmin in cervical benign changes, CINⅠ, CIN Ⅱ, CINⅢ and SCC were 3.3 %(1/30), 5.7 % (4/70), 23.1 % (18/78), 77.0 % (67/87) and 100.0 % (25/25), respectively, and there was no statistic difference in cervical benign changes, CINⅠand CINⅡ (χ2=0.68, P>0.05), but the expression rates in CINⅢ and SCC were higher than those in cervical benign change, CINⅠand CIN Ⅱ(P< 0.01). The positive expressions of stathmin, p16 and Ki-67 in each group of CIN were positively correlated (r= 0.412, P< 0.05). Conclusions Combined detection of p16 and Ki-67 can assist in the differential diagnosis of cervical intractable cases, and provide objective indicators for the classification and accurate diagnosis of CIN. Combined detection of p16 and stathmin may help to identify high-grade, low-grade CIN and cervix benign changes for the reduction of over-treatment.

Objective To investigate the clinical features of VAE and to assess the predictive value of VAE cough. Methods We retrospectively reviewed the medical records of 461 consecutive patients who underwent DBS surgery at Beijing Tiantan Hospital. Patients with VAE manifestation were enrolled in this study. The clinical features, operative courses, post-operative conditions and treatment of these patients were analyzed. The correlation between intraoperative tremor intensity , cough duration and prognosis was also investigated. Results Among 461 patients,10 (2.2%) were found with evidence of VAE, including cough, dyspnea, decreased O2 saturation (SO2). Statistical analyses revealed that severe cough was associated with greater age , a longer coughing time, more intensive tremor, greater influence, and a longer length of stay (P < 0.05, rspectively). Conclusions Early recognition and prompt management of VAE are essential to prevent unfavorable consequences. Cough intensity might be a useful tool for evaluating VAE and its prognosis , which is helpful for neurosurgeons to decide on the subsequent maneuvers.