1.Expression of CCL26 in esophageal squamous cell carcinoma tissues and its clinical significance
Xiaodong YANG ; Junjing QIAO ; Yanru QIN
China Oncology 2015;(1):13-18
Background and purpose: Chemokines play an important role in cancer occurrence and development. However, little about the function of CCL26 in esophageal squamous cell carcinoma (ESCC) is reported. This study was designed to observe and study the expression of chemokine CCL26 in ESCC tissues and to analyze their association with pathological features of ESCC. Methods: Expressions of chemokine CCL26 in 197 ESCC tissues and their corresponding paraneoplastic normal esophageal tissues were determined by tissue array and immunohistochemistry (IHC) technique, and its correlations to age, gender, lymph nodes metastasis, TNM stage, general classification and 5-year survival rate of ESCC patients were further analyzed. Results: ①CCL26 was expressed in both ESCC and paraneoplastic normal esophageal tissues. The expression of CCL26 in ESCC tissues was signiifcantly higher than that in paraneoplastic normal esophageal tissues (61.8%vs 20.6%, P<0.05).②The expression of CCL26 was correlated with lymph node metastasis, but not correlated with age, gender, tumor cell differentiation, and general classiifcation (P>0.05).③Survival analysis showed that the abnormal expression of CCL26 was associated with 5-year survival rate of patients with ESCC. The 5-year survival rate of ESCC patients with CCL26 positive expression was obviously lower than that of ESCC patients with CCL26 negative expression. Conclusion: CCL26 upexpression might play an important role in the progression and development of ESCC patients. The high level of CCL26 expression is correlated with lymph node metastasis and poor survival. Detection of CCL26 expression may have important prognostic values in ESCC patients.
2.Teaching practice of basic surgical skills training
Jianliang QIAO ; Junjing ZHANG ; Jianjun REN ; Junhua JIN ; Xingkai MENG
Chinese Journal of Medical Education Research 2015;(1):46-48
Basic surgical skills tralning which belongs to the basic course of surgery, is clini-cal basis for the medical students. The teaching practice of basic surgical skills tralning was explored by the Affiliated Hospital of Inner Mongolia Medical University, the theoretical teaching was combined with skills tralning practice, three kinds of means which contalned the model, animal tissues and or-gans in vitro and animal experiment were used to carry out systemic and standardized tralning. Finally, the basic surgical skills of postgraduate in surgery were improved, and the expected alm of teaching was achieved.
3.Esophagofundostomy in combination with esophagogastric devascularization for the treatment of portal hypertension
Zhiyong WANG ; Junjing ZHANG ; Jianliang QIAO ; Xingkai MENG
Chinese Journal of General Surgery 2014;29(11):828-830
Objective To evaluate the effect of esophagofundostomy combined with devascularization for the treatment of portal hypertension.Methods From February 2009 to August 2013,30 cases (research group) underwent esophagofundostomy combined with devascularization,while 56 cases (control group) were treated by devascularization only.Splenectomy was performed in all patients.Results There was no perioperative mortality in either group.The difference of postoperative serum bilirubin,albumin and blood platelet was not statistically significant (t =1.13、0.23、1.53,all P > 0.05) ; The incidence of hepatic encephalopathy in research group and control group was 3% and 11%,respectively,three years mortality was 14% and 24%,respectively (x2 =0.61、1.22,all P >0.05).The rebleeding rate in research group was lower than control group,there was a significant difference (x2 =4.61,P < 0.05).Research group was superior to control group in improving esophageal-gastric varices and there was a significant difference (P < 0.05).Conclusions Compared with devascularization,esophagofundostomy combined with devascularization is more effective in reducing esophageal-gastric varices and prevention of rebleeding.
4.Updates of heterotopic auxiliary liver transplantation with portal vein arterialization
Jun LI ; Jianjun REN ; Junjing ZHANG ; Jianliang QIAO ; Xingkai MENG
Chinese Journal of Digestive Surgery 2015;14(9):777-780
In recent years,liver transplantation donor shortage as one of world medical problems is paid more attention by domestic and overseas scholars.In view of that,heterotopic auxiliary liver transplantation emerges which transplants the whole or some parts of a donor liver outside the original liver position on the condition that some parts or the whole of the original liver were retained.As for the liver transplantation with poor conditions on portal vein,reconstruction of portal vein has become an aporia.Based on this,some scholars put forward the theory——arterialization of portal vein(PVA),namely a method to increase arterial blood supply or replace portal vein blood perfusion of liver by establishing some pathes among artery and portal vein or its branches.The research background and current situation of heterotopic auxiliary liver transplantation with portal vein arterialization,the transplanting position of donor liver,vessel reconstruction,dynamics mechanism after reconstruction and liver regene-ration are summarized in this review.
5.Multi-slice CT for preoperative assessment in living donor
Junjing ZHANG ; Xingkai MENG ; Dapeng WANG ; Jianjun REN ; Jianliang QIAO ; Dexi LI ; Bingbing WU ; Yong WANG
International Journal of Surgery 2009;36(6):415-418
Radiological evaluation is a key step for donor's preoperative evaluation in living donor liver transplantation(LDLT).There are many powerful functions in multi-slice computed tomography (MSCT)which can suit all-in-one radiological evaluation before donor's operation.By referring to the articles from home and abroad in recent years,from viewpoint of surgeon,this artical reviews the application status of multi-slice CT for preoperative assessment in LDLT,which can help to provide theory support for choice of radiological examination in LDLT donor.
6.Significance of peritoneal effusion detection by emergency ultrasound in closed abdominal injury
Bingbing WU ; Dexi LI ; Zhou YANG ; Jianliang QIAO ; Junquan ZHENG ; Yong WANG ; Qi WANG ; Fuyong TAN ; Feifei LV ; Junjing ZHANG
Chinese Journal of Postgraduates of Medicine 2010;33(8):20-21
Objective To discuss the diagnostic value of peritoneal effusion detection by emergency-ultrasound in patients with closed abdominal injury. Method From August 2006 to June 2009,212 patients with closed abdominal injury were studied to evaluate peritoneal effusion detection by emergency ultrasound. Results of 212 patients,peritoneal effusion frequency rate was 78.8%( 167/212), meanwhile,abdominal paracentesis confirmation ratio was only 46.2%(98/212). In the follow-up, 13 patients with injuried hollow viscera and 1 patient with rupture of kidney showed peritoneal effusion. The volume of abdominal fluid was increasing in 17 patients,which needed to be managed by surgery. The accuracy rates were respectively 78.3%( 112/143) and 36.1%(13/36) in the solid organs and the hollow organs. Conclusion During the course of diagnosis and treatment in closed abdominal injury,peritoneal effusion monitoring by ultrasound should be used routinely, which can help to decrease the rate of misdiagnosis and avoid delayed treatment.