Objective To investigate the difference of serum levels of cystatin C and its gene polymorphism of patients with CHD and normal people between Zhuang and Han in Guanxi region.Methyds The levels of serum cystatin C in Zhuang CHD patients,Han CHD patients,Zhuang normal people and Han normal people(each of 100 cases)were detected by Immunoturbidimetric Assays,Cys C + 148 and Cys C-82 genotypes were conducted by using PCR-RFLP,and that data and clinical data were analyzed.Results The difference of Cys C levels and clinical data between two CHD groups and two normal groups were statically significant (all P＜0.05).①The Cys C levels of two CHD groups was not statically significant difference (P=0.156).②The CysC+148 and Cys C-82 of 4 groups conform the Hardy-Weinberg population genetic equilibrium law (all P＞0.05).The genotypes frequency difference of Cys C+148 and Cys C-82 between two CHD groups and two normal group were no statically significant (x2 =0.760～2.090,P＞0.05).③The serum Cys C level and Cr of CHD group were positively correlated (r=0.597,P＜0.001).Conclusion The correlation Cys C+ 148,-82 polymorphism and Guangxi Zhuang CHD were in need of further study,but the kidney damage caused by the high serum Cys C level may be a risk factor for Guangxi Zhuang and Han CHD patients.

Objective To investigate the correlation of cystatin C(Cys C) serum level and its gene polymorphism among Zhuang population with Metabolic Syndrome(MS) of Guangxi district.Methods The levels of serum Cys C in Zhuang MS patients,Han MS patients,Zhuang normal people and Han normal people(each of 100 cases)were detected by Immunoturbidimetric Assays.Cys C +148,Cys C+73 and Cys C-82 genotyping were conducted by using PCR-RFLP.Results The clinical data and serum Cys C levels of four groups were significantly different(P＜0.05),The clinical data and serum Cys C levels of two CHD groups were significantly different from those in the two normal groups(P＜0.05);(2) There was a positive correlation between Cys C levels and creatinine(Cr) level in peripheral blood(r=0.551,P=0.000);(3) There was no significant difference in the genotype frequencies of Cys C+73,Cys C+ 148 and Cys C-82 in 4 groups(x2 =3.139,0.791;x2 =4.841,P=0.564;x2 =3.207,P=0.782);(4)Cys C level in MS patients of Cys C+73 GG genotype was significantly lower than that of AG and AA genotype,and the difference was statistically significant (P ＜ 0.05).But there was no significant difference in Cys C level between AG type and AA type.Conclusion The high level of Cys C caused by impaired renal function may be a risk factor for MS patients in Zhuang and Han population in Guangxi.Cys C+73 locus gene polymorphism and the relationship between MS patients in Guangxi Zhuang population need further study.

Objective To investigate the correlations of serum cystatin C levels,cystatin C gene + 148 and + 73 polymorphism and metabolic syndrome (MS) of Chinese Zhuang and Han population in Guangxi region.Methods A hundred MS patients and healthy individuals for each group of Zhuang and Han population were selected in this study.Serum cystatin C levels were determined by immunoturbidimetric assay.Gene polymorphism of CysC + 148 and + 73 were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).The correlations between serum CysC level,CysC gene polymorphism and MS in Zhuang and Han population were analized.Results There were significant differences of serum CysC levels between the two MS groups and healthy controls group (all P ＜ 0.05),but no significant difference of the genotype frequencies of CysC + 73 and CysC + 148 in the four groups was observed (x2 =3.139,P =0.791;x2 =4.841,P =0.564).The serum Cys C levels of CysC + 73 GG genotype in both MS groups were lower than those of CysC + 73 AG and AA genotype with statistically significant differences (all P ＜ 0.05).The serum Cys C levels in MS groups were correlated with serum creatinine levels (P ＜ 0.01) and CysC + 73 gene polymorphism (P ＜ 0.01).Conclusion The serum Cys C level of the MS patients in Zhuang and Han population may vary with the genotype of CysC + 73 genetic variant,and associate with serum creatinine level.

Objective:To describe a systematic approach on identification of poisonous mushroom by investigating two cases of Omphalotus guepiniformis poisoning in Jianyang district, Nanping, Fujian province. Methods:Two incidents of food poisoning on 10 migrant workers were investigated. The remaining suspected mushroom samples were collected and the same fresh mushroom specimens were also collected in the following field investigations from the same dead tree and fallen trunk. These mushroom specimens were identified based on morphological and phylogenetic analyses.Results:On November 24 and 26, 2018, 8 and 2 migrant workers from Jianyang District, Nanping ate wild mushrooms and developed acute nausea, vomiting, abdominal pain and other symptoms within 10 to 90 min after consumption. They were diagnosed as mushroom poisoning, with gastroenteritis as the main manifestation. Further analysis showed that the more poisonous mushroom were consumed, the shorter latency and longer duration of nausea and vomiting were resulted. After admission, gastric lavage, catharsis, acid preparation, gastric protection, fluid replenishment and other symptomatic support treatments were given in time, all patients were discharged in 1-3 d. Based on morphological and phylogenetic analyses, the samples were identified as O. guepiniformis. Conclusions:The two incidents were caused by accidental consumption of O. guepiniformis. Awareness education about poisonous mushroom should be provided to migrant workers to prevent more such poisoning incidents in the future.

OBJECTIVE: To evaluate the effect of health self-management on self-efficiency of diabetes patients.
 METHODS: A total of 184 eligible and voluntary diabetes patients were recruited for 6 consecutive weeks of knowledge and skills intervention, and interviewed with questionnaire by diabetes self-efficacy scale (DSES) before and after the intervention. The changes in self-efficiency were compared with two paired sample McNemar test.
 RESULTS: After the intervention, the total scores of self-efficiency on diet, medication, blood sugar monitoring, foot care and complications management were all increased significantly compared with those before the intervention (P<0.05).
 CONCLUSION The intervention model of health self-management for self-efficiency in diabetes patients is effective, and the quality of patients' life can be improved.
Diabetes Mellitus ; psychology ; therapy ; Disease Management ; Humans ; Self Care ; Self Efficacy ; Surveys and Questionnaires