An anaphylactic reaction is a most severe immune-mediated reaction. Diclofenac is a widely used non-steroidal anti-inflammatory drug (NSAID) derivative of phenylacetic acid, and continues to be routinely prescribed. We report a case of an anaphylactic reaction induced by oral diclofenac.

We report a rare case of trigeminovagal reflex (TVR) resulting from stimulation of the mandibular division of the trigeminal nerve under general anesthesia. Although general anesthesia reportedly prevents TVR, it should be part of the differential diagnosis in all cases of unexplained sinus arrest during oral and maxillofacial surgery.