Objective:To compare influence of Cushing's syndrome and essential hypertension (EH)on metabolic in-dexes.Methods:A total of 22 pathologically confirmed patients With Cushing's syndrome Were regarded as Cushing group and 22 EH patients,Who admitted in the same period With matched age,gender,nationality,body mass index (BMI)and mean blood pressure level for Cushing group,Were enrolled as EH group.Fasting blood glucose (FBG), 2h postprandial blood glucose (2hPBG),fasting insulin (FINS),2h postprandial insulin (2hINS),homeostasis mod-el-insulin resistance index (HOMA-IR),total cholesterol (TC),triglyceride (TG)and high density lipoprotein cho-lesterol (HDL-C)etc.Were compared betWeen tWo groups,and they Were statistically analyzed.Results:Com-pared With EH group,there Were significant increase in FBG [(4.75±0.44)mmol/L vs.(6.31±0.51)mmol/L], FINS [(13.04±2.68)mU/L vs.(29.05±2.92)mU/L],2hPBG [(7.32±0.82)mmol/L vs.(8.96±1.14)mmol/L],2hINS [(37.66±9.21)mU/L vs.(104.45±23.14)mU/L],HOMA-IR [(2.57±0.44)vs.(7.96±0.56)], TC [(4.15±0.93)mmol/L vs.(5.17±1.35)mmol/L]and TG [(1.44±0.87)mmol/L vs.(2.24±1.25)mmol/L]in Cushing group,P<0.05 or<0.01.Conclusion:Compared With essential hypertension,there are more meta-bolic changes and more obvious insulin resistance in Cushing's syndrome.

Objective:To investigate the anti-inflammatory and analgesic effects of Zhonghua Dieda Pills; To preliminarily explore its mechanism on adjuvant arthritis model rats.Methods:Three inflammatory models and two pain models were used to investigate the anti-inflammatory and analgesic effects of Zhonghua Dieda Pills. After establishing the adjuvant arthritis rat model, the rats were divided into normal group, model group, dexamethasone group (0.8 mg/kg), and Zhonghua Dieda Pills (2.0, 1.0, 0.5 g/kg) groups according to random number table method. Each group was given corresponding drugs once a day for 5 weeks. The toe volume was measured at 1, 3 and 5 weeks after administration, and the swelling degree was calculated; the organ indices of rats were calculated and the histopathological changes of articular cartilage were observed by HE staining; the expressions of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and transforming growth factor-β (TGF-β) in joint tissues were detected by immunohistochemistry.Results:Zhonghua Dieda Pills (2.0 g/kg) group significantly reduced the swelling of foot and plantar of rats, reduced the swelling of ear of mice, and reduced the dry weight of granuloma of rats ( P<0.05); Zhonghua Dieda Pills (1.4 g/kg) group significantly reduced the number of twisting of rats, and the pain threshold after 3 h of administration was significantly higher than that of the control group ( P<0.05); Zhonghua Dieda Pills (2.0 g/kg) group significantly reduced the swelling of the foot and metatarsal of arthritic rats after 3-5 weeks of administration ( P<0.05), decreased the thymus index ( P<0.05), and reduced the expression levels of IL-1β, TNF-α and TGF-β in joint tissues ( P<0.05). Conclusion:Zhonghua Dieda Pills have confirmed anti-inflammatory and analgesic effects, which may play a therapeutic role in adjuvant arthritis model rats by reducing the levels of inflammatory factors such as IL-1β, TNF-α and TGF-β.