OBJECTIVE:To establish a method for separation and determination of ethanol,dichloromethane and N,N-dimethylformamide in pidotimod tablets.METHODS:The residual organic solvents were quantitatively determined by GC on DB-624 capillary column with FID detector,using nitrogen as the carries gas.Temperature programming was carried out in which the column temperature was initially maintained at 40 ℃ for 5 minutes,then increased at a rate of 50 ℃ per minute to 200 ℃,and maintained at 200 ℃ for at least 10 minutes.The temperature at injection mouth was maintained at 160 ℃;the detector temperature was maintained at 280 ℃.The split ratio was 5∶1.RESULTS:3 residual organic solvents were completely separated and their determination was free of inference from hidden foreign substances.The linear ranges of the ethanol,dichloromethane and N,N-dimethylformamide were 10.036～802.88 (r=0.999 9),26.44～105.76 (r=0.999 6),and 1.76～140.8 (r=0.999 5) ?g?mL-1,respectively,and their average recovery rates were 102.4%,99.0%,and 99.2%,respectively,with RSD at 1.99%,3.34%,and 0.55%,respectively.CONCLUSION:The method is sensitive,accurate and rapid,and it is suitable for determination of residual organic solvents in pidotimod tablets.

Objective To analysis of treadmill exercise test Duke score(DTS) in patients with coronary heart disease than the evaluation functions of heart operation perioperative cardiac events.Methods One hundred and eighty-four patients with coronary heart disease,45 ～ 75 years of medium-sized non cardiac operation,were chose from May,2010 to May,2011 in our hospital,Cardiac ultrasound,treadmill exercise test were taken before operation,preoperative examination department of internal medicine disease history and physical examinations.According to the Duke score,they were divided into DTS in low risk group (5 ≤ Duke ≤ 15,n =124),medium risk group DTS(DTS:(-10≤Duke≤5,n =60),the exclusions of patients with high-risk DTS group,and the high-risk group of patients were excluded.Comparative analysis of operations,the main type of Department of internal medicine disease history,intraoperative and postoperative major cardiovascular complications.Results In the two groups of operation type and the type of anesthesia and cardiovascular disease,there is no significant difference (P ＞ 0.05) ; in DTS low risk group the age (59.2 ± 4.1) years,preoperative cardiac dysfunction were 2 cases,left ventricular ejection fraction ＜ 0.50 were 2 case (1.6％),diabetes history 12 case(9.6％),with angina pectoris symptoms of 51 case(41.1％),ECG ischemic changes in 55 (44.3 ％),in the medium DTS risk group,the age(65.2 ± 2.6)years,preoperative cardiac dysfunction were 8 cases(13.3％),left ventricular ejection fraction of ＜ 0.50 was 5 case (8.3％),diabetes history 23 case (38.3 ％),angina pectoris and 60 case (100％),ECG ischemic changes in 40 case (66.7 ％) (t =2.98,P =0.042,x2 values were 4.93,3.84,4.67,5.24,3.58,P ＜0.05).The low risk group of patients with arrhythmia,hypertension incidence rate were 6.5％ (8/124) and 22.5％ (28/124),medium risk group of patients with arrhythmia,hypertension incidence rate were 11.6％ (7/60) and 18.3％ (11/60),compared with DTS in low risk group,DTS medium risk group of arrhythmia and hypertension odds ratio(Odds Ratio,OR) and 95％ confidence intervals were 1.7 (0.8-3.3),0.8 (0.4-1.4),the P values were 0.062,0.074,has no significant difference.Controlling for age and sex DTS in low risk group postoperative myocardial infarction,cardiogenic pulmonary edema rate were 0.8％ (1/124) and 2.4％ (3/124),medium risk group after DTS myocardial infarction,cardiogenic pulmonary edema rate were 10％ (6/60) and 11.7％ (7/60),compared with DTS in low risk group,DTS medium risk group after myocardial infarction and heart pulmonary edema ratios (Odds Ratio,OR) and 95％ confidence intervals were 19.3 (5.6-66.2),5.7 (2.5-12.9),the P values were 0.002,0.003,had significant diflerence.Conclusion DTS medium risk group patients undergoing non cardiac operation preoperative heart failure,diabetes,angina symptoms,peri operation period of cardiac event rate is high and heavy.

The Holy Bible, as the root of Western civilization, has imposed great influence in the fields far beyond religion. In this thesis, the author intended to reveal the medical implication in the Holy Bible and its relevance to the modern medical science by exploring the biblical medical information and comparing it with the current medical theory and practice. The conclusion of the exploration is surprising yet inspiring: the Holy Bible, as an ancient religious book, contains rich medical information around themes such as sexual relations, dietary guidelines, hygiene, etc., which is not at odds, but in harmony with the modern medicine.

EBP50(ERM-binding phosphoprotein-50),a multifunctional adapter protein with 358 amino acids and two PDZ domains, regulates cell growth and migration. Lines of evidences indicate that it is a potential cancer suppressor protein. Loss of heterozygosity (LOH) and intragenic mutation of the ebp50 gene have been found in both primary breast tumors and breast cancer cell lines. EBP50 suppresses the breast cancer cell proliferation via its interaction with many tumor suppressor protein including PTEN, SYK, MERLIN, etc. Here the molecular structure of EBP50, signal pathway regulated by EBP50, and the relationship between breast cancer development and EBP50 are discussed.

Radiotherapy is one of the most important treatments for glioma; however its therapeutic effect is unsatisfying. Timing, accurate target outlining, a total dose higher than 60Gy, conformal modulating radiotherapy and combined chemotherapy and targeted therapy are important factors in improving the outcome of radiotherapy.

Objective To find out the prevalence of iodine deficiency disorders (IDD) and population iodine nutritional status,and to evaluate the intervention effect of iodized salt during the Twelfth Five-Year Plan period,and to provide a scientific basis for adjusting the intervention programs.Methods One town was selected respectively from the east,the west,the south,the north and the central of the entire city,4 villages were selected from each town,15 residents were selected to determine iodide content by quantitative detection;1 primary school was selected respectively from those 5 chosen towns,40 subjects aged from 8 to 10 years old (half male and half female) in each school were selected to collect urine samples for determination of urinary iodine,and to detect the volume of thyroid by palpation;20 pregnant women were chosen respectively from those 5 towns to detect their urinary iodine content and to determine iodine content of their salt samples,10 pregnant women were selected to investigate their healthy knowledge.Results A total of 300 samples of edible salt were tested,the median of salt iodine was 21.2 mg/kg,coverage rate of iodized salt was 97.7％ (293/300),the consumption rate of eligible iodized salt at household level was 90.3％ (271/300);the median of urinary iodine level was 232.4 μg/L in 200 8-10 years old chindren;232.9 μg/L in 100 pregnant women;the prevalence rate of goiter in children aged 8-10 was 3.0％ (6/200);the healthy knowledge rate of pregnant women was 82.0％ (41/50).Conclusions During the Twelfth Five-Year Plan period,Zaoyang has achieved the stage of elimination of IDD,but the situation of iodine nutritionrich children and the iodine nutrition-lack pregnant women are still exist.Therefore,we still need to strengthen the salt market management and insist to spread the knowledge of IDD,to eliminate the non-iodized salt from the market,and to ensure all people in appropriate iodine nutrition.

Objective To investigate the emotional intelligence training training's impact on medical students' ethics education.Methods Givingnthe undergraduate and graduate students of Grade 2009,2010 and 2011 emotional intelligent training and distributing questionnaires on ethics education and comparing the result with that of 2006,2007,2008 undergraduate and graduates.Covering issues of medical ethics and the understanding of students' role in alleviating the doctor-patient relationship in medical ethics,evaluation of medical ethics in today's society,the doctor of professional ethics,medical ethics education approaches and problems and so on.By comparing the results of the questionnaire students' knowledge of medical ethics are evaluated and their emotional intelligence training in ethics education role are analyzed.Research data for entry to a database of Excel 2013,using SPSS 19.0 statistical software for analysis,count data taken x2 test,P＜0.05 was considered statistically significant.According to the questionnaire topic A representative proportion of medical students is selected to measure the level of ethics and the role of ethics education in medical students training in emotional intelligence.Results the students of 2006,2007 and 2008 who selected A of five topics were 54.78％(1 278/2 333),79.47％(1 854/2 333),68.41％(1 596/2 333),86.28％(2 013/ 2 333),13.12％(306/2 333); while the students of 2009,2010 and 2011 who selected A of five topics were 73.70％(1 777/2 411),88.68％(2 138/2 411),81.54％(1 966/2 411),93.78％(2 261/2 411),71.75％(1 730/2 411).The difference was statistically significant,indicating that 2009,2010 and 2011 medical students' cognitive level of ethicshas been nore significantly improved than the students of Grade 2006,2007 and 2008.Conclusion EQ training can significantly improve the effectiveness of medical ethics education for medical students and it is worth promoting.

Objective To investigate the clinical effect ofFuzheng-Shugan decoction on the treatment of patients with the treatment nodule.Methods A total of 80 patients with thyroid nodule from Jan.2014 to Dec.2015, divided into two groups. The efficacy, thyroid stimulating hormone, high risk factors, the maximum diameter and volume of thyroid nodules were observed.Results The effective rate of observation group was significantly higher than of the control group (90.00%vs.27.50%,χ2=32.237,P=0.000). The shortness of breath (1.62 ± 0.86vs. 4.35 ± 1.13,t=12.159), foreign body sensation (2.53 ± 0.62vs. 4.23 ± 0.56,t=12.289), irritability (1.56 ± 0.53vs. 3.52 ± 1.25,t=9.130), sweating (1.85 ± 0.62vs.4.23 ± 0.56,t=18.017), tongue (1.58 ± 0.93vs. 3.71 ± 1.25,t=8.646) and neck pain (0.82 ± 0.35vs. 3.92 ± 0.65,t=26.558) in the obversation group were significantly lower than those in the control group (P<0.05). The thyroid stimulating hormone levels in the observation group (1.05 ± 0.21 mIU/Lvs. 2.16 ± 0.71 mIU/L,t=9.482), were significantly lower (P<0.05). The maximum diameter (8.52 ± 4.72 mmvs. 12.27 ± 5.69 mm,t=3.208) nodule volume (0.26 ± 0.71 cm3vs. 0.96 ± 1.02 cm3,t=3.562) and high risk factors (2.73 ± 1.45vs. 4.05 ± 1.36,t=4.199) in the observation group were significantly lower than those in the control group (P<0.05).Conclusion TheFuzheng-Shugan decoction can improve TCM syndrome, reduce the risk factors, and effectively reduce the nodule maximum diameter and volume.

During radiation for head and neck cancers,part of parotids are contained in planning target volume(PTV),which lead to parotids receiving radiation as the same as PTV.Radiation for head and neck cancers will influence the parotids.In the period of radiation,many factors will influence parotids,such as age,primary parotid volume,V10-40,weight and mean radiation dose et al.These factors will result in that the parotid volume reduces nearly 50％ and moves toward the middle line of the body.As a result,the real dose of the parotid receiving is higher than prescription dose.The excretion function of the parotid will be severely damaged after radiation,which will lead to xerostomia and influence the quality of patients life.

The application of 18 F-FDG PET-CT in the diagnosis and treatment of nasopharyngeal carcinoma includes early diagnosis,clinical staging,contouring target volume,predicting the sensitivity of tumors to radiotherapy and effect evaluation,and monitoring the residual and recurrence.However,18 F-FDG uptake of tumor cells is under the influence of various factors,so false positive and false negative are unavoidable.Therefore it is need to develop more specific tracer agent in order to improve the accuracy of diagnosis and treatment,as well as to carry out multicenter clinical trial to identify the correlation of standardized uptake value (SUV)and radiation target volume.