AIM To study the effects of No.1 Weiyan Decoction (Codonopsis Radix,Paeoniae Radix alba,Taraxaci Herba,etc.) on hypoxia and hypoxic tolerance in gastric mucosal epithelial cells in rats with precancerous lesion of gastric cancer (PLGC).METHODS Forty rats were randomly divided into normal,model,Vitacoenzyme Tablets and No.1 Weiyan Decoction groups.Except for the normal group,the rats in the other groups were given with N-methyl-N'-nitro-N-nitrosoguanidine and Little Chengqi Decoction to establish a PLGC rat model.Ten weeks after the administration,the gastric mucosal epithelial microvascular ultrastructure was observed,the expressions of Hif1a mRNA,HIF-1 α protein and VEGF protein in gastric mucosal epithelium were detected.RESULTS Compared with the normal group,the number of microvasculatures in gastric mucosal epithelium was decreased;lumen was severely stenosed or expansive;inner wall was not smooth and had adhesion;vascular endothelial cells were swollen;the expression of Hif1α mRNA showed an increasing trend;the expressions of HIF-1α protein and VEGF protein were anomalous in the model group.Compared with the model group,the gastric mucosal vascular lesion of PLGC rats was improved,and the expressions of Hif1a mRNA,HIF-1α protein and VEGF protein were significantly decreased in the No.1 Weiyan Decoction group.CONCLUSION No.1 Weiyan Decoction can improve hypoxia and hypoxia tolerance,and induce angiogenesis in gastric mucosal epithelium in PLGC rats.

Objective: To investigate the risk factors of suicide attempt and offer the prevention measures.Methods: This study collected the suicide attempters from 10 county hospitals through the hospital emergency and patient registration system in Shandong province from 2013-2015, and community control for the case was selected matched with community, gender, age (± 2 years). Questionnaire was used to collect data. The univariate statistical methods were adopted to preliminarily screen the influencing factors, and multivariate Logistic regression analysis was used to establish the model. Results: There were 424 cases including148 (34. 9％) males and 276 (65. 1％) females, 434 controls including 158 (36. 4％) males and 276 (63. 6％) females. Univariate and multivariate analysis both indicated that mental illness, poorer family economic status, poorer conjugal relationship, family history of attempted suicide, worse social relationships and poorer individual education opportunity were the risk factors of suicide attempt, but larger family member was the protective factor for the suicide attempts. Conclusion: Preventive measures should be taken to reduce suicide attempts.