Objective To explore the relationship between the neighborhood environment and the residents' suicidal risk and provide evidence for suicide prevention.Methods The study sample consisted of 392young suicides (aged 15-34 years) and 416 community living controls from the same areas of China (randomly selected from 16 rural counties in three provinces).Social factors in the village neighborhoods were measured by the WHO SUPRE-MISS scale of Community Stress and Problems.Psychological autopsy methods and multivariable Logistic regression were employed.Two informants were interviewed to collect the information of each subject.Results It was found that there was positive correlation between the community surrounding score and suicide.The community stress and problems was the main risk factor for suicide(Wald x2 =10.036,P＜0.05,OR=1.323).Family disputes,inconvenience transportation,lack of health care and job security,alcohol abuse,and superstition can increase the suicidal risks among rural young Chinese.It was still indicated that relative poverty,suffering from a mental illness(OR=32.346) were the risk factors; but good education,married and good health were the protective factors for suicide.Conclusion Further improving the social assistance system,solving the existing community stress and problems,building better community environment are needed to reduce the stress of community residents.Psychological screening and the community mental health intervention for high-risk groups should be strengthened to improve residents' response capacity to stress.Those measures can reduce the suicide rate of China rural community residents effectively.

Objective: To investigate the risk factors of suicide attempt and offer the prevention measures.Methods: This study collected the suicide attempters from 10 county hospitals through the hospital emergency and patient registration system in Shandong province from 2013-2015, and community control for the case was selected matched with community, gender, age (± 2 years). Questionnaire was used to collect data. The univariate statistical methods were adopted to preliminarily screen the influencing factors, and multivariate Logistic regression analysis was used to establish the model. Results: There were 424 cases including148 (34. 9％) males and 276 (65. 1％) females, 434 controls including 158 (36. 4％) males and 276 (63. 6％) females. Univariate and multivariate analysis both indicated that mental illness, poorer family economic status, poorer conjugal relationship, family history of attempted suicide, worse social relationships and poorer individual education opportunity were the risk factors of suicide attempt, but larger family member was the protective factor for the suicide attempts. Conclusion: Preventive measures should be taken to reduce suicide attempts.

Candida albicans is one of the most common species of Candida, which is an important cause of invasive candidiasis in clinic. Due to the frequently use of classical antifungal agents, there are amounts of drug resistant C. albicans being isolated, causing the significantly decreasing of the efficacy of some antifungal agents in clinical treatment. Besides, the use of some compounds in clinic has been limited because of their toxicities. In such a context, drug combination therapy shows great potential on antifungal because of the synergy of different drugs or therapeutic methods that could bring, which could improve the weaknesses of single drug.