0.05). Genotype B+C(2.93?0.74 and 2.95?0.71) was associated with higher grade of necroinflammation and stage of fibrosis than genotype B(1.76?1.18 and 1.76?1.15 ) and C (1.93?1.32 and 1.84?1.29) HBV. Conclusions[KG1]genotype C or B+C HBV are associated with more severe liver damage in patients. Stratification for HBV genotypes should be considered in the antiviral treatment of chronic hepatitis B.