Objective To evaluate the clinical effectiveness of heat-sensitive moxibustion for knee osteoarthritis ( KOA) by systematic evaluation and Meta analysis methods. Methods Electronic information retrieval combined manual retrieval methods were used for collecting clinical randomized control trial of heat-sensitive moxibustion for KOA. The systematic evaluation was conducted by two individual researcher following the principles of Cochrane Review Handbook 5.1, and RevMan5.0 software was applied for the statistical analysis. Results Fifteen randomized controlled trials (RCT) were enrolled into the analysis, which involved 1228 cases. The results of systematic evaluation showed that the quality of most of the enrolled RCT were not so high. The results of Meta analysis were as follows: ( 1) Between heat-sensitive moxibustion and traditional moxibustion, the weighted mean difference (WMD) and 95%confidence index (CI) were-1.76, [-2.33, -1.18] for visual analog scale ( VAS) scores ( P<0.001) , were -2.36, [-3.42, -1.30] for the scores of guiding principle of clinical research on new drugs ( GPCRND) for KOA ( GPCRND-KOA) ( P<0.001) , and were 13.61, [7.60, -19.61]for Lysholm knee joint function scores (P<0.001), respectively; (2) Between heat-sensitive moxibustion and acupuncture, WMD and 95%CI were 6.19, [ 0.01, 11.37] for Lysholm scores ( P<0.05);(3) Between heat-sensitive moxibustion and warm-needling acupuncture, WMD and 95%CI were -10.14, [-17.47, -2.81] for the Western Ontario and McMaster Universities ( WOMAC) osteoarthritis index scores ( P<0.05). Conclusion It is indicated that heat-sensitive moxibustion shows certain therapeutic effect for knee osteoarthritis, better than traditional moxibustion.

OBJECTIVE:To observe the efficacy and safety of vitamin A acid combined with vitamin A,vitamin E,celecoxib in the treatment of oral leukoplakia. METHODS:104 patients with oral leukoplakia were randomly divided into control group(52 cases) and observation group (52 cases). Control group received 1 Vitamin A soft capsule,3 times a day+1 Vitamin E soft cap-sule,3 times a day+1 Celecoxib capsule,twice a day. Observation group additionally received 1 Vitamin A acid tablet,twice a day. 4-week was regarded as 1 treatment course,it lasted for 3 courses. Clinical efficacy,and leukoplakia number,maximum diam-eter of leukoplakia,immunoglobulin A(IgA),IgM,IgG before and after treatment,and the incidence of adverse reactions in 2 groups were observed. RESULTS:The total effective rate in observation group was significantly higher than control group,the dif-ference was statistically significant(P<0.05). Before treatment,there were no significant differences in leukoplakia number,maxi-mum diameter of leukoplakia,immunoglobulin levels in 2 groups(P>0.05). After treatment,leukoplakia number,maximum diam-eter of leukoplakia,IgA and IgM in 2 groups were significantly lower than before,and observation group was lower than control group,IgG was significantly higher than before,and observation group was higher than control group,the differences were statisti-cally significant (P<0.05). And there was no significant difference in the incidence of adverse reactions in 2 groups (P>0.05). CONCLUSIONS:Vitamin A acid combined with vitamin A,vitamin E,celecoxib shows obvious efficacy in the treatment of oral leukoplakia,it can effectively reduce clinical symptoms,improve immune function,with good safety.

Objective To explore the correlation factors of hospital stay and hospitalization costs among patients with acute ischemia stroke (AIS). Methods The clinical data of the patients with first diagnosis of AIS at Peking University Third Hospital in China from January 1 , 2012 to December 31 , 2012 were retrospectively analyzed to investigate the correlation factors of hospital stay and hospitalization costs using univariate analysis and multiple regression analysis. Results The study involved 496 patients, with a mean age of 63.38 years (range:26~88 years). Multivariate regression analysis showed the significant impact factors for LOS were age, pneumonia, the total score on NIHSS, medication for secondary prevention and stroke subtype. The significant impact factors for cost of hospital stay were payment method, stroke subtype, age, the total score on NIHSS and medication for secondary prevention. Conclusions Age, pneumonia, the total score on NIHSS, stroke treatment and its subtypes are the significant impact factors affecting hospital stay. Payment method, stroke subtype, age, the total score on NIHSS and medication for secondary prevention are the significant impact factors affecting costs of hospitalization.

[Objective]To investigate the effective method for allergic rhinitis.[Method]58 cases were randomly divided into 2 groups,treatment group 31 take self-made Yiqi Tuomin Decoction,other group 27 take cetirizine hydrochloride.[Result]In treatment group,16 cases had marked effect,12 had effect,3 had no effect,effective rate was 90.3%;for control one,they were 8,10,9 and 66.7%respectively.[Conclusion]Yiqi Tuomin Decoction has obvious effect on allergic rhinitis.

BACKGROUND:In some clinical applications or special work conditions,extremely intonse 50 Hz AC intefference exists.As the amplifier's output reaches or is close to saturation,it cannot be suppressed by general anti-interference circuits or software algorithms.Themfore,the hardware circuit must be impreved to suppress this interference,thus obtajning the desired signals.OBJECTIVE:To introduce a biopotential amplifier,which can effectively suppress the impact of 50 Hz AC interference on the weak biomedical signals.DESIGN:Create a circuit model based on the advanced theoretical analysis,then make software emulation and finally design the actual circuit implementation.SETTINGS:the 305 Hospital of Chinese PLA:Institute of Aviation Medicine,Air Force of CIIinese PLA.MATERIALS:The experimentaIinstruments and analytical software were provided by the Institute of Aviation Medicine,Air Force of Chinese PLA:the high-voltage electrical field environment was provided by the 305 Hospital of Chinese PLA.METHODS:The first step was theoretical analysis at the Institute of Aviation Medicine,Air Force of Chinese PLA in 2005,then the 50 Hz anti-reference model was created.After that,the following three anti-reference measures were put forward:①Enhancing the common-mode input impedance of the overall circuit to remove the interference caused by the imbalance electrode impedance;②reducing the equivalent common mode input impedance of the instrument amplifier in the circuit by using a current source controlled by the comlnou mode voltage;③using the driven-right-leg circuit to reduce the common mode voltage.Moreover,emulation analysis was made for the above circuit model by using the circuit emulation software TINA PRO.Through ceaseless improvement of the circuit model,the correct emulation results were obtained.In 2006,the Circuit model helped us realize the electrocardiogram(ECG)amplifier that could suppress the 50 Hz AC intefference effectively in intense interference environments.And that amplifier was put into practical use in the high-voltage electrical field environment produced by the high-voltage electrical field treatment equipment in the 305 Hospital of PLA.The result was satisfying:the 50 Hz AC interference was suppressed effectively and the high-quality ECG signals were obtained.MlAIN OUTCOME MEASURES:Common-Mode Rejection Ratio(CMRR)and the frequency spectrum of signals obtained in intense intefference environment,which are used to assess the ability against the 50 Hz AC interference.RESULTS:A 100 ù resistor or a 200 kù resistor were connected in series in the input loop so as to produce the imbalance electrode impedance status.When the imbalalice electrode impedance was 100 ù,the amplifier output was 1.69 Mv,and CMRR was 125.8 Db.When the imbalance electrode impedance was 200 k ù,the amplifier output was 1.78 Mv,and CMRR was 125.3 Db.Two voltage sources(20 Hz,amplitude of peak to peak value 50 ì V,opposite phases)were used to produce differential mode signals.The amplification gain was 1000 times.In the input loop of the circtilt mentioned above,a 200 kù resistor was connected in series to create the inabalance electrode impedance status.The amplifter output the peak-to-peak value 50 Mv.The fast Fourier transform(FFT)frequency spectrum of the output wave contained no 50 Hz spectrum line.CONCLUSION:Through the emulation experiment and the real application.we can all find that the amplifier has good signal amplification performance and anti-interference capabillty in intensive 50 Hz AC interference environments and severe imbalance electrode impedance Status.

Objective: To explore children's self-concept differences in age,sex and area during early adolescence.Methods: 533 children aged from 8 to 13 years were surveyed with the Piers-Harris Children's Self-Concept Scale.Results: ①Children's self-concept as well as its six components developed unequally as age grew.Significant differences existed in the Intellectual and School Status Subscale and the Physical Appearance and Attributes Subscale among children of different ages.②Girls did significantly better than boys in Behavior,Intellectual and School Status and Popularity subscales.③Children in urban areas scored significantly higher than those from the countryside in Physical Appearance and Attributes Subscale.Conclusion: There is certain uniqueness in children's general self-concept as well as its different components,according to children's ages,sexes and areas during early adolescence.

Objective To establish a method for the determination of phthalates in water by solid phase extraction-gas chromatography-mass spectrometry(SPE-GC-MS).Methods The water samples were extracted and enriched by solid phasse extraction,using 10%methanol-methyl tert-butyl ether as eluant,dimethylphthalate(DMP),diethylphthalate(DEP),dibutylphthalate (DBP)and diethylhexylphthalate(DEHP)were determined by gas chromatography-mass spectrometry with selected ion monitoring mode(SIM).Results The concentration had a good linear range in the range of 0.00~10.00?g/ml,the correlation coefficient was above 0.998.The detection limit of DMP,DEP,DBP and DEHP were 2.7,2.1,1.6 and 2.5 ng/L respectively,the average recovery rate and the RSD of the method were 78.0%～102.5%and 3.3%～7.8%respectively.Conclusion This method,with small amount of solvent,is simple,fast,accurate and is applicable to the determination of phthalates in water.

SUMMARY Lymphoma is a systemic disease. It is not uncommon to be found involved in digestive or central nervous system. However, lymphoma involved in these two systems at the same time is rare. The clinical feature of a case of lymphoma with gastrointestinal bleeding and limbs weakness was investigated and the literature was reviewed. The patient came to our hospital with melena and hematemesis. She was diagnosed as gastric ulcer by gastroscopy and biopsy showed lymphoma. Two days after she came to hospital, the patient presented with progressing limbs weakness. Magnetic resonance imaging (MRI) showed irregular abnormal signals in T2-T4 vertebra, which was enhanced obviously. A strip abnormal signal could be seen in spinal cord and involved in neighboring centrum and ribbing. The lesion extended to paravertebral tissue. The final diagnosis was lymphoma involved in stomach and spinal cord. Diseases presented with both upper digestive tract bleeding and symptoms of central nervous system were rare, including malignancies, virus infection and some therapy. Lymphoma was one of the causes. On the other hand, spinal cord ischemia might occur after gastrointestinal bleeding. Thus, doctors should examine the patients carefully to diagnose these diseases.

Objective: To observe the role of nutritional support in treatment of chylous leakage after thyroid carcinoma operation.Methods: The parenteral nutrition combined with somatostatin and re-operation was used in treatment of 2 cases of chylous leakage after thyroid carcinoma operation.Fluid volume from neck drainage catheter and plasma albumin concentration were determined in 2 cases.Results: Fluid volume from neck drainage catheter rapidly reduced in 2 cases after using somatostatin and parenteral nutrition.1case was cured after conservative treatment.1 case was cured after re-operation combined with nutrition support.Conclusion: By using nutrition support,fluid volume from neck drainage catheter can be obviously reduced and serum albumin or nutritional state improved in chylous leakage patients after thyroid carcinoma operation.

OBJECTIVE To explore the incidence of the nosocomial infection in patients with mental diseases,(analyze) the correlative factors and then reduce the incidence.(METHODS) By using the retrospective method,the(inpatient) cases in psychiatry department from Jan 2000 to Dec 2004 were surveyed and statistically analyzed.(RESULTS) There were 313 cases of nosocomial infection from 9 089 inpatients with mental diseases.The infection rate was(3.44%.) The total rate had been dropped year by year.The major sites of the infection were the(upper)(respiratory) tract(34.82%),the gastrointestinal tract(20.45%) and the urinary system(18.53%).The(infection) rate in ladies patient area(3.83%) was significantly higher than that of gentlemen patient area(3.07%)(P