Neoadjuvant radiotherapy could decrease the local recurrence rate,increase the probability of the anal sphincter preservation,improve survival rate and the quality of patients' lives.For stage Ⅲpatients with rectal cancer,the recurrence rate is higher in short-course radiotherapy compared with conventionally radiotherapy.Molecular markers combined with gene technology can be used as radiosensitivity indicators.Conventional radiotherapy has a definite effect and radiotherapy combined with chemotherapy has better efficacy.The extensive researches of diverse molecular markers,gene expression profiling and gene chips for rectal cancer provide the basis of personalized treatment.

0.05).HOMA-IR of both two models were higher than that of controls with model ⅰ(8.89?0.86) significantly higher than model ⅱ(6.86?0.48). Conclusion:The model of DHEA+INS is more similar to human PCOS in the morphology of ovary and the degree of insulin resistance.

Biotherapy is an effective treatment strategy for advanced renal cell carcinoma. Cytokine-based biotherapy with interleukin-2 and interferon-? is the first line treatment for renal cell carcinoma, but its response rate is still low and toxicity and side effects are relatively high. Among preclinical biotherapy approaches for renal cell carcinoma, targeted therapy is a promising measure and some new drugs will be used as first line treatment for renal cell carcinoma in near future, allogeneic stem cell transplantation and vaccination are effective for selected subset of patients but are necessary to be evaluated by phase Ⅲ clinical studies, adoptive immunotherapy and gene therapy need to establish the benefit and safe by further studies.

Objective To evaluate the curative effect of valproate and levetiracetam in children with epilepsy.Methods32 patients in the first people's hospital of Xiaoshan district from March 2015 to November 2016 application of levetiracetam in treatment of children with epilepsy as the study group, another year over the same period in 35 cases of infantile epilepsy in children in our hospital using sodium valproate treatment as the observation group, two groups of children with different drugs in the treatment of the obtained to compare therapeutic effect.ResultsCompared with the control group (71.9%), the effective rate of the treatment group was significantly higher than that of the control group (P<0.05), and the effective rate was 85.7%.ConclusionSodium valproate is an ideal drug for the treatment of epilepsy in children, the two drugs have a certain anti epileptic effect, but compared to the effect of sodium valproate in the treatment of clinical advantages.

Objective The paper applies Combination Evaluation Methods to the comprehensive evaluation of 31 cities' New RCMs condition in Fujian Province in 2007.Methods Four single Comprehensive Evaluation methods were employed to evaluate the results which were then combined by Combination Evaluation Methods.Results The results of Combination Evaluation Methods were more stable and accurate than those of single Comprehensive Evaluation methods.Conclusions The results of Combination Evaluation Methods are more stable and reliable.

Objective To discuss postoperative analgesia effect of patient automatic controlled epidural analgesia (PCEA) and cocktail therapy (CT) after total hip replacement. Methods Eighty-eighty patients of selective total hip replacement were selected, and the patients were divided into PCEA group and CT group by random digits table method with 44 cases each. The postoperative resting state and active state visual analogue score (VAS), dosage of opioid, discharge time, postoperative complications, postoperative sleep quality score and hip joint mobility were compared between 2 groups. Results The resting state and active state VAS in PCEA group 12, 24 and 48 h after operation were significantly lower than those in CT group, resting state: (3.68 ± 1.45) scores vs. (4.23 ± 1.14) scores, (2.61 ± 1.04) scores vs. (3.92 ± 1.23) scores and (2.31 ± 0.97) scores vs. (3.56 ± 1.21) scores, active state:(4.54 ± 1.63) scores vs. (5.87 ± 2.11) scores, (3.51 ± 0.94) scores vs. (4.34 ± 1.07) scores and (3.01 ± 0.95) scores vs. (4.05 ± 1.17) scores, and there were statistical differences (P<0.05). But there were no statistical differences in VAS 72 h after operation and at discharge between 2 groups (P>0.05). The dosage of opioid in PCEA group was significantly lower than that in CT group:(9.58 ± 5.35) mg vs. (11.27 ± 4.48) mg, and there was statistical difference (P<0.05). The incidences of nausea vomiting and headache dizziness in CT group were significantly lower than those in PCEA group: 20.45% (9/44) vs. 45.45% (20/44) and 4.55% (2/44) vs. 13.64% (6/44), and there were statistical differences (P<0.05). There were no statistical differences in length of hospital stay, postoperative sleep quality score and postoperative hip joint mobility between 2 groups (P>0.05). Conclusions Choice of analgesic regimen of choice should not be made only according to the length of hospital stay. Individualized treatment is recommended. According to specific circumstances and needs of patients, patients with less anesthetics and a tendency to nausea should use PCEA, and for chronic pain patients CT may be more effective.

For professional degree graduate students, we improved the clinical teaching of pe-diatric surgery, on the basis of traditional forms of practice teaching, combining application of longitu-dinal cross major pediatric surgical practice. We had the student tracking patients from outpatient ser-vice and by going through the process of after examination, treatment, follow-up, and summarizing. students learnt all characteristics of the disease, expended their knowledge and grasped the correct, novel clinical thinking of diagnosis and treatment. The implementation of these measures obtained sat-isfactory teaching effect.

OBJECTIVE: To evaluate short term quality of life of patients with chronic rhinosinusitis by using Chinese version of the sinonasal outcome test-22 (SNOT-22) and to formulate an ideal therapy system for patients with chronic rhinosinusitis. METHOD: Using prospective randomized controlled design,we chose the SNOT-22 to evaluate and compare 78 CRS patients' quality of life (QOL) before surgery, at 1-month,3-month, 6-month and 9-month after functional endoscopic sinus surgery(FESS). At the same time, we randomly chose 100 healthy controls to compare their QOL with those of CRS patients after FESS. RESULT: We found that except for 5 items (cough, ear expanding, otalgia, facail pain and weary ), the grade of 17 other items of CRS patients were significantly higher than those of the healthy controls (P<0. 05). There was no significant difference in 7 items (olfactory sensation, hypogeusis, backflow of nasal discharge, difficult to fall asleep, bad sleep, bad work efficiency, depression, embarrassment ) at 3 months after FESS between chronic rhinosinusitis patients and healthy controls (P>0. 05). There was no significant difference in 9 items (blow noses, sneeze, rhinorrhea, nasal discharge thickness, dizziness, night wake, tired of wake, attention deficit, sense of loss) at 6 months after FESS between chronic rhinosinusitis patients and healthy controls (P>0. 05). There was no significant difference in nasal obstruction at 6 months after FESS between chronic rhinosinusitis patients and healthy controls (P>0.05), at this time the totle grade was normal (P>0. 05). The recovery period of QOL in patients was about 9 months (P>0. 05). The 5 great items were nasal obstruction, olfactory sensation, hypogeusis, nasal discharge, nasal discharge thickness and blow noses. There was no difference in items except for bad sleep replacing nasal discharge thickness between 1-month and 9-month after surgery. CONCLUSION The Chinese vesion of SNOT-22 could evaluate QOL of CRS patients in this area. The recovery of QOL of CRS patients needs about 6 months after FESS, but problems of olfactory sensation, hypogeusis, nasal discharge and difficult to sleeep still needs to be resolved.
Asian Continental Ancestry Group ; Chronic Disease ; Humans ; Nasal Obstruction ; Prospective Studies ; Quality of Life ; Rhinitis ; complications ; surgery ; Sinusitis ; complications ; surgery ; Smell ; Treatment Outcome

OBJECTIVE To analyze the relationship of VEGF-C expression,lymphatic microvessel density and cervical lymph node metastasis in human laryngeal cancer,as well as the relationship of VEGF-C expression and lymphatic microvessel density.METHODS VEGF-C expression and lymphatic microvessel density were detected in 47 laryngeal cancer tissues with SP immunohistochemical method. RESULTS The positive rates of VEGF-C in theⅠ,Ⅱ,Ⅲpathological grade level were 55 %,72.22 %, 88.89% respectively,and its expression was significantly correlated with tumor differentiation(P

Abstract: Objective　To explore the accurate diagnosis of children with suspected rare inherited metabolic diseases, and to compare the application value of mass spectrometry and genetic testing in the diagnosis of rare inherited metabolic diseases (IMD). Methods　The clinical information, mass spectrometry, and genetic results of children with suspected rare inherited metabolic diseases admitted to the Department of Pediatrics, the Affiliated Haikou Hospital of Xiangya Medical College, Central South University from March 2017 to December 2021 were analyzed retrospectively. Results　156 children with suspected rare inherited metabolic diseases were detected by mass spectrometry, 67 cases were positive and 89 cases were negative. Children with positive initial examination were retested, and 19 cases were positive. Among the retest positive cases, 13 cases were given genetic testing, and 9 cases were positive and 4 cases were negative. Among the initial negative cases, 54 children with poor therapeutic effect and high clinical suspicion of inherited metabolic diseases completed genetic testing, 15 cases were positive and 39 cases were negative. The results of the two detection methods were compared, the positive rate of mass spectrometry was 19.4%(13/67), and the positive rate of genetic testing was 35.8%(24/67). The continuity correction of Pearson's chi-square test of continuity correction suggested that the results of genetic testing and mass spectrometry were different, and the difference was statistically significant (P<0.05). Taking genetic testing as the gold standard, the sensitivity and specificity of mass spectrometry detection were 37.5% (95%CI:19.6%-59.2%) and 90.7% (95%CI:76.9%-97.0%), respectively. Among the 24 confirmed cases, 5 cases were diagnosed by gene panel and 19 cases were diagnosed by whole exome sequencing (WES). One case diagnosed by WES had no pathogenic mutation detected by gene panel before diagnosis. The detection of DNM1L gene c.1040C>G and AMN gene c.651+1G>C are novel pathogenic gene variants, which have clinical significance. Conclusions　The ability of mass spectrometry in the diagnosis of inherited metabolic diseases is limited. Genetic testing, especially whole exome sequencing, can be the first choice for individualized diagnosis of suspected rare inherited metabolic diseases. In addition, the new mutation sites found by WES in this study enriched the pathogenic gene mutation spectrum and provided direction for further functional biological experiments.