Objective:To study the characteristic of mandibular kinesiography(MKG) of the patients wearing linear occlusal denture or anatomic occlusal denture, and its relation with masticatory function. Methods:The characteristic tracks, range and speed of mastication movement of two groups of patients, 33 wearing linear occlusal dentures and 30 wearing anatomic occlusal dentures, were recorded by MKG and statistically compared.Results:Differences of mandibular movement track in linear occlusal denture group from that of the anatomic occlusion group were found as following:①There was no occlusal contact slide on the frontal plane track. The track of protrusion movement on sagittal plane was a straight line.②The maximum speed of closing of linear occlusal dentures was apparently slower than that of anatomic occlusal dentures (P

Mantle cell lymphoma (MCL) is a rare subtype of B-cell non-Hodgkin's lymphomas (NHLs). MCL comprises distinct subtypes with different pathological characteristics and clinical features. However, MCL remains incurable by intensified first-line regimens con-taining cytarabine and involving consolidation with high-dose therapy and autologous stem cell transplantation. Recently discovered somatic mutations and aberrant intracellular signaling pathways have been demonstrated to play an essential role in the pathogenesis of MCL. The related novel therapeutics, such as Btk inhibitors, PI3K inhibitors, and immune modulators, have exhibited promising ther-apeutic effects on untreated or even relapsed/refractory MCL. The development of an efficient combination therapy is urgently need-ed to improve the survival of MCL patients in the future.

Animals ; Fatty Liver ; complications ; genetics ; metabolism ; virology ; Hepatitis B virus ; genetics ; isolation & purification ; physiology ; Hepatitis C, Chronic ; complications ; genetics ; metabolism ; virology ; Humans

Female ; Hospital Administration ; Humans ; Male ; Physical Examination ; methods

This paper reviews the recent advances in recombinant expression and purification of defensins, including the choice of host cells, vectors and expression strategies in prokaryotic and eukaryotic cell ex- pression systems, as well as the status of purification processes. By summarizing the problems existed in the production and clinical applications of defensins, the authors here also pointed out the research directions for defensins, and conceived the prospects for its exploitation in the future.

Abnormalities, Multiple ; diagnosis ; Colon ; abnormalities ; Humans ; Infant, Newborn ; Male ; Peristalsis ; Syndrome ; Urinary Bladder ; abnormalities

Animals ; Carboxylic Ester Hydrolases ; metabolism ; Chickens ; Drosophila ; Enzyme Activation ; Humans ; Mice ; Nervous System Diseases ; chemically induced ; enzymology ; physiopathology ; Organophosphate Poisoning ; Phosphorylation

Brain Abscess ; etiology ; Female ; Humans ; Leuconostoc ; pathogenicity ; Male ; Sepsis ; complications ; microbiology

Adult ; Animal Experimentation ; Female ; Hemorrhagic Fever with Renal Syndrome ; etiology ; Humans ; Male ; Medical Laboratory Personnel ; Middle Aged

Objective: The dynamic changes of eight active constituents and dry weight of Acanthopanax senticosus leaves in different periods were investigated, and the suitable harvesting period of A. senticosus leaves was discussed. Methods: The leaves of A. senticosus were collected at different times, and the dry weight of one hundred leaves was determined by electronic balance. The contents of L-phenylalanine, protocatechuic acid, syringin, chlorogenic acid, caffeic acid, rutin, hyperoside, and quercetin in the leaves of A. senticosus in different periods were determined by HPLC, and the total amount of accumulation of the eight active ingredients was calculated and combined with the analysis results of the principal component analysis method for comprehensive evaluation. Results: The results showed that the vegetative dry weight of A. senticosus increased during the period from S1 to S5, and increased most rapidly in S1-S2. The content of eight active constituents in the leaves of A. senticosus showed dynamic changes in different periods. The content of acid reached the maximum in S1 (June 3); The other seven components reached the maximum in S2 (July 3), and the results of principal component analysis also showed A. senticosus leaves collected in S2. The comprehensive scores of the eight active ingredients in leaves were the highest; The total accumulation of the eight active ingredients in different periods increased first and then decreased. During the period from S1 to S2, the total amount showed an upward trend, and reached the maximum at S2. Conclusion: According to the changes of dry weight and eight active ingredients in A. senticosus leaves in different periods, the best harvest time is around S2 stage (from late June to early July) which provides basic information for determining the suitable harvest time of A. senticosus leaves.