Rituximab in the combination of CHOP regimen has been widely used as the standard treatment of several kinds of B cell non-Hodgkin lymphoma (B-NHL),but there are still about 1/3 of the late B-NHL patients become primary and secondary resistant to the drug.Recently,many translational research progress in malignant lymphoma promoted the development of promising candidate drugs for the treatment of lymphoma.The advances in translational research field were summarized in this manuscript.

Advances in clinical transformation research has facilitated discovery of a number of novel somatic mutations and aberrant intracellular signaling pathways involved in malignant proliferative B-cell lymphoma.Meanwhile,small molecular inhibitors targeting those mutation genes or signaling pathways have also been shown to be effective in treating relapsed and refractory B-cell non-Hodgkin lymphoma.This paper reviewed important discoveries in clinical transformation research in lymphoma field in 2013.

Adenoma, Pleomorphic ; Adult ; Female ; Humans ; Nose Neoplasms

Aged ; Amiodarone ; adverse effects ; Chemical and Drug Induced Liver Injury ; etiology ; Drug-Related Side Effects and Adverse Reactions ; Humans ; Male

Objective To investigate the effects of children's mentality on mental symptoms during recovery period of ketamine anesthesia. Methods According to the mentality, forty-five children undergoing smalminor surgery were assigned into active group, stable group and fretful group with 15 cases each. Child was anaesthetized by ketamine alone. RP, BP, HR and SpO_2 were recorded at the end of operation, 5,10 and 30 min after operation. Meanwhile the expression, feeling, behavior, talking and activity were observed. Results RR, BP, HR in active group and fretful group were significantly higher than those in stable group. There was a significant difference in the expression, feeling, behavior, talking and activity among three groups. Conclusion Children's mentality has a significant effect on mental symptoms and hemodynamics during recovery period of ketamine anesthesia.

Cell culture of Ginseng (Panax ginseng ) was conducted under different K_(La)?,with other conditions kept coustant. Results showed that the best range of K_(La)? for Gingseng cell cultu re was 18~27h-1.

[Objective]To evaluate curative effect of armor plate and xenogenic bony plate in congenital pseudarthrosis of the tibia.[Method]Five cases of congenital pseudarthrosis of the tibia were reviewed from 1998 to 2004,there were 2 men and 3 women,average age was 5.8(ranged,3~10)years.All the patients were treated by armor plate and xenogenic bony plate.[Result]All of the patients were followed up for more than 3 years(from 3 years to 7 years),four cases achieved bony union.Average time of bony union was 5 months.The lower limbs resumed walking ability and bear a heavy burden.[Conclusion]Outcome of 4 patients demonstrates that treatment of congenital pseudarthrosis of the tibia with armor plate and xenogenic bony plate is a reliable treatment.

Objective To study the value of MRI in the diagnosis of spinal metastasis.Methods MR imaging manifestations of spinal metastasis in 85 cases were retrospectively analyzed.46 cases underwent CT and/or X-ray in the 85 cases.Results Totally 388 metastatic vertebra in the 85 cases were detected by MRI.388 vertebras showed hypointensity on T1WI.354 vertebra showed mixed signal intensity and 34 vertebra showed hypointensity on T2WI.All of the vertebra showed hyperintensity on T2WI/STIR.54 vertebra showed pathologic fracture,53 vertebra were protrusion in postetrior,54 vertebra with appendages damage and paravertebral soft tissue mass presented and vertebral canal involved in 30 cases.18 cases were detected with lesion in 46 cases having X-ray and/or CT data,the positive rate was 39.11%(18/46).Conclusion MRI can detect spinal metastatic lesion early,the extent and degree of the tumors can be judged by MRI exactly.

Objective To study MR manifestations of biliary obstructive disease.Methods MR examination (Philips Gyroscan INTERA 1.0T)in 69 patients with biliary obstructive disease were performed.The conventional sequences included:T1WI/FFE,T2WI/TSE,T2WI/SPIR and contrast-enhanced at axial position,coronal B-FFE and MRCP.All images in all cases were compared with the results of operation and pathology.Results 43 cases were benign disorder,of them,42 cases were choledocholithiasis,one case was choledochal cyst.Choledocholithiasis presented as single or multiple round or ovoid with low signal.The direct sign of malignant lesions (26 cases) was the masses with slightly high signal at the obstructive part,the indirect sign of malignant lesions was obstruction or narrow of bile duct. The MR diagnostic accuracy of obstructive location was 100%, and the accuracy for evaluating the causes of obstruction was 89.9%.Conclusion MRCP combining with B-FFE and routine MRI, analysising the direct sign and indirect sign, can improve the diagnostic accuracy of obstructive jaundice.

The full length cDNA of ?1,3 galactosyltransferase gene was amplified by RT PCR from the peritoneal macrophages of BALB/c mice, which was subcloned into an eukaryotic expression vector pCDNA3 1/V5 HisA, and it was confirmed by DNA sequencing. The gastric cancer cell GC9811 was transfected with pCDNA3 1/V5 HisA?1,3GT by Lipofectamine TM 2000. The positive clone was screened by G418 for two months and confirmed by RT PCR. The gastric cells expressing Gal?(1,3)Gal epitope were detected by immuohistochemisty, and they were killed by naive antidoby specific to Gal?(1,3)Gal epitope. The results showed that the pCDNA3.1/V5 HisA?1,3GT was successfully constructed, and the transfected gastric cancer cells could highly express Gal?(1,3)Gal, which promoted lysis of the cancer cells by normal human serum.