Objective:To explore the effect of xanthine oxidase inhibitor allopurinol on left ventricular remodeling and function in rats with myocardial infarction(MI).Methods:MI models were produced by ligation of anterior descending coronary artery.The survivals were randomly divided into 3 groups:sham operation group,MI group and allopurinol group[50mg/(kg?d),n=15]. After 28 days,the parameters of echocardiogram and hemodynamics were investigated.The infarct size,LV weight index were detected,too.In addition,the activities of xanthine oxidase(XO) and ?O2-,?OH-scavenging were examined;the expression of XO was detected by Western blot.Results:Compared with sham group,the LV weight index and expression of XO were increased;the activity of XO was boosted but the heart function and activities of ?O2-,?OH-scavenging were decreased(P

Hematopoietic Stem Cell Transplantation ; Humans ; Leukemia ; therapy

China ; Humans ; Multiple Myeloma ; therapy

Graft vs Host Disease ; diagnosis ; therapy ; Hematopoietic Stem Cell Transplantation ; adverse effects ; Humans ; Postoperative Complications ; diagnosis ; therapy ; Transplantation Conditioning

By research on the universal standards classification of medical device, according to their functions and scope of application, they are divided into two levels, universal standard architecture is proposed, to provide opinions and suggestions for standard system construction of medical devices.
Equipment and Supplies ; standards ; Humans

Hematopoietic Stem Cell Transplantation ; Humans

China ; Hematopoietic Stem Cell Transplantation ; adverse effects ; methods ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive ; therapy

Science of Meridians and Acupoints of the new version has been obviously improved in terms of bookbinding and printing quality and the concrete textbook content as compared with the textbook of the old version. However, some questions had been discovered during actual usage in the past semester. The writer makes the discussion from 4 aspects, named content arrangement, content statement, content correction and phonetic notation of rare words. The writer puts forward his own opinions on a part of acupoints essentially and points out some mistakes in the textbook.
Acupuncture Points ; Acupuncture Therapy ; Books ; Humans ; Meridians

China ; Hematopoietic Stem Cell Transplantation ; Humans

Objective To investigate the role of PAK1 in the development of pancreatic cancer.Methods 33 cases of pancreatic cancer in Renmin Hospital of XianTao were selected in this study. 33cases of pericancerous normal tissues were collected as control group.Immunohistochemical staining were performed to detect the expression of PAK1 in 33 cases of pancreatic cancer and pericancerous normal specimens.Results By Immunohistochemical staining PAK1 were mainly expressed in the cytoplasm. The positive rate of PAK1 expression in pancreatic cancer were 69.7 ％(23 / 33),which was significantly higher than that of control group[27.3 ％(9 / 33),x2=11.89,P =0.001].In addition,overexpression of PAK1 was more frequently in Ⅲ+Ⅳ stage pancreatic cancer tissue[93.3 ％(14/15)],compared with Ⅰ + Ⅱ stage [50.0 ％( 9 / 18 ),x2=5.367,P=0.021]. Conclusion The PAK1 protein may be associated with the occurrence and development of pancreatic cancer.