1.Impact of the CD4~+CD25~(nt/hi)CD127~(lo) regulatory T cells on the immune status and disease progression in HIV-1 infected individuals
Mingkui ZHOU ; Yile XUE ; Juli GONG ; Leiming ZHOU ; Xiaohong ZHENG ; Jing GAI ; Fangwei SHEN ; Wei ZHANG ; Zhen NING ; Qing YUE ; Wei LU ; Qichao PAN ; Laiyi KANG ; Ping ZHONG ; Wensi ZHU ; Ying WANG
Chinese Journal of Immunology 1999;0(12):-
Objective:To investigate the impact of the CD4+CD25nt/hiCD127lo regulatory T cell subset frequency on the immune status and disease progression of Chinese HIV-1 infected individuals.Methods:83 untreated HIV-infected individuals and 312 healthy control individuals of four distinct age groups were enrolled in the research. The CD4+ T cell absolute counts, phenotypes and frequency determination of CD4+CD25nt/hiCD127lo Regulatory T cell subsets was performed on freshly obtained whole blood samples by 3-color immune staining flow cytometry. The HIV-1 specific cellular immune function was test at single cell level by ELISpot. The corresponding plasma viral load was determined by NASBA.Results:The frequency of peripheral CD4+CD25nt/hiCD127lo regulatory T cells of HIV infected individuals in distinct disease progression status was dissimilar in China , and significantly increased in contrast to the healthy controls(P
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