Objective To explore the relationship between the plasma homocysteine(Hcy)level and carotid atherosclerosis in the patients with H hypertension .Methods 200 patients with essential hypertension were divided into the research group (complicating homocysteinemia) and the control group according to whether complicating homocysteinemia .Carotid artery was detected and its average intima‐media thickness (IMT) was measured for all the patients by GE LOGIQ3 type color Doppler ultrasonograph .Simul‐taneously ,the levels of plasma Hcy ,triglycerides ,total cholesterol ,high‐density lipoprotein cholesterol and low density lipoprotein cholesterol were detected .Results Average carotid IMT in the research group was significantly higher than that in the control group(P<0 .05) ,and with the increase of the Hcy level ,IM T was gradually thickened ;in addition ,the atherosclerosis degree of ca‐rotid artery was significantly associated with the Hcy level (P<0 .05) .Conclusion The Hcy level is closely related with the ather‐osclerosis degree of carotid artery in the patients with H hypertension .

Objective To study the value of the multiple tumor markers protein chip system (C‐12) in the clinical application . Methods The levels of 12 kinds of tumor markers were detected in 5 000 healthy people (healthy physical examination group) ,4 500 patients with benign tumor and inflammation (benign disease group) and 5 500 patients with malignant tumors (malignant tumor group) .At the same time 1 369 negative specimens in the malignant tumor group were performed the comparative analysis with the electrochemiluminescence method by adopting the fully automatic chemiluminescence immune analyzer .Results The posi‐tive rate in the malignant tumor group by using C‐12 was 75 .11% ,which was significantly higher than 20 .31% in the benign dis‐ease group and 4 .34% in the healthy physical examination group ,the difference between the two groups in pair had statistical sig‐nificance(P< 0 .05) .The sensitivity of C‐12 for detecting malignant tumor was 75 .11% ,the specificity was 95 .66% ,and the posi‐tive rate of joint detection was significantly higher than that of single marker ,the difference between them was statistically signifi‐cant (P< 0 .05) .Conclusion The 12 tumor markers protein chip joint detection method has certain reference value for the diagnosis in the patients with tumor .Detecting multiple tumor markers can obviously increase the diagnosis sensitivity of malignant tumors , can be used in the prognosis and the curative effect observation ,at the same time can also be used as one of screening measures for early tumor among asymptomatic population .