The paper expounds the function and significance of establishing CBM retrieval strategies for commonly used words, it could not only promote the quality and efficiency but also have important significance to upgrade and standardize the quality of novelty as-sessment report.

OBJECTIVE: To investigate the effect of bromocriptine on the expression of Pit-1 in prolactinoma rats. METHODS: Firstly, to prepare prolactinoma model in rats. Adult Wistar rats were divided into two groups at random. The rats in control group were subscutaneously implanted with a blank implant. Rats in 17β-estradiol group were implanted with 17β-estradiol-containing implants. Secondly, rates in 17β-estradiol group were divided into two groups at random: model group and bromocriptine group. Water was administrated to rats in model group. Bromocriptine (0.225 mg · kg-1 · d-1) were orally administrated to rats in bromocriptine group, the rats in control group were orally administrated with water. After four weeks of treatment, all the animals were executed. Each pituitary gland was weighed. Serum prolactin (PRL) levels were measured by RIA method. Pit-1 mRNA levels in pituitaiy tissue were measured by RT-PCR method. RESULTS: The weights of pituitary gland and PRL levels in 17β-estradiol group were individually higher than those in control group (P<0.001). The expression levels of Pit-1 mRNA in bromocriptine group was obviously lower than that in model group (P≤0.001). CONCLUSION: Bromocriptine has potential preventive effect to estrogen-induced rat prolactinoma. The decrease of Pit-1 mRNA level may be involved in the mechanism of anti-prolactinoma effect of bromocriptine.

Objective To investigate the auditory condition in adults with hearing-impairment and evaluate the outcome of the hearing aid. Methods The threshold of air-bone-conduction audiometry and binaural hearing aid in 91 adults were determined with pure tone audiometry,and their satisfaction to hearing aids were investigated with free interview. Results The threshold of hearing and hearing aid were positively correlated. The satisfaction did not significantly correlate with the threshold of hearing aid, but with the time of deprivation of hearing. The hearing threshold classification was better in the patients with the audiogram of flat, raising, slow down type than with audiogram of Shu type, which defined as hearing reacted only in 1 or 2 frequency. Conclusion It is important to improve the primary otology protection, as well as the rehabilitation from the hearing aids.

Medicine, Chinese Traditional ; Mind-Body Relations, Metaphysical

Objective:To explore the efficacy of abdominal acupuncture in treating patients with osteoporotic vertebral compression fracture (OVCF).
Methods:Forty-five eligible OVCF patients were randomized into an abdominal acupuncture (AA) group, a body acupuncture (BA) group and a medication group according to the random numbers generated by the SPSS 11.5 version software, 15 subjects in each group. Patients in the medication group were intervened by Ossotide injection (intravenous injection), Caltrate (oral administration), Alfacalcidol (oral administration), and Salcatonin injection (muscular injection). In addition to the intervention given to the medication group, patients in the AA group additionally received acupuncture at Zhongwan (CV 12), Xiawan (CV 10), Qihai (CV 6), Guanyuan (CV 4), Shuifen (CV 9), and Huaroumen (ST 24); while patients in the BA group additionally received acupuncture at Jiaji (EX-B 2, superior and inferior to the affected area) points, Ashi points, Weizhong (BL 40) and Chengshan (BL 57). For the AA and BA groups, the acupuncture treatment was given once a day, 6 d per week, for 3 weeks in total. Prior to the intervention, and respectively after 1-week treatment, 2-week treatment and 3-week treatment, visual analogue scale (VAS) and Barthel index (BI) were adopted to evaluate pain degree and activities of daily living (ADL).
Results:After intervention, the VAS and BI scores were significantly changed in the three groups (P<0.05). Respectively after 1-week, 2-week and 3-week treatment, the VAS and BI scores in the two acupuncture groups were significantly different from those in the medication group at the same time point (P<0.01). After 1-week and 2-week treatment, the improvements of VAS and BI scores in the AA group were more significant than those in the BA group(P<0.05); after 3-week treatment, there was no significant difference in comparing the VAS score between the two acupuncture groups (P>0.05), but a significant difference was found in comparing the BI score (P<0.05).
Conclusion:Abdominal acupuncture can produce a more significant effect in improving VAS and BI scores in OVCF patients than body acupuncture and pure medication treatment, and it’s efficient and causes few sufferings.

Objective To evaluate the efficacy in aromatase inhibitors and tamoxifen on Luminal postmenopausal breast neoplasms.Methods PubMED,Science Direct,EBSCO Host,EMbase,The Cochrane Library,CNKI,CECDB and CQVIP were retrieved,the evaluation methodology included.The quality of the included studies and extracted data should be researched rigorously.Review Manager 5.0 software was used to evaluate the quality standards of randomized clinical trial (RCT).Results Twelve RCT were selected,included 2634 patients,1354 cases of treatment group (use aromatase inhibitors),1280cases of control group (use tamoxifen).The results of the evaluation of the system:compared to control group,treatment group significantly improved disease-free survival in 1 year (RR =1.10,95％ CI 1.01-1.19),disease-free survival in 3 years (RR =1.09,95％ CI 1.05-1.13),the overall efficiency in 1 year (RR =1.21,95％ CI 1.12-1.30),furthermore treatment group significantly reduced the incidence of cardiovascular diseases in 3 years (RR =0.47,95％ CI 0.27-0.83),but there was no significant difference in the incidence of bone and joint disease in 3 years between the 2 groups (RR =0.99,95％ CI 0.61-1.61).Conclusion Compared to tamoxifen,the efficacy of aromatase inhibitors is excellent in treatment of Luminal postmenopausal breast neoplasms,it is worth promoting.

Objective:To analyze the operational efficiency of public specialized hospitals and private specialized hospitals in Guangdong.Methods:Using the Malmquist index model of DEA to analyze operational efficiency of public specialized hospitals and private specialized hospitals in Guangdong from 2010 to 2015.Results:From 2010 to 2015,the overall operation efficiency of specialized hospitals were in low condition;the operational efficiency of public specialized hospitals was better than private specialized hospitals.Conclusion:Medical and health reform policy should attach great importance to the construction of specialized subject hospitals.Private specialized hospital was the cornucopia of hospital development which needed accurate and professional.

Aim To investigate the protective effects and mechanism of aspirin against focal cerebral ischemia-reperfusion in rats. Methods Right middle cerebral artery was occluded by inserting a thread through internal carotid artery for 2 h, and then reperfused for 72 h. 60 mg?kg -1 dose of aspirin was intragastric administrated at 0 h and 6 h after reperfusion. The brain injured area, the mortality, and cerebral edema were estimated. The apoptotic cells of brain tissue were detected by terminal deoxynucleotidyl transferase mediated dUTP-biotin nick-end labeling (TUNEL) method. Bcl-2 and Bax were detected by immunohistochemical staining method. The activity of calcineurin (CaN) in brain tissue was determined by the inorganic phosphorus method. The content of adenosine 5′-triphosphate (ATP) in brain tissue was separated by capillary electrophoresis. Results By using of aspirin 60 mg?kg -1, all indications were dramatically improved. The injured area of brain [from (10.51?1.12)% to (0.94?0.08)%], the cerebral edema of occluded side [from (82.43?2.0)% to (76.29?0.77)%], and the mortality [from 28% to 0%] were dramatically reduced. In brain tissue of occluded side, 60 mg?kg -1 aspirin helped to reduce the number of apoptotic cells from (26.43?2.0) to (17.53?0.44), increase the ratio of Bcl-2/Bax from (0.61?0.05) to (1.01?0.15), inhibit the activity of CaN from (6.03?1.5) to (3.47?0.96), and improve the ATP level from (10.26?1.02) to (25.65?3.45). Conclusion The neuroprotective effects of aspirin on focal cerebral ischemia-reperfusion injury in rats for 72 h might be attributed to its effects by anti-apoptosis, increasing the ratio of Bcl-2/Bax, inhibiting the activity of CaN, and improving the energy metabolism.

Objective To investigate the effect of Salvia miltiorrhiza extracts on morphine physical dependence in mice. Methods The physical dependence model was induced by repeated sc morphine daily in mice and then withdrawal symptom was induced by ip naloxone. Different doses of S. miltiorrhiza extracts were administrated by ip during or after the induction phase of morphine dependence, and effects of S. miltiorrhiza extracts both by preventive and acute administration on naloxone-precipiated withdrawal symptom in mice were investigated. The potential physical dependence of S. miltiorrhiza extracts was studied. Results Compared to morphine model group, preventive administration of S. miltiorrhiza extracts (100—200 mg/kg) could reduce the number of naloxone-induced withdrawal jumps (P

Objective To investigate the early predictive indexes of curative effect of acute respiratory failure(AFR) treated with noninvasive bilevel positive airway pressure(BiPAP) ventilation.Methods Sixty-eight patients with AFR were treated with BiPAP ventilation.According to the therapeutic outcome,patients were divided into success group and failure group,and the distributions of ages,acute physiology and chronic health evaluation(APACHEⅡ) score,consciousness level as well as arterial blood gas(ABG) measurement before and after the treatment with BiPAP ventilation were compared between the two groups.Results There was statistical difference in the ABG levels of pH and PaCO_2 after 1 hour's treatment with BiPAP ventilation(P0.05).Conclusion The levels of pH and PaCO_2 after 1 hour's treatment with BiPAP ventilation are valuable markers for curative effects in early stadge.If the levels of pH and PaCO_2 fail to improve,the treatment with intubation may be necessary.