Gap junctions are membrane structures made of intercellular channels that allow directly exchange of material and information between adjacent cells. It is the structural basis of gap junctional intercellular communication. Gap junction is aberrant frequently in variety of cancers, which relatives with tumor genesis and metastasis. New anti-cancer drugs targeting gap junctions will be a new direction for tumor treatment.

In the past decades,more and more mutant genes that cause inherited retinal diseases have been found.Meanwhile,many naturally occurring animal models have also been found to show similar gene mutations and phenotypes as the human inherited retinal diseases,which have led to the development of a variety of therapeutic strategies for those traditionally incurable inherited diseases.These models include rod degeneration (rd) mice,such as rd1 model,rd10 model and nmf137.To compare the efficacy of these strategies,this article briefly reviews the recent progress in the treatment of the mouse models with mutations in the subunit of rod phosphodiesterase (Pde6b)gene by pharmaceutical,stem cell and gene therapy in order to find a more effective treatment for retinal degeneration.

On the basis of status and technical characteristics of rehabilitation training instrument in China, this article summarized theconcept and significance of reliability-based design, introduced the technical target of rehabilitation training instruments and the procedureof building a reliability model. The future prospect of applying reliability-based design to rehabilitation training instruments is also discussed.

Humans ; Multiple Myeloma ; complications ; Neuritis ; etiology ; prevention & control ; therapy ; Renal Insufficiency ; etiology ; prevention & control ; therapy

Objective To compare the clinic effects of gatifloxacin and fleroxacin on respiractory infections.Methods 160 patients of low-moderate respiractory infections were divided into observation group (80 cases) and control group (80 cases).Under common therapy,the observation group accepted gatifloxacin injection while the control group accepted fleroxacin injection.The effective rate,bacterial clearance rate and untoward effect were compared between the two groups.Results The effective rate of observation group was obviously higher than control group (88.8％ vs 72.5％,x2 =3.16,P ＜ 0.05).The bacterial clearance rate of observation group was obviously higher than control group (90.0％ vs 78.8％,x2 =6.28,P ＜ 0.05).There were 5 cases of nausea and vomiting in observation group while 3 cases of nausea and 2 cases of nausea and vomiting in control group.The diverse of untoward effect of two groups had no significance (x2 =0.03,P ＞ 0.05).Conclusion Gatifloxacin has a better clinic effect than fleroxacin.Gatifkoracin doesn't increase the untoward effect on respiractory infections.

Objective To explore the clinical curative effect of central venous catheter drainage in treating pleural effusion.Methods 100 cases with pleural effusion were treated by the central venous catheter drainage.The curative effect,complications and adverse reactions were observed.Results Ater treatment for 12 ～ 28d,catheter drainage of 100 patients were all successful at the first time.The clinical effect:completely relieve 40 cases(40.0％),clinical partial remission 47 cases(47.0％),inefficient 13 cases (13.0％),and the total effective rate was 87.0％.There were some complications:pneumothorax 1 case,hemorrhage 2 cases,infection 1 case,pleural reaction 3 cases,pain 3 cases,subcutaneous emphysema 2 cases and take off the tube 1 case,the incidence rate of complications was 13.0％.Conclusion Central venous catheter drainage in t.reating pleural effusion has significant curative effect,which is worthy of clinical application.

Chromosome abnormality has recently been recognized as an important cause of congenital heart diseases(CHD).The tiny fragment deformity of the chromosome may lead to many abnormal genes expression.Recent studies have disclosed that CHD is a part of syndrome attributed to chromosome abnormality.This article reviews chromosome abnormality caused by trisomy chromosome,chromosome deletions,Tuner syndrome and Kleinfelte's syndrome as well as incidence,type,mechanism and prognosis of its complicated CHD.

Objective To study the expression ofinterleukin 10(IL-10) and interleukin 17(IL-17)in patients with acute gastritis,and analyze the clinical significance.Methods The expression of IL-10 and IL-17 in the serum of 58 patients with acute gastritis (gastritis group) and 40 healthy cases (control group) was detected by ELISA.The patients in gastritis group included 23 patients of slight degree,18 patients of middle degree and 17 patients of severe degree.Results The level of IL-10 in gastritis group [(108.321 ±12.302) ng/L] was significantly higher than that in control group [(17.883 ± 13.802) ng/L] (t =18.143,P ＜ 0.01).The level of IL-17 in gastritis group [(127.418 ± 11.410) ng/L] was significantly higher than that in control group [(30.335 ± 14.549) ng/L] (t =22.493,P ＜ 0.01).The level of IL-10 and IL-17 in slight degree,middle degree and severe degree patients was significantly increased [IL-10:(33.486 ± 14.568)ng/L,(106.189 ± 13.583) and (123.875 ± 14.892) ng/L;IL-17:(68.209 ± 9.332),(129.856 ± 11.456),(208.165 ± 12.854) ng/L](P＜ 0.05).The level of IL-10 had positive correlation with IL-17 (r =0.79,P＜0.01).Conclusions IL-10 and IL-17 participate in the pathogenesis of acute gastritis and they have high correlation.IL-10 may restrain IL-17 cells and control the progress of inflammation.

Objective To analyze and investigate the thyroid hormone levels in the patients with coronary heart disease(CHD) . Methods The levels of thyroid hormones were detected by the immunochemiluminescence method in 108 cases of CHD in the car‐diology department of our hospital and 50 healthy controls from July 2012 to October 2014 .The detection results of various indica‐tors were analyzed by using the SPSS19 .0 software and two independent samples t -test .Results In 108 cases of CHD ,11 cases were thyroid dysfunction ,including 3 cases of hyperthyroidism ,5 cases of hypothyroidism ,1 case of subclinical hyperthyroidism and 2 cases of subclinical hypothyroidism .The FT3 level in two CHD groups was significantly lower than that in the control group ,the difference was statistically significant (P< 0 .05) ,although the FT4 level was decreased somewhat ,but the difference compared with the control group was not statistically significant (P>0 .05);the FT3 level in the CHD heart failure group was lower than that in the CHD non-heart failure group ,the difference was statistically significant (P<0 .05) ,the difference in the FT4 level had no statistically significant difference (P> 0 .05);the TSH level in the CHD group was similar to the that in the control group ,the difference was not statistically significance (P>0 .05) .No difference in thyroid hormone levels was observed between male and fe‐male CHD patients (P>0 .05) .Conclusion Monitoring in the change of thyroid hormone levels in the patients with CHD can effec‐tively reflect the severity of illness and conduces to observe the clinical efficacy .

The oculocardiac reflex (OCR) occurs in up to 90% of ophthalmological surgeries,while most of the clinicians consider the performance of OCR is just bradycardia and arrhythmia and therefore ignore other system manifestation such as oculorespiratory reflex( ORR) and oculo-emetic reflex(OER),and so on.OCR appears not only in ophthalmological surgeries,and it also occurs during the endoscopic sinus surgery.A unstable bradycardia associated with stimulation of the mandibular division of cranial nerve V during trigeminal neuralgia pain treatment is also reported.This phenomenon is mostly introduced only as clinical manifestations.Therefore,it is helpful for us to understand the essential characteristic of OCR.The embryonic,anatomy,physiology and electrophysiology were reviewed in this article and thought to term it as oculovagal reflex is more comprehensive.