Gap junctions are membrane structures made of intercellular channels that allow directly exchange of material and information between adjacent cells. It is the structural basis of gap junctional intercellular communication. Gap junction is aberrant frequently in variety of cancers, which relatives with tumor genesis and metastasis. New anti-cancer drugs targeting gap junctions will be a new direction for tumor treatment.

In the past decades,more and more mutant genes that cause inherited retinal diseases have been found.Meanwhile,many naturally occurring animal models have also been found to show similar gene mutations and phenotypes as the human inherited retinal diseases,which have led to the development of a variety of therapeutic strategies for those traditionally incurable inherited diseases.These models include rod degeneration (rd) mice,such as rd1 model,rd10 model and nmf137.To compare the efficacy of these strategies,this article briefly reviews the recent progress in the treatment of the mouse models with mutations in the subunit of rod phosphodiesterase (Pde6b)gene by pharmaceutical,stem cell and gene therapy in order to find a more effective treatment for retinal degeneration.

On the basis of status and technical characteristics of rehabilitation training instrument in China, this article summarized theconcept and significance of reliability-based design, introduced the technical target of rehabilitation training instruments and the procedureof building a reliability model. The future prospect of applying reliability-based design to rehabilitation training instruments is also discussed.

Humans ; Multiple Myeloma ; complications ; Neuritis ; etiology ; prevention & control ; therapy ; Renal Insufficiency ; etiology ; prevention & control ; therapy

Objective To study the main factors of young people the wedge-shaped teeth defect.Methods Random sampling way,746 middle-aged and young people in 20-50 years old with the wedge-shaped teeth defect patients status were checked,the oral examination and questionnaire survey was used to surveyed the factors on the young people of wedge-shaped defects.Results The young people of wedge-shaped defects in the reason,the most common was the mechanical friction 576 cases accounted for 75.4％,followed by etching 422 cases accounted for 56.6％,in addition to bite force fatigue in 112 cases accounted for 15.0％,other 46 cases,accounting for 6.7％.Conclusion The young people oral care has many defects,but also exposed many problems,the wedge-shaped teeth defectand oral care,using habit has the very big relations,and the prevention was the mainly measure for the wedgeshaped teeth defect.

Chromosome abnormality has recently been recognized as an important cause of congenital heart diseases(CHD).The tiny fragment deformity of the chromosome may lead to many abnormal genes expression.Recent studies have disclosed that CHD is a part of syndrome attributed to chromosome abnormality.This article reviews chromosome abnormality caused by trisomy chromosome,chromosome deletions,Tuner syndrome and Kleinfelte's syndrome as well as incidence,type,mechanism and prognosis of its complicated CHD.

Objective To study the expression ofinterleukin 10(IL-10) and interleukin 17(IL-17)in patients with acute gastritis,and analyze the clinical significance.Methods The expression of IL-10 and IL-17 in the serum of 58 patients with acute gastritis (gastritis group) and 40 healthy cases (control group) was detected by ELISA.The patients in gastritis group included 23 patients of slight degree,18 patients of middle degree and 17 patients of severe degree.Results The level of IL-10 in gastritis group [(108.321 ±12.302) ng/L] was significantly higher than that in control group [(17.883 ± 13.802) ng/L] (t =18.143,P ＜ 0.01).The level of IL-17 in gastritis group [(127.418 ± 11.410) ng/L] was significantly higher than that in control group [(30.335 ± 14.549) ng/L] (t =22.493,P ＜ 0.01).The level of IL-10 and IL-17 in slight degree,middle degree and severe degree patients was significantly increased [IL-10:(33.486 ± 14.568)ng/L,(106.189 ± 13.583) and (123.875 ± 14.892) ng/L;IL-17:(68.209 ± 9.332),(129.856 ± 11.456),(208.165 ± 12.854) ng/L](P＜ 0.05).The level of IL-10 had positive correlation with IL-17 (r =0.79,P＜0.01).Conclusions IL-10 and IL-17 participate in the pathogenesis of acute gastritis and they have high correlation.IL-10 may restrain IL-17 cells and control the progress of inflammation.

Objective To explore the clinical curative effect of central venous catheter drainage in treating pleural effusion.Methods 100 cases with pleural effusion were treated by the central venous catheter drainage.The curative effect,complications and adverse reactions were observed.Results Ater treatment for 12 ～ 28d,catheter drainage of 100 patients were all successful at the first time.The clinical effect:completely relieve 40 cases(40.0％),clinical partial remission 47 cases(47.0％),inefficient 13 cases (13.0％),and the total effective rate was 87.0％.There were some complications:pneumothorax 1 case,hemorrhage 2 cases,infection 1 case,pleural reaction 3 cases,pain 3 cases,subcutaneous emphysema 2 cases and take off the tube 1 case,the incidence rate of complications was 13.0％.Conclusion Central venous catheter drainage in t.reating pleural effusion has significant curative effect,which is worthy of clinical application.

Cerebral palsy,a group of motor disorders,does serious harm to children's physical and mental health,and the majority of patients need rehabilitation through life-time.However,the traditional methods of rehabilitation medicine are mainly dependent on the rehabilitation manipulation,which brings heavy and long term burden to family and society.With the rapid development of biomechanics and rehabilitation engineering technology,a new type of the rehabilitation robot,through the integration of rehabilitation medicine,biomechanics,mechanics,electronics,computer science and robotics,and many other disciplines,combines the active and passive exercise and fits the normal movement patterns to achieve the purpose of rehabilitation.The paper,by focusing on taking the rehabilitation robot as an example,summarizes the progresses of the application of rehabilitation robot in children with cerebral palsy,to provide new ideas for the development of children's rehabilitation technology.

Objective To investigate the value of Multi-slice Spiral CT Angiography (MSCTA)in diagnosis of superior mesenteric artery (SMA)diseases.Methods The image features of SMA diseases in 40 patients were reviewed retrospectively using volume rendering (VR),multiplanar reconstruction (MPR),curved planar reconstruction (CPR),maximum intensity projection and other post-processing reconstruction technique.Results 16 patients have SMA ischemia including 8 cases of SMA acute occlusion;1 case of acute occlusion with small intestinal ischemic necrosis who has had surgery to remove the necrotic intestine.8 cases of SMA chronic occlusion;10 cases of spontaneous isolated dissection of SMA;7 cases of true aneurysm of SMA;1 case of SMA pseudoaneurysm associating with infective endocarditic;3 cases of SMA ulcer,including 1 case of inferior mesenteric artery (IMA)severe stenosis;2 cases of severe stenosis of celiac trunk;1 case of occlusion of IMA. In total of 40 cases,13 were with collateral circulation associating with SMA diseases,of which 4 were SMA chronic occlusion,3 were SMA acute occlusion,1 was spontaneous isolated dissection of SMA,1 was SMA pseudoaneurysm,1 was IMA stenosis,1 was IMA occlusion and 2 were celiac trunk severe stenosis,which was included collateral circulation of the anterior and posterior arterial arcades in 3 cases,collateral circulation of the dorsal pancreatic artery in 2 cases,Riolan’s arcade in 10 cases.Conclusion MSCT could clearly display SMA diseases and the establishment of collateral circulation,and evaluate intestinal ischemia.