1.Neurologic outcome of Filipino children diagnosed with central nervous system infection
Aida M. Salonga ; Peter Francis Raguindin ; Mishelle H. Imperial ; Marilyn H. Ortiz ; Martha L. Bolañ ; os ; Maria Lourdes M. Trajano ; Madeleine Grace M. Sosa ; Bernadette Chua-Macrohon ; Jo Janette R. de la Calzada ; Maria Lourdes E. Amarillo
Neurology Asia 2019;24(3):235-242
Neurologic infections are related to chronic and life-long neurologic impairment. We aim
to describe the outcomes of Filipino children with neurologic infections upon, and within one year
from discharge. This data will be useful in developing programs for the prevention and improvement
of outcomes in children with neurologic infections. Methods: This is a multicenter, cross-sectional,
retrospective cohort study at six tertiary hospitals across the Philippines within four years (2007-2010).
A standardized report form was used to collect clinical profile and outcome using inpatient and
outpatient records. Neurologic outcome was classified and staged at 3-, 6-, 9- and 12-months postdischarge. Results: A total of 480 patients were included in the analysis (mean age 4.7 ± 5.3 y), most were bacterial in etiology (275 cases, or 57.3%). Severity of illness on admission (Stage 3, p <0.001) and etiologic agent (viral, p <0.001) were correlated with poor neurologic outcome on discharge. Of the 154 patients that had follow-up, 91 cases were observed to have neurologic deficits (severe, 50; moderate, 29; and mild 12). Twenty patients had improvement of neurologic impairment on subsequent follow-up. Motor deficits (64 cases), cognitive disorders (26 cases) and seizures (17 cases) are the most common neurologic sequela
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