1.Treatment of recurrent cavernous hemangiomas by ethanol thrombosis and pinyangmycin sclerothery
Fengshan GAO ; Jiying DONG ; Jun DU
Chinese Journal of Medical Aesthetics and Cosmetology 2001;0(06):-
Objective To investigate a safe, effective and mini-invasive method in the treatment of recurrent cavernous hemangiomas. Methods Under local or ketamine anesthesia, ethanol was injected into hemangioma to embolize the draining vessels, and 8~16 mg pinyangmycin was then injected into the lesion slowly. After 7~10 days, second injection of pinyangmycin and total 3~5 times were needed as a course of treatment. Results In the 6 cases reported, shrinkage and degradation were observed and finally tumor was disappeared. There was no skin necrosis, no recurrence and other complications in the 1~5 years follow-up period. Conclusion Ethanol embolization and pinyangmycin injection is a safe, simple, mini-invasive, and effective method in treating the recurrent cavernous hemangiomas.
2.Cheiloplasty by incising along the outline for correction of the defection caused by cheiloschisis operation
Jinling LU ; Jiying DONG ; Fengshan GAO
Chinese Journal of Medical Aesthetics and Cosmetology 2002;0(02):-
Objective To find a satisfied repairing method which can complete the functional cheiloplasty while avoiding the visible scar after the cheiloschisis II operation for bilateral cleft lip. Methods The functional operation was carried out in subcutaneous layer by incising along the outline of the nose and the mouth. Results A satisfied effect was achieved after 6 months to 2 years' follow up in 15 cases of the patients (4 cases of bilateral cleft, 11 cases of cheiloschisis). Conclusions The new operation method has improved the traditional method of cheiloplasty. It can effectively repair the secondary defection in nose and mouth resulted from the cheilochisis operation. It can rebuild the orbicularis oris muscle and repair the diseased alar catilage as well. Furthermore, it not only brings a natural looking appearance, but also a natural function and an invisible incision scar. [
3.Relationship between matrix metalloproteinase-9 activity and microemboli formation in patients with cerebral infarction and its clinical significance
Jiying ZHOU ; Guoguang PENG ; Wenwei XIE ; Weiwei DONG ;
Journal of Third Military Medical University 2003;0(09):-
Objective To investigate the relation between plasma matrix metalloproteinase 9 (MMP 9) levels and transcranial Doppler (TCD) detected microemboli in patients with cerebral infarction and evaluate the clinical significance. Methods The plasma MMP 9 levels were quantified by ELISA and the microemboli were detected with TCD in 50 stroke patients and 20 controls. Results The level of plasma MMP 9 was significantly higher in microembolic signal positive patients than that in negative ones [median (392.87?210.90) ng/ml for those with emboli versus (202.27?153.40) ng/ml for those without, P
4.Study on artificial intelligence-based algorithm for acetabular cup in total hip arthroplasty
Dong WU ; Wei CHAI ; Xingyu LIU ; Yicheng AN ; Yiling ZHANG ; Jiying CHEN ; Peifu TANG
Chinese Journal of Orthopaedics 2021;41(3):176-185
Objective:To develop a set of algorithms that could predict the precise size of acetabular cup preoperatively by the deep learning neural network technology.Methods:Retrospective analysis was performed on 30 patients with femoral head necrosis from April 2019 to April 2020, including 15 males and 15 females. At the age of (54.8±10.5) years (range 33-72 years). Thirteen hips on the left and seventeen hips on the right, who underwent primary unilateral THA. Based on the manually segmented hip joint CT database, a deep learning convolutional neural network was trained to realize automatic segmentation. A customized algorithm was created to fit the surface of the acetabulum. By the application of another deep learning convolutional neural network, the identification of anatomical points of the pelvis and correction of the pelvic position were realized. So that the placement of the acetabulum cup could be done. DOC (dice overlap coefficients) as well as the average error parameter were adopted to evaluate the accuracy of the above steps. The novel algorithm and Orthoview software were retrospectively used to template the acetabular cup separately. The results of both groups were compared with the actual size and the coincidence rate was calculated to evaluate the accuracy of the novel algorithm. To verify this algorithm, the conformance rate was calculated respectively.Results:Compared with other classical segmentation networks, the G-NET network can segment the pelvic with femoral head necrosis more accurately (DOC 92.51%± 6.70%). It also has better robustness. The average error of the point recognition network is 0.87 pixels. Among the 30 patients, the AI-based algorithm group had a complete coincidence rate of 96.7% and the Orthoview group had a complete coincidence rate of 73.3%. The difference was statistically significant ( χ2=6.405, P=0.011). Conclusion:The artificial intelligence-based algorithm can segment the CT image series and identify the feature points of the patient's hip accurately. Compared with the conventional 2D preoperative planning method, the AI-based algorithm is relatively more accurate. This artificial intelligence-based 3D preoperative software has promising prospect to makeaccurate surgical plan efficiently.
5.Expressions of hepatocyte nuclear factor -1α and hepatocyte nuclear factor -4α in human hepatocellular carcinoma
Jie ZHENG ; Chengwei DONG ; Jiying JIANG ; Haoyun ZHANG ; Dequan WEI ; Jie DING
Acta Anatomica Sinica 2009;40(6):933-937
Objective To investigate the expression of hepatocyte nuclear factor-1α (HNF-1α) and hepatocyte nuclear factor-4α (HNF-4α) in human hepatocellular carcinoma (HCC) and explore the function of HNF-1α and HNF-4α during HCC carcinogenesis and development. Methods Twenty-six specimens of hepatocellular carcinoma were collected. The expressions of HNF-1α and HNF-4α in HCC tissues and adjacent non-cancerous tissues were detected by reverse transcription polymerase chain reaction (RT-PCR) and immunohistochemistry staining. Results The mRNA levels of HNF-1α and HNF-4α were significantly lower in HCC tissues than that in adjacent non-cancerous tissues (0.818±0.371 vs. 0.383±0.102 for HNF-1α, P<0.05;0.846±0.384 vs. 0.397±0.105 for HNF-4α, P<0.05).The positive rates of HNF-1α and HNF-4α protein were significantly lower in HCC tissues than in adjacent non-cancerous tissues (92.3% vs. 42.3% for HNF-1α, P<0.05;96.2% vs. 50.0% for HNF-4α, P<0.05). The mRNA and protein expressions of HNF-1α and HNF-4α were correlated with tumor differentiation (P<0.05). There was a negative correlation between HNF-1α and HNF-4α mRNA expressions in HCC tissues.Conclusion The expressions of HNF-1α and HNF-4α are down-regulated in HCC, which might be related to carcinogenesis and development of HCC.
6.Study on Morphology of Blastocystis hominis in Culture and from Diarrhea Patients
Xu ZHANG ; Jiying QIAO ; Xiaohui DONG ; Yaqing LI ; Xiaoqi LI ; Chen LI
Chinese Journal of Parasitology and Parasitic Diseases 1987;0(02):-
Objective To study morphology of different stage Blastocystis haminis (B.h) for establishing a base in the research of life cycle and pathogenicity of B. h and providing information for clinical laboratory. Methods B. h from diar-rheal patients was continuously cultured in LES medium, and morphology of B.h was studied with iodine and iron hematoxylin staining under light microscope. Results The vacuolar, granular, amoeboid and cyst forms of B. h and transformation among the forms were observed microscopically. Conclusion Among different forms, the vacuolar and granular forms were often seen clinically and the vacuolar form can transform to cysts.
7. Advances in the research of techniques for traumatic scars intervention with photoelectric acoustic therapy
Chinese Journal of Burns 2018;34(6):418-421
Traumatic scar is a common complication of skin injury, such as burn, trauma, and surgery. The mechanism for scar formation still remains unclear. Traumatic scar has a negative impact on the quality of patients′ life, due to the appearance of scar always causes physical or/and psychological problems to patients. The treatments for scar include surgery, chemotherapy, radiotherapy, and pressure, depending on the kind of scar present. Recently, a great progress in treating scar has been achieved by novel techniques with laser, intense pulsed light, micro-plasma radiofrequency, and ultrasound. The aim of this review is introducing the advances of these techniques for traumatic scars intervention.
8. Clinical effects of a combination treatment with narrow-spectrum intense pulsed light and fractional carbon dioxide laser on hypertrophic scar pruritus
Yiqiu ZHANG ; Jiying DONG ; Shen WANG ; Min YAN ; Min YAO
Chinese Journal of Burns 2018;34(9):608-614
Objective:
To observe the effects of a combination treatment with narrow-spectrum intense pulsed light and fractional carbon dioxide laser on hypertrophic scar pruritus in clinic.
Methods:
A prospective randomized controlled study was conducted. A total of 90 patients with hypertrophic scars conforming to the inclusion criteria who were hospitalized in our ward from March to December 2017 were divided into combination treatment group and control group according to the random number table, with 45 patients in each group. For scar pruritus, patients in control group were treated twice by narrow-spectrum intense pulsed light with a one-month interval, while patients in combination treatment group were firstly treated by narrow-spectrum intense pulsed light combined with fractional carbon dioxide laser once, and with narrow-spectrum intense pulsed light once one month later. Before and 3 months after treatment, scar pruritus was evaluated by the Visual Analogue Scale and the Four-item Itch Questionnaire, and the improvement of scar was assessed by photography. Three months after treatment, the treatment satisfaction of scar pruritus was self-rated by patients. Meanwhile, adverse effects were recorded during the procedures and follow-up periods. Data were processed with Chi-square test, paired
9.Determination of artemisinin in rat plasma with HPLC-mS and its application.
Chuan FU ; Jiying YU ; Jing ZOU ; Lin HE ; Yun DONG ; Yuan HUANG
China Journal of Chinese Materia Medica 2012;37(19):2964-2967
OBJECTIVETo develop a method for determining artemisinin in rat plasma in vivo.
METHODHPLC-MS was adopted. Estazolam was selected as an internal standard (I.S.). The sample and I.S. were extracted using methyl tertbutyl ether and measured at m/z of 305 and 296, respectively.
RESULTWithin the linear range of 5-500 microg x L(-1), the ratio of artemisinin's peak area and I.S. peak area and the concentration showed good linearity, thus the minimum concentration was set to be 5 mictrog x L(-1).
CONCLUSIONThe methodology proved that the method is so suitable for determining the drug concentration in rat blood that it can be used for studying pharmacokinetics in animals.
Animals ; Artemisinins ; pharmacokinetics ; Chromatography, High Pressure Liquid ; Mass Spectrometry ; Rats
10. Study of iron overload assessment by T2* magnetic resonance imaging in patients with myelodysplastic syndromes
Luxi SONG ; Hongyu LU ; Chao XIAO ; Lingyun WU ; Dong WU ; Jiying SU ; Liyu ZHOU ; Chunkang CHANG
Chinese Journal of Hematology 2019;40(3):222-226
Objectives:
To analyze the cardiac T2* value, liver iron concentration (LIC) , and related laboratory parameters in myelodysplastic syndrome (MDS) with iron overload and evaluate the changes of organ functions after iron chelation therapy. To explore the value of magnetic resonance imaging (MRI) T2* in making early diagnosis and assessing organs iron overload.
Methods:
Retrospective investigation was used to observe the cardiac T2* value, LIC, iron metabolism parameters and related laboratory parameters of 85 MDS patients from Nov 2014 to Jan 2018. Among them, 7 MDS patients with Low/Int-1 have received iron chelation therapy for 6 months during two MRI examinations. The above parameters were collected before and after iron chelation therapy for comparison.
Results:
Correlations were found between heart T2* value and age (